Decreased dysmenorrhea pain in girls by reducing oxidative stress and inflammatory biomarkers following supplementation with oleoylethanolamide: A randomized controlled trial

Kazemi, Mahnaz; Lalooha, Fatemeh; Nooshabadi, Mohammadreza Rashidi; Haghighian, Hossein Khadem

doi:10.1111/jog.15196

Cited by 7 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its metabolic potential explains its significance in host health and disease ( 36 , 37 ). Studies have found that the occurrence and development of PD are related to the decrease of human immunity, the increase of inflammatory factors, the abnormal secretion of hormones and other factors, but there are relatively few studies on whether it is related to flora ( 38 , 39 ). The results of this study showed that GWUAP could affect the OTU composition of intestinal flora in PD rats, regulate the diversity of flora, and screen out multiple differential flora related to treatment.…”

Section: Discussionmentioning

confidence: 99%

To explore the mechanism of acupoint application in the treatment of primary dysmenorrhea by 16S rDNA sequencing and metabolomics

Wang,

Li,

Cao

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

Graphene-based warm uterus acupoint paste (GWUAP) is an emerging non-drug alternative therapy for the treatment of primary dysmenorrhea (PD), but the underlying mechanism is still unclear. SD female rats were randomly divided into control group, model group and treatment group to explore the mechanism of GWUAP in the treatment of PD. Combined with 16S rDNA and fecal metabolomics, the diversity of microbiota and metabolites in each group was comprehensively evaluated. In this study, GWUAP reduced the torsion score of PD model rats, improved the pathological morphology of uterine tissue, reduced the pathological damage score of uterine tissue, and reversed the expression levels of inflammatory factors, pain factors and sex hormones. The 16 S rDNA sequencing of fecal samples showed that the abundance of Lactobacillus in the intestinal flora of the model group decreased and the abundance of Romboutsia increased, while the abundance of Lactobacillus in the intestinal flora of the treatment group increased and the abundance of Romboutsia decreased, which improved the imbalance of flora diversity in PD rats. In addition, 32 metabolites related to therapeutic effects were identified by metabolomics of fecal samples. Moreover, there is a close correlation between fecal microbiota and metabolites. Therefore, the mechanism of GWUAP in the treatment of PD remains to be further studied.

show abstract

Section: Discussionmentioning

confidence: 99%

To explore the mechanism of acupoint application in the treatment of primary dysmenorrhea by 16S rDNA sequencing and metabolomics

Wang,

Li,

Cao

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…The intensity of pain during menstruation can be caused by dysmenorrhea which has different levels of pain in each student according to what students feel during menstruation. The psychological impact of dysmenorrhea can be in the form of emotional conflicts, tension, and anxiety (Kazemi, Lalooha, Nooshabadi, & Haghighian, 2022). This can lead to feelings of discomfort and alienation.…”

Section: Discussionmentioning

confidence: 99%

The Relationship of the Dysmenorrhea a in Students with Learning Activities

Halitopo

2022

midwifery

View full text Add to dashboard Cite

Dysmenorrhea is one of the genetic complaints experienced by almost all women but with different levels of pain and different pain responses, so that it has an impact on daily activities such as social, study, work and daily activities. Learning activities are a process of teaching and learning activities that can be in the form of listening, asking questions, discussing, and writing. This study aims to determine the relationship between learning activities and the incidence of dysmenorrhea. The research method used is descriptive analytic research with cross sectional design. The research sample was 89 students of SMA Muhammadiyah Jayapura with a sampling technique using simple random sampling. Data were collected from respondents using questionnaires. The resultd showed that 85.5% of students who experienced moderate pain and 77.9% of students who experienced severe pain stated that they did not concentrate when doing learning activities. The results of the chi square test showed p value = 0.001, which means that there is a relationship between the incidence of dysmenorrhea and student learning activities. Dysmenorrhea can affect learning activities, this is supported by the duration of bleeding, pain during dysmenorrhea, and the intensity of dysmenorrhea.

show abstract

“…Furthermore, OEA treatment improves the glycemic index and insulin resistance, and it may be a helpful supplement to control pre-diabetes status [ 102 ]. Moreover, OEA use has been indicated to alleviate dysmenorrhea pain in girls by reducing oxidative stress and inflammatory biomarkers [ 103 ]. Interestingly, OEA therapy influences gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches [ 104 ].…”

Section: Oleoylethanolamidementioning

confidence: 99%

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

et al. 2023

View full text Add to dashboard Cite

In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high nutraceutical value. The positive effects of olive oil have often been attributed to its minor components; however, its oleic acid (OA) content (70–80%) is responsible for its many health properties. OA is an effective biomolecule, although the mechanism by which OA mediates beneficial physiological effects is not fully understood. OA influences cell membrane fluidity, receptors, intracellular signaling pathways, and gene expression. OA may directly regulate both the synthesis and activities of antioxidant enzymes. The anti-inflammatory effect may be related to the inhibition of proinflammatory cytokines and the activation of anti-inflammatory ones. The best-characterized mechanism highlights OA as a natural activator of sirtuin 1 (SIRT1). Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. OEA regulates dietary fat intake and energy homeostasis and has therefore been suggested to be a potential therapeutic agent for the treatment of obesity. OEA has anti-inflammatory and antioxidant effects. The beneficial effects of olive oil may be related to the actions of OEA. New evidence suggests that oleic acid may influence epigenetic mechanisms, opening a new avenue in the exploration of therapies based on these mechanisms. OA can exert beneficial anti-inflammatory effects by regulating microRNA expression. In this review, we examine the cellular reactions and intracellular processes triggered by OA in T cells, macrophages, and neutrophils in order to better understand the immune modulation exerted by OA.

show abstract

Decreased dysmenorrhea pain in girls by reducing oxidative stress and inflammatory biomarkers following supplementation with oleoylethanolamide: A randomized controlled trial

Cited by 7 publications

References 27 publications

To explore the mechanism of acupoint application in the treatment of primary dysmenorrhea by 16S rDNA sequencing and metabolomics

To explore the mechanism of acupoint application in the treatment of primary dysmenorrhea by 16S rDNA sequencing and metabolomics

The Relationship of the Dysmenorrhea a in Students with Learning Activities

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

Contact Info

Product

Resources

About