Decreased dopaminergic tone and increased basal bioactive prolactin in men with human immunodeficiency virus infection

Parra, Adalberto; Ramírez-Peredo, Jorge; Larrea, Fernando; Cabrera, Víctor; Coutiño, Blanca; Angeles, Angélica; Pérez‐Romano, Beatriz; Ruíz‐Argüelles, Guillermo J.; Ruı́z-Argüelles, Alejandro

doi:10.1046/j.1365-2265.2001.01262.x

Cited by 18 publications

(17 citation statements)

References 34 publications

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“…[17] Current postualtion is that HIV infection reduces dopaminergic tone and thereby increases the bioactivity of prolactin, though the machanism of this effect remains unclear. [18]…”

Section: Functional Derangement Of Endocrine Organs: Direct Effect Ofmentioning

confidence: 99%

Human immunodeficiency virus endocrinopathy

Sinha

Sengupta

Mukhopadhyay

et al. 2011

Indian J Endocr Metab

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Human immunodeficiency virus (HIV) endocrinopathy encompasses a broad spectrum of disorders. Almost all the endocrine organs are virtually affected by HIV infection. HIV can directly alter glandular function. More commonly secondary endocrine dysfunction occurs due to opportunistic infections and neoplasms in immunocompromised state. The complex interaction between HIV infection and endocrine system may be manifested as subtle biochemical and hormonal perturbation to overt glandular failure. Antiretroviral therapy as well as other essential medications often result in adverse endocrinal consequences. Apart from adrenal insufficiency, hypogonadism, diabetes and bone loss, AIDS wasting syndrome and HIV lipodystrophy need special reference. Endocrinal evaluation should proceed as in other patients with suspected endocrine dysfunction. Available treatment options have been shown to improve quality of life and long-term mortality in AIDS patients.

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“…[17] Current postualtion is that HIV infection reduces dopaminergic tone and thereby increases the bioactivity of prolactin, though the machanism of this effect remains unclear. [18]…”

Section: Functional Derangement Of Endocrine Organs: Direct Effect Ofmentioning

confidence: 99%

Human immunodeficiency virus endocrinopathy

Sinha

Sengupta

Mukhopadhyay

et al. 2011

Indian J Endocr Metab

View full text Add to dashboard Cite

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“…Além disso, a hiperprolactinemia pode estar associada ao surgimento de hipogonadismo central (37). Evidên-cias sugerem aumento da bioatividade da prolactina em pacientes infectados pelo HIV por redução do tônus dopaminérgico nesses pacientes (38). Hiperprolactinemia associada à galactorreia tem ainda sido relatada em usuários de inibidores de protease.…”

