Decreased colonic motility in persons with chronic spinal cord injury

Fajardo, Noel R.; Pasiliao, Ronnie-Vic; Modeste-Duncan, Roberta; Creasey, Graham; Bauman, William A.; Korsten, Mark A.

doi:10.1111/j.1572-0241.2003.07157.x

Cited by 63 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 It is known that decreased sacral parasympathetic innervations and colonic motility can result in prolonged CTT. 9 Our data support previous findings (using less advanced technology) and demonstrate that CTT is delayed in both paraplegic and tetraplegic patients, with no significant difference between the two subgroups. 10,11 The colon is largely responsible for absorption of water from digestive waste, and prolonged colonic transit may result in hardened stool and subsequent constipation or impaction.…”

Section: Discussionsupporting

confidence: 91%

SmartPill technology provides safe and effective assessment of gastrointestinal function in persons with spinal cord injury

et al. 2011

View full text Add to dashboard Cite

Study design: Spinal cord injury (SCI) results in gastrointestinal (GI) complications, including gastroesophageal reflux disease and constipation, but much of the data is based on older technology. Objective: GI transit times were determined in subjects with SCI using a new device called a SmartPill. Our principal goal was to assess whether this new technology can be applied in persons with SCI. Methods: SCI and age-and gender-matched able-bodied (AB) control subjects not taking proton pump inhibitors were studied. Following an 8-h overnight fast, subjects consumed 120 g EggBeaters (60 kcal), two slices of white bread (120 kcal) and 30 g strawberry jam (74 kcal). A pH calibrated SmartPill capsule was swallowed with 8 ounces of water, after which subjects fasted for an additional 6 h prior to consuming an Ensure Plus nutrition shake (350 kcal). Subjects remained fasted for an additional 2 h, after which time they resumed their regular diets. Results: Twenty subjects with SCI and 10 AB control subjects were studied. Data are expressed as mean±s.d. Comparing the group with SCI to the AB control group, gastric emptying time (GET), colonic transit time (CTT) and whole gut transit time (WGTT) were prolonged (GET: 10.6 ± 7.2 vs 3.5 ± 1.0 h, Po0.01; CTT: 52.3 ± 42.9 vs 14.2 ± 7.6 h, P¼0.01; WGTT: 3.3 ± 2.5 vs 1.0 ± 0.7 days, Po0.01). No complications or side effects were reported. Conclusion: Our results indicate that the SmartPill technology is a safe, non-invasive assessment technique that provides valid diagnostic information in persons with SCI.

show abstract

Section: Discussionsupporting

confidence: 91%

SmartPill technology provides safe and effective assessment of gastrointestinal function in persons with spinal cord injury

et al. 2011

View full text Add to dashboard Cite

show abstract

“…13 A previous study found that patients with higher tetraplegia had the highest prevalence of bowel problems compared with patients with lower paraplegia. 14 Lynch et al 15 also reported that the level of the spinal cord lesion determines the effect on colonic motility, and cervical injuries can result in more remarkable constipation, abdominal distention and discomfort.…”

Section: Discussionmentioning

confidence: 96%

Prediction of severe neurogenic bowel dysfunction in persons with spinal cord injury

Liu

Huang

et al. 2010

Spinal Cord

View full text Add to dashboard Cite

Study design: Cross-sectional study. Objective: To analyze the predictors of severe neurogenic bowel dysfunction (NBD) in persons with spinal cord injury (SCI). Setting: The Kaohsiung Medical University Hospital, Taiwan. Methods: Two questionnairesFthe NBD score and the Beck Depression Inventory second editionFwere sent to 232 persons with SCI by mail. The demographic factors and injury-related factors were recorded to evaluate any relationships with severe NBD. The associations between the severity of NBD and psychological condition were also measured. Results: In all, 39.4% of the respondents suffered from severe NBD. Multiple logistic regression analysis showed that those with a cervical injury (odds ratios (OR) ¼ 10.5, 95% confidence interval (CI) 1.6-67.7) or a thoracic injury (OR ¼ 7.1, 95% CI 1.2-40.3) had a higher risk of severe NBD than those with a lumbar injury. Persons with American Spinal Injury Association (ASIA) A had a 12.8-fold higher risk of severe NBD than persons with ASIA D (OR ¼ 12.8, 95% CI 3.3-50.1). Longer duration of injury (X10 years) was another risk factor of severe NBD. Moderate-to-severe depression was associated with reduced bowel function. Conclusions: This study showed that high level of cord lesion, completeness of cord injury and longer duration of injury (X10 years) could predict the severity of NBD in patients with SCI.

show abstract

“…Neurogenic bowel (defined as colonic dysfunction from lack of nervous control) following a traumatic spinal cord injury (SCI) has been well studied [1][2]. In upper motor neuron type SCI lesions above the conus medullaris, supra-spinal inhibitory input is lost, hence reduced colonic motility and increased difficulty in rectal emptying [3][4].…”

Section: Introductionmentioning

confidence: 99%

Colonoscopic lesions in veterans with spinal cord injury

Rabadi¹,

Vincent²

2012

JRRD

View full text Add to dashboard Cite

Abstract-The overall goal of this observational study was to determine the type and prevalence of colonoscopic lesions encountered in veterans with traumatic spinal cord injury (SCI) and to examine their relationship to lesion level, completeness, and duration postinjury. We retrospectively reviewed the electronic charts of veterans with SCI who are regularly followed in our SCI clinic. Colonoscopy in veterans with SCI was undertaken for their gastrointestinal (GI) complaints. Of the 87 veterans with SCI, 71 who were 50 years of age or older were included in this study. Of these 71, 28 underwent colonoscopies (39.4%). Demographic variables were matched between patients who underwent colonoscopies and those who did not for age, sex, race/ethnicity, age of onset of SCI, and duration of SCI (p > 0.05). The colonoscopic lesions seen in 26 (93%) of the 28 veterans with SCI who underwent colonoscopies included diverticulae, internal hemorrhoids, and polyps. No relationship was found between colonoscopic lesion type and SCI lesion location or severity. A relationship was found between total colonoscopic lesions and duration of SCI (p < 0.001). Age-, sex-, and race/ethnicitymatched veterans without SCI (controls) who underwent colonoscopy for their GI complaints had more colonoscopic lesions than the veterans with SCI who underwent colonoscopies (p < 0.001).

show abstract

Decreased colonic motility in persons with chronic spinal cord injury

Abstract: SCI decreases colonic motility, and this alteration may relate to difficulty with evacuation. The postprandial colonic response in SCI is present but is suboptimal and confined to the descending colon.

Cited by 63 publications

References 13 publications

SmartPill technology provides safe and effective assessment of gastrointestinal function in persons with spinal cord injury

SmartPill technology provides safe and effective assessment of gastrointestinal function in persons with spinal cord injury

Prediction of severe neurogenic bowel dysfunction in persons with spinal cord injury

Colonoscopic lesions in veterans with spinal cord injury

Contact Info

Product

Resources

About