Decreased dehydroepiandrosterone sulphate levels in adolescents with post-traumatic stress disorder after single sexual trauma

Usta, Miraç Barış; Tunçel, Özgür Korhan; Akbaş, Seher; Aydın, Berna; Say, Gökçe Nur

doi:10.3109/08039488.2015.1056752

Cited by 20 publications

(18 citation statements)

References 33 publications

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“…These studies investigated CM in PTSD patients with mixed results: whereas one study observed an association of CM with elevated concentrations of DHEA in blood plasma of PTSD patients [24], another study investigating a sample of adult smokers with and without PTSD did not find a significant effect of CM on DHEA concentrations in blood serum [18]. In the aftermath of sexual trauma, PTSD patients showed significantly reduced DHEA levels compared to age-matched controls in two studies measuring steroids in saliva [25] and blood [26]. As all reported studies investigated DHEA in blood, the assessment of DHEA in hair as a cumulative measure over time might clarify the existing inconsistent findings.…”

Section: Introductionmentioning

confidence: 99%

Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

et al. 2017

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BackgroundChild maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important signaling molecules, cortisol and DHEA in hair, shortly after parturition. In addition, we explored potential effects of maternal CM on her offspring’s endocrine milieu during pregnancy by measuring cortisol and DHEA in newborns’ hair.MethodsCM was assessed with the Childhood Trauma Questionnaire (CTQ). Cortisol and DHEA were measured in hair samples of 94 mothers and 30 newborns, collected within six days after delivery. Associations of maternal CM on her own and her newborn’s cortisol as well as DHEA concentrations in hair were analyzed with heteroscedastic regression models.ResultsHigher CM was associated with significantly higher DHEA levels, but not cortisol concentrations in maternal hair. Moreover, maternal CM was positively, but only as a non-significant trend, associated with higher DHEA levels in the newborns’ hair.ConclusionsResults suggest that the steroid milieu of the mother, at least on the level of DHEA, is altered after CM, possibly leading to non-genomic transgenerational effects on the developing fetus in utero. Indeed, we observed on an explorative level first hints that the endocrine milieu for the developing child might be altered in CM mothers. These results need extension and replication in future studies. The measurement of hair steroids in mothers and their newborns is promising, but more research is needed to better understand the effects of a maternal history of CM on the developing fetus.Electronic supplementary materialThe online version of this article (doi:10.1186/s12888-017-1367-2) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

et al. 2017

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“…Interestingly, and relevant to the current discussion, the authors concluded that DHEA failed as trauma indicator, as it was found to be significantly influenced by personality. In terms of adolescent PTSD, both acute (single event rape) and chronic (repeated sexual abuse) trauma was reported to be associated with decreased DHEA concentrations [58,59]. Current data similarly indicates DHEAs levels below the expected normal range for the majority of study participants with high anxiety proneness in the absence of trauma exposure.…”

Section: Discussionmentioning

confidence: 61%

Anxiety: An overlooked confounder in the characterisation of chronic stress-related conditions?

et al. 2020

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Although anxiety disorders are among the most prevalent of psychiatric disorders, childhood trauma-related studies seldom consider anxiety proneness as distinct aetiological contributor. We aimed to distinguish between trauma-and anxiety-associated physiological profiles. South African adolescent volunteers were categorised for trauma exposure (CTQ, mean score 39±11) and anxiety proneness (AP)(CASI, mean score 37±7, STAI-T, mean score 41 ±8). Circulating hormone and leukocyte glucocorticoid receptor levels, as well as leukocyte functional capacity, were assessed. AP was associated with lower DHEAs (P<0.05) and higher leukocyte GR expression (P<0.05). DHEAs was also negatively correlated with anxiety sensitivity (CASI, P<0.05). In conclusion, AP may have more predictive power than trauma in terms of health profile. Increased glucocorticoid sensitivity previously reported after trauma, may be a unique function of anxiety and not trauma exposure per se. DHEAs concentration was identified as potentially useful marker for monitoring progressive changes in HPA-axis sensitivity and correlated with psychological measures of anxiety.

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“…[5] DHEA-S could not differentiate between primary or secondary adrenal failure and low DHEA-S also found after post-traumatic stress disorder and depressive symptoms. [21] The worst performance was plasma ACTH in this study. This result proved before, where it is useful in the diagnosis of primary AI.…”

Section: Discussionmentioning

confidence: 99%

“…[5] The potential application of this study is that DHEA-S used as a tool to diagnose hypothalamic pituitary adrenal dysfunction in the afternoon because DHEA-S not subjected to circadian rhythm due to prolonged half-life. [11,20,21,[26][27][28] Since the majority of HPAD will present at afternoon to the emergency units or hospitals were the short cosyntropin not feasible and serum cortisol, and plasma ACTH will become unreliable.…”

Section: Discussionmentioning

confidence: 99%

The performance of serum cortisol, plasma corticotropin and serum dehydroepiandrosterone sulfate levels in the diagnosis of hypothalamic pituitary adrenal dysfunction

Alhamza¹,

Mansour²,

Haddad³

2015

Int Arch Med

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Background: There is no single test can identify hypothalamic-pituitary-adrenal dysfunction (HPAD) perfectly. The study aimed to assess the performance of measuring serum cortisol, serum dehydroepiandrosterone sulfate (DHEA-S) and plasma corticotropin (ACTH) in comparison with standard-dose short cosyntropin (250 µg) testing for the diagnosis of HPAD.Methods: This is a cross-sectional study from Al-Faiha Specialized Diabetes, Endocrine, and Metabolism Center (FDEMC) in Basrah for the period of November 2014 to October 2015. For all patients with suspected HPAD; baseline serum cortisol, serum DHEA-S and plasma ACTH and were measured, followed by a formal short cosyntropin test as the gold standard test. Results:The total number of the study participant was 169 patients.Of them, 134 (79.3%) were women. Their age ranges from 5-80 years. The cut-off serum cortisol that predicts abnormal short cosyntropin test was less than 5.31 µg/dl with maximal sensitivity and specificity of 87.7% and 90.4% respectively. The cut-off serum DHEA-S that predict abnormal short cosyntropin test was less than 31.11 µg/dl with a sensitivity of 89.2%and specificity of 62.7%. The least reliable parameter to predict the abnormal short cosyntropin was the plasma ACTH level with a cut-off of less than 5.30 pg/ml and lowest sensitivity of 68.8% and specificity of 74.5%. Conclusion:To exclude HPAD, serum cortisol at 9-11 am having the highest predictive value, DHEA-S has the midway function and plasma

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Decreased dehydroepiandrosterone sulphate levels in adolescents with post-traumatic stress disorder after single sexual trauma

Abstract: Decreased DHEA-S levels and correlation with depressive symptoms are evidence for a dysregulated HPA-axis in female adolescent single sexual trauma victims with PTSD. Further research is now recommended with large patient groups in order to maximize generalizations.

Cited by 20 publications

References 33 publications

Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

Anxiety: An overlooked confounder in the characterisation of chronic stress-related conditions?

The performance of serum cortisol, plasma corticotropin and serum dehydroepiandrosterone sulfate levels in the diagnosis of hypothalamic pituitary adrenal dysfunction

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