Decreased circulating CD34+ cells are associated with progression of diabetic nephropathy

Abstract

These results suggest that a decreased number of circulating CD34+ cells is involved in the progression of diabetic nephropathy and may be a predictor of the disease.

Specific Role of Impaired Glucose Metabolism and Diabetes Mellitus in Endothelial Progenitor Cell Characteristics and Function

“…22 Moreover, decreased secretion of NO and vascular endothelial growth factor (VEGF), reduced activity of superoxide dismutase, and impaired function, such as migration and tube formation, are observed in activated late EPCs after exposure to a hyperglycemic condition 23 or advanced glycation end products. 24 Reduced number and function of EPCs are also more prevalent in patients with type 1 and type 2 DM with diabetic nephropathy [25][26][27][28] and macrovascular 26,[29][30][31][32][33] complications and correlate with the degree of atherosclerosis. 34 These observations suggest that the burden of DM-related cardiovascular complications correlates with the number and function of EPCs: alterations in EPCs may contribute to the development and progression of atherosclerosis in patients with DM.…”

“…28,35,59,72 Glucagon-like peptide-1 agonist and DPP-4 inhibitors are a newer class of antidiabetic agents that act by increasing the Figure 2. Potential therapeutic avenues to restore endothelial progenitor cell (EPC) number and functions for the prevention of macrovascular and microvascular complications in diabetes mellitus (DM).…”

Endothelial progenitor cells in diabetes complications

“…У пациентов с большим количеством CD34+ клеток экскреция альбумина не изме-нилась в течение 12 мес. Исследователи пришли к выводу, что циркулирующие CD34+ клетки участвуют в прогрес-сировании ДН, и данный показатель можно использовать в качестве прогностического маркера ДН [35]. В другом исследовании также показано, что количество циркулиру-ющих CD34+ и CD34+CD133+ клеток ниже у пациентов с МАУ по сравнению с пациентами без МАУ.…”

“…Снижение количества клеток коррелирует с наличием МАУ [28] и прогнозирует прогрессирование МАУ [35]. Снижение количества клеток и нарушение их функции коррелируют с наличием МАУ [28].…”

Endothelial Progenitor Cells Dysfunction in Diabetes Mellitus

“…Interestingly, at the early stage of metabolically inactive obesity ("not fully" metabolic syndrome) BM-EPCs number may increase and an ability of primitive cells to mobbing, differentiation and colony forming might be not distinguished healthy individuals [66]. In contrast, development of insulin resistance, metabolic syndrome and type 2 DM has closely associated with weak ability of EPCs to mobbing, and the lowered level of circulating EPCs was determined [67]. In contrast, Asnaghi V et al (2006) [68] have reported that clonogenic potential of circulating EPCs in patients with type 1 DM may increase.…”