Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task

Bachiller, Alejandro; Lubeiro, Alba; Díez, Álvaro; Suazo, Vanessa; Domínguez, César; Garrote, J.A. Blanco; Ayuso, Marta; Hornero, Roberto; Poza, Jesús; Molina, Vicente

doi:10.1007/s00406-014-0525-5

Cited by 39 publications

(46 citation statements)

References 43 publications

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“…In contrast, P3b seems to be related to conscious top-down target processing, likely contributing to processing the stimulus information and performing cognitive response (Polich, 2007;Strobel et al, 2008). In previous reports, we found a blunted ERP modulation in Sz as response to both target (Bachiller et al, 2014) and distractor (Bachiller et al, 2015b) tones during an oddball paradigm. Thus, the analysis of the differences in neural pattern generators between Sz patients and healthy controls becomes an interesting research topic to clarify the neural substrate of reduced P300 amplitude in Sz.…”

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confidence: 47%

“…Controls were initially assessed by a semi-structured psychiatric interview to discard major psychiatric antecedents and treatments. Detailed description of treatments and doses, as well as exclusion criteria are detailed in previous reports (Bachiller et al, 2015a;Bachiller et al, 2015b). Symptoms were scored using the Positive and Negative Syndrome Scale (PANSS) (Kay et al, 1987).…”

Section: Subjectsmentioning

confidence: 99%

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Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach

Bachiller

Romero

Molina

et al. 2015

Schizophrenia Research

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The present study investigates the neural substrates underlying cognitive processing in schizophrenia (Sz) patients. To this end, an auditory 3-stimulus oddball paradigm was used to identify P3a and P3b components, elicited by rare-distractor and rare-target tones, respectively. Event-related potentials (ERP) were recorded from 31 Sz patients and 38 healthy controls. The P3a and P3b brain-source generators were identified by time-averaging of low-resolution brain electromagnetic tomography (LORETA) current density images. In contrast with the commonly used fixed window of interest (WOI), we proposed to apply an adaptive WOI, which takes into account subjects' P300 latency variability. Our results showed different P3a and P3b source activation patterns in both groups. P3b sources included frontal, parietal and limbic lobes, whereas P3a response generators were localized over bilateral frontal and superior temporal regions. These areas have been related to the discrimination of auditory stimulus and to the inhibition (P3a) or the initiation (P3b) of motor response in a cognitive task. In addition, differences in source localization between Sz and control groups were observed. Sz patients showed lower P3b source activity in bilateral frontal structures and the cingulate. P3a generators were less widespread for Sz patients than for controls in right superior, medial and middle frontal gyrus. Our findings suggest that target and distractor processing involves distinct attentional subsystems, both being altered in Sz. Hence, the study of neuroelectric brain information can provide further insights to understand cognitive processes and underlying mechanisms in Sz.

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confidence: 47%

Section: Subjectsmentioning

confidence: 99%

Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach

Bachiller

Romero

Molina

et al. 2015

Schizophrenia Research

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“…Distractor tones usually have the same frequency of occurrence as target tones. As subjects are asked to respond to target tones, distractor tones only possess a novelty component, while target tones are associated to both novelty and relevance [12]. Several methods have been used to analyze transient dynamics in neural activity during an auditory oddball task or during resting-state.…”

Section: Introductionmentioning

confidence: 99%

“…Several methods have been used to analyze transient dynamics in neural activity during an auditory oddball task or during resting-state. Such measures, of a time-dependent nature, include wavelet entropy [6,13], multiscale entropy [14], median frequency [12,15] and relative power (RP) [15], among others. Many of these studies have found widespread lower neural reorganization (i.e., transient dynamical reorganization of brain activity during an attentional process) for SCH subjects compared to controls during the active task response [6,12,15].…”

Section: Introductionmentioning

confidence: 99%

Exploring non-stationarity patterns in schizophrenia: neural reorganization abnormalities in the alpha band

et al. 2017

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Objective. The aim of this paper was to characterize brain non-stationarity during an auditory oddball task in schizophrenia (SCH). The level of non-stationarity was measured in the baseline and response windows of relevant tones in SCH patients and healthy controls. Approach. Eventrelated potentials were recorded from 28 SCH patients and 51 controls. Non-stationarity was estimated in the conventional electroencephalography frequency bands by means of KullbackLeibler divergence (KLD). Relative power (RP) was also computed to assess a possible complementarity with KLD. Main results. Results showed a widespread statistically significant increase in the level of non-stationarity from baseline to response in all frequency bands for both groups. Statistically significant differences in non-stationarity were found between SCH patients and controls in beta-2 and especially in the alpha band. SCH patients showed more nonstationarity in the left parieto-occipital region during the baseline window in the beta-2 band. A leave-one-out cross validation classification study with feature selection based on binary stepwise logistic regression to discriminate between SCH patients and controls provided an accuracy of 89.87% and area under ROC of 0.9510. Significance. KLD can characterize transient neural reorganization during an attentional task in response to novelty and relevance. Our findings suggest anomalous reorganization of neural dynamics in SCH during an oddball task. The abnormal frequency-dependent modulation found in SCH patients during relevant tones is in agreement with the hypothesis of aberrant salience detection in SCH. The increase in nonstationarity in the alpha band during the active task supports the notion that this band is involved in top-down processing. The baseline differences in the beta-2 band suggest that hyperactivation of the default mode network during attention tasks may be related to SCH symptoms. Furthermore, the binary stepwise logistic regression procedure selected features from both KLD and RP, supporting the idea that these measures can be complementary.

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“…P. Núñez was in receipt of a 'Promoción de empleo joven e implantación de la Garantía Juvenil en I+D+i' grant from 'Ministerio de Economía y Competitividad' and the University of Valladolid, J. Gomez-Pilar and A. Bachiller (i.e., a subcomponent of P300, a positive going-amplitude that peaks around 300 ms after a relevant stimulus) [5].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the non-stationarity of neural activity during an auditory oddball task in schizophrenia

Núñez

Poza

Gómez‐Pilar

et al. 2016

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Abstract-The aim of this study was to characterize brain dynamics during an auditory oddball task. For this purpose, a measure of the non-stationarity of a given time-frequency representation (TFR) was applied to electroencephalographic (EEG) signals. EEG activity was acquired from 20 schizophrenic (SCH) patients and 20 healthy controls while they underwent a three-stimulus auditory oddball task. The Degree of Stationarity (DS), a measure of the non-stationarity of the TFR, was computed using the continuous wavelet transform. DS was calculated for both the baseline [-300 0] ms and active task [150 550] ms windows of a P300 auditory oddball task. Results showed a statistically significant increase (p<0.05) in non-stationarity for controls during the cognitive task in the central region, while less widespread statistically significant differences were obtained for SCH patients, especially in the beta-2 and gamma bands. Our findings support the relevance of DS as a means to study cerebral processing in SCH. Furthermore, the lack of statistically significant changes in DS for SCH patients suggests an abnormal reorganization of neural dynamics during an oddball task.

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Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task

Cited by 39 publications

References 43 publications

Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach

Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach

Exploring non-stationarity patterns in schizophrenia: neural reorganization abnormalities in the alpha band

Analysis of the non-stationarity of neural activity during an auditory oddball task in schizophrenia

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