Decreased collagen type�I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses

Junge, K.; Klinge, U.; Rösch, R.; Mertens, Peter R.; Kirch, J.A.J.M.; Klosterhalfen, B.; Lynen, Petra; Schumpelick, Volker

doi:10.1007/s00423-003-0429-8

Cited by 157 publications

(39 citation statements)

References 26 publications

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“…27 Multiple studies have shown decreased collagen I/III ratios in mature skin scars from patients with either primary or recurrent incisional hernias compared with mature abdominal skin scars from patients without hernias 23, 28–31 and in periprosthetic scar of recurrent inguinal and incisional hernias. 32 A common link between all hernias has been found by some studies including differing etiologies. Ozdemir et al 33 included indirect, direct, and incisional hernias in their evaluation of copper and zinc levels.…”

Section: Evidence For Collagenopathies In Herniasmentioning

confidence: 94%

Collagenopathies—Implications for Abdominal Wall Reconstruction: A Systematic Review

Harrison

Sanniec

Janis

2016

Plastic and Reconstructive Surgery - Global Open

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Background:The etiology of hernia formation is strongly debated and includes mechanical strain, prior surgical intervention, abnormal embryologic development, and increased intraabdominal pressure. Although the most common inciting cause in ventral hernias is previous abdominal surgery, many other factors contribute. We explore this etiology through an examination of the current literature and existing evidence on patients with collagen vascular diseases, such as Ehlers–Danlos syndrome.Methods:A systematic review of the published literature was performed of all available Spanish and English language PubMed and Cochrane articles containing the key words “collagenopathies,” “collagenopathy,” “Ehlers-Danlos,” “ventral hernia,” and “hernia.”Results:Three hundred fifty-two articles were identified in the preliminary search. After review, 61 articles were included in the final review.Conclusions:Multiple authors suggest a qualitative or quantitative defect in collagen formation as a common factor in hernia formation. High-level clinical data clearly linking collagenopathies and hernia formation are lacking. However, a trend in pathologic studies suggests a link between abnormal collagen production and/or processing that is likely associated with hernia development.

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Section: Evidence For Collagenopathies In Herniasmentioning

confidence: 94%

Collagenopathies—Implications for Abdominal Wall Reconstruction: A Systematic Review

Harrison

Sanniec

Janis

2016

Plastic and Reconstructive Surgery - Global Open

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“…Though a high amount of collagen type III is related to inflammation and the early phase of wound healing, a similar pattern is also seen in patients with disturbed wound-healing process [25] or in the scar of chronic foreign body reaction around meshes [25,26].…”

Section: Discussionmentioning

confidence: 93%

Absence of circulating aldosterone attenuates foreign body reaction around surgical sutures

Klinge

Theuer

Krott

et al. 2009

Langenbecks Arch Surg

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“…However, the mesh-induced inflammatory reaction frequently causes complications, including seroma formation, mesh shrinkage and migration, adhesion, infection, and pain. [26]…”

Section: Discussionmentioning

confidence: 99%

Polyglactine/Polypropylene Mesh vs. Propylene Mesh: Is there a need for newer prosthesis in inguinal hernia?

Khan

Bangash

Sadiq

et al. 2010

Saudi J Gastroenterol

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Background/Aim:To compare outcomes of light and heavy weight mesh for repair of inguinal hernia.Materials and Methods:This study was conducted at the Department of Surgery; Lady Reading Hospital, Peshawar from January 1, 2007 to December 31, 2008. Patients were divided into two groups based on the type of mesh implanted for inguinal hernia repair. Group 1 included patients in whom light weight composite (VyproII®) mesh is implanted: Group 2 included patients in whom polypropylene (ProleneR) mesh is implanted. Data concerning the complications and post operative pain in the perioperative and postoperative period were collected and analyzed. Categorical data were presented as percentages with 95% confidence intervals and compared using a χ2test and P<0.05 were considered significant.Results:Following allocation and exclusion of violating cases, 111 patients in group 1 and 138 patients in group 2 were analyzed. The mean age in group 1 was 38.20 ± 13.34 years and in group 2 was 39.55 ± 13.70 (P = 0.434). In group 1, hematoma formation was observed in four cases (3.6%), while it was observed in six cases (4.2%) in group 2 (P = 0.766). During the entire study, ten patients in all developed urinary retention, three of which required transient catheterization. One year post operation, there was a recurrence in only five cases overall, while only two patients complained of pain (P = 0.826).Conclusion:The frequency of postoperative pain and complications in patients was similar in both groups.

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Decreased collagen type�I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses

Cited by 157 publications

References 26 publications

Collagenopathies—Implications for Abdominal Wall Reconstruction: A Systematic Review

Collagenopathies—Implications for Abdominal Wall Reconstruction: A Systematic Review

Absence of circulating aldosterone attenuates foreign body reaction around surgical sutures

Polyglactine/Polypropylene Mesh vs. Propylene Mesh: Is there a need for newer prosthesis in inguinal hernia?

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