Decreased contractile effect of endothelin-1 on hyperplastic prostate

Area Density of Smooth Muscle Cells and Response to Endothelin 1 in Human Hyperplastic Prostate

“…As reported in previous papers [12, 25, 26], in the present series ET–1 induced dose–dependent contractile responses in the strips obtained from human hyperplastic prostate. ET–1 induces contractile responses in the strips obtained from the human prostate by an α–receptor–independent mechanism, since the concentration response to ET–1 is not influenced by pretreatment with an α–blocker [13].…”

“…Moreover, ET–1 and its receptors are primarily localized in glandular epithelium in BPH tissue. Thus, the authors concluded that ET–1 might not have an important role in the occurrence of the obstructive symptoms of BPH [26]. However, in the present study, ET–1 demonstrated contraction of the PBH tissue that was equal to PE–induced contraction.…”

“…The magnitudes of ET–1–induced contraction in the nonhyperplastic prostate are almost the same as those induced by PE [13]. However, according to Moriyama et al [26], the responsiveness to ET–1 decreased in tissue from BPH patients, compared to those from normal prostate. On the contrary, the response to PE is not different between normal and hyperplastic prostates [26].…”

“…However, according to Moriyama et al [26], the responsiveness to ET–1 decreased in tissue from BPH patients, compared to those from normal prostate. On the contrary, the response to PE is not different between normal and hyperplastic prostates [26]. Moreover, ET–1 and its receptors are primarily localized in glandular epithelium in BPH tissue.…”

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model

“…Endothelin-1 is elevated in PIN lesions and in the plasma of men with prostate cancer (36,37). The finding that angiogenin is likewise elevated in the plasma of prostate cancer patients suggests that the MPAKT model recapitulates a number of elements commonly seen in human disease.…”