Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach

Correas, Ángeles; López‐Caneda, Eduardo; Beaton, Lauren E.; Holguı́n, Socorro Rodrı́guez; García-Moreno, LM; Antón-Toro, LF; Cadaveira, Fernando; Maestú, Fernando; Marinković, Ksenija

doi:10.1177/0269881118805498

Cited by 20 publications

(30 citation statements)

References 143 publications

(213 reference statements)

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“…Secondly, besides the increased resting (tonic) oscillations –mostly in the theta and beta bands- reported in both BDs and AUD individuals, decreased “active” (phasic) oscillations have also been observed in both groups –particularly in the theta band- during emotional/cognitive tasks ( Correas et al, 2019 , Kamarajan et al, 2004 , Pandey et al, 2016 , Holcomb et al, 2019 , Huang et al, 2018 , López-Caneda et al, 2017b ). Again, these similarities between BDs and AUDs dovetail with the idea that BD may lead to consequences analogue to those of AUD, a thesis already pointed out by some neuropsychological studies (e.g., Sanhueza et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Electroencephalographic signatures of the binge drinking pattern during adolescence and young adulthood: A PRISMA-driven systematic review

Almeida‐Antunes

Crego

Carbia

et al. 2021

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 99%

Electroencephalographic signatures of the binge drinking pattern during adolescence and young adulthood: A PRISMA-driven systematic review

Almeida‐Antunes

Crego

Carbia

et al. 2021

NeuroImage: Clinical

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“…Two independent cohorts of young, healthy, right‐handed adults participated in the two arms of this study as detailed below and described in previous companion publications 23,29,35 . One group comprised social drinkers who took part in an acute alcohol challenge/placebo experiment in a within‐subject design.…”

Section: Methodsmentioning

confidence: 99%

“…Fifty‐one first‐year students of the Complutense University of Madrid (Madrid, Spain) participated in both the MEG and MRI sessions 23 . They were assigned to a binge drinking (BD) group ( N = 25, 13 females) or to a light drinking (LD) group ( N = 26, 14 females) based on a questionnaire and a semistructured interview inquiring about their alcohol and other drug use.…”

Section: Methodsmentioning

confidence: 99%

“…Electrophysiological methods, comprising magnetoencephalography and electroencephalography (MEG/EEG), reflect postsynaptic neural currents directly, making them well suited for pharmacological studies 14 and granting them millisecond temporal resolution. Furthermore, these noninvasive direct measures are sensitive to differences in neural activity between binge drinkers (BDs) and light drinkers (LDs) in the absence of deficits in cognitive performance or neuropsychological impairments 10,11,23–25 …”

Section: Introductionmentioning

confidence: 99%

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Compensatory neuroadaptation to binge drinking: Human evidence for allostasis

et al. 2020

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Animal studies have established that acute alcohol increases neural inhibition and that frequent intoxication episodes elicit neuroadaptive changes in the excitatory/inhibitory neurotransmission balance. To compensate for the depressant effects of alcohol, neural hyperