Decreased Erythrocyte Cholinesterase. Activity in Dementia

Chipperfield, Barbara; Newman, PaulM; Moyes, IsabelC.A

doi:10.1016/s0140-6736(81)90377-9

Cited by 30 publications

(11 citation statements)

References 9 publications

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“…We found that low ChE activity in lymphocytes was the best discriminator for AD, while most of previous studies measured ChE activity in erythrocytes or plasma [6,32,51,52]. Lymphocyte ChE was reduced from very early stages of AD.…”

Section: Discussionmentioning

confidence: 52%

“…However, in most cases the decrease did not have statistical significance when the level of significance was corrected for multiple comparisons. There are reports showing increase of BuChE activity associated to decreased AChE in AD patients [20,[32][33][34]. Increased BuChE activity could be a compensatory mechanism to substitute for AChE, although BuChE activity in the brain appears to be constitutive (rather than compensatory) in AChE knockout mice [19].…”

Section: Discussionmentioning

confidence: 99%

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Blood Cells Cholinesterase Activity in Early Stage Alzheimer’s Disease and Vascular Dementia

Bernhardi

Alarcón

Mezzano

et al. 2005

Dement Geriatr Cogn Disord

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Blood acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities have been studied as markers for Alzheimer’s disease (AD), but their usefulness as a disease marker is controversial. To determine cholinesterase (ChE) activity during AD progression and whether ChE changes associate to other dementias, ChE activity was measured in lymphocytes, erythrocytes and platelets. Subjects underwent extensive medical and neuropsychological examination. Both early-AD and AD patients had lower AChE activity in lymphocytes compared to control subjects (p < 0.0001). In contrast, erythrocyte AChE activity was higher in patients with vascular dementia (p = 0.004). Low ChE activity in lymphocytes was the best discriminator for AD. Because it was already low at very early stages of AD, ChE could be helpful as an early biomarker of differential diagnosis for the follow-up of patients during their early stages of cognitive impairment before a clinical dementia is established.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Blood Cells Cholinesterase Activity in Early Stage Alzheimer’s Disease and Vascular Dementia

Bernhardi

Alarcón

Mezzano

et al. 2005

Dement Geriatr Cogn Disord

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“…(1984) observed no alterations. Measurements of AChE activity on erythrocytes in patients with clinically diagnosed AD have led to reports of elevations (Chipperfield et at., 1981), decreases (Perry et ai., 1982;Smith et ai., 1982), or no alterations (Marquis et al, 1984). Finally, Adem et ai.…”

Section: Cerebral Spinal Fluid Ache and Other Peripheral Changesmentioning

confidence: 99%

Handbook of Psychopharmacology

Iversen¹,

Iversen²,

Snyder³

1988

608

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“…Chipperfield et al 26 suggested that decreased AChE activity in erythrocytes (RBC) might serve as a diagnostic aid in cases of dementia. In their preliminary study, they compared a group of 12 demented patients of various etiologies with 22 healthy controls and ten patients with other neuropsychiatric diagnoses (alcoholism, depression, Huntington's chorea).…”

Section: Cholinergic Systemmentioning

confidence: 99%