Section: Ginecomastia E Hiperprolactinemiaunclassified

Disfunção do eixo gonadotrófico em homens com infecção pelo HIV/Aids

Ponte

Gurgel

Montenegro

2009

Arq Bras Endocrinol Metab

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RESUMOA disfunção do eixo gonadotrófico é frequentemente observada em pacientes infectados pelo HIV. A patogênese é multifatorial e está relacionada à duração da infecção pelo HIV, aos efeitos citopáticos diretos do vírus, ao uso de drogas gonadotóxicas, às infecções oportunistas, às neo plasias, à desnutrição, entre outros fatores. Em homens, a redução dos níveis de testosterona está associada à perda de massa e de força muscular, à redução da densidade mineral óssea, à lipodistrofia, à depressão, à astenia, à fadiga e à disfunção sexual. Em pacientes infectados pelo HIV com hipogonadismo, inúmeros estudos têm comprovado os efeitos benéficos da reposição de testosterona sobre o perfil metabólico e a distribuição da gordura corporal, com aumento da massa corporal magra, além de promover melhora da qualidade de vida, reduzir a perda de mas sa óssea e reduzir os índices de depressão. Assim, esta revisão teve como objetivo trazer uma breve atualização sobre o presente tema, abordando dados epidemiológicos, mecanismos fisio patológicos e estratégias terapêuticas para as principais anormalidades do eixo gonadotrófico masculino associadas à infecção pelo HIV e ao seu tratamento. ABSTRACTGonadotrophic axis dysfunction is commonly observed in HIVinfected patients. The pathogen esis is multifactorial and related to duration of HIV infection, direct cytopathic effects of viruses, use of drugs, opportunistic infections, malignancies, and malnutrition, among other factors. In men, reduced levels of testosterone is associated with loss of muscle mass and strength, de creased bone mineral density, lipodystrophy, depression, asthenia, fatigue and sexual dysfunc tion. In HIVinfected patients with hypogonadism, numerous studies have shown the beneficial effects of testosterone replacement on the metabolic profile and distribution of body fat, with increased body mass weight, and promote better quality of life, reduce the bone mass loss and the rates of depression. Thus, this review aimed to present a brief update of epidemiologic data, pathophysiology aspects and treatment strategies for the major abnormalities of male gonado trophic axis associated with HIV infection and its treatment. Arq Bras Endocrinol Metab. 2009;53(8):983-8

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“…The diagnosis of HIV infection was confirmed by immunoblot analysis for HIV antibodies, and T cells expressing the CD4 and CD8 molecules were determined by three‐colour flow cytometry using fluorescent specific monoclonal antibodies 29 . Detailed clinical characteristics of the volunteers have been previously published 24 …”

Section: Methodsmentioning

confidence: 99%

“…Despite the overwhelming information regarding the possible role of PRL, especially biologically active PRL, in HIV infection, this area has remained largely unexplored. Nevertheless, some studies have suggested indirectly that the existence of a low DA tone in men with HIV‐infection 21 , 22 , 23 , 24 could represent an adaptive mechanism attempting to stimulate human lymphocyte proliferation at a maximum possible rate in an attempt to survive 25 . The aim of the present study was to explore the in vivo and in vitro production of bioactive PRL in a group of untreated HIV‐infected men and its association with the cell cycle and apoptosis of PBMC in these patients.…”

Section: Introductionmentioning

confidence: 99%

Serum prolactin is associated with apoptosis in men with human immunodeficiency virus infection

et al. 2001

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SummaryWe examined the in vivo and in vitro production of prolactin (PRL) in 20 untreated HIV-infected men compared to 14 uninfected men and its association with the cell cycle and apoptosis. Compared to uninfected men, the HIV-infected men had: (i) higher fasting serum bioactive (BIO) PRL; (ii) lower serum immunoreactive (RIA) and BIO-PRL responses to intravenous metoclopramide; (iii) greater BIO-RIA PRL ratio both fasting and during intravenous metoclopramide; (iv) lower percentage of non-stimulated PBMC in the G 0 /G 1 phase, but a higher percentage in the S phase, of the cell cycle with normal response to Concanavalin-A; and (v) higher in vitro production of BIO-PRL by non-stimulated PBMC, which was blocked after Concanavalin-A. Fasting serum BIO-PRL positively correlated with the percent of non-stimulated PBMC in S + G 2 /M phases. The percentage of apoptotic PBMC negatively correlated with CD4 + T lymphocytes and with the area under the serum RIA-PRL curve, but positively correlated with the area under the curve for the BIO/RIA ratio. These results suggest that in these HIV-infected men: (i) a diminished dopaminergic tone may exist, as an adaptive mechanism attempting to survive; and (ii) BIO-PRL may participate as a cofactor in the stimulation of T-cell proliferation.

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Decreased dopaminergic tone and increased basal bioactive prolactin in men with human immunodeficiency virus infection

Cited by 18 publications

References 34 publications

Human immunodeficiency virus endocrinopathy

Human immunodeficiency virus endocrinopathy

Disfunção do eixo gonadotrófico em homens com infecção pelo HIV/Aids

Serum prolactin is associated with apoptosis in men with human immunodeficiency virus infection

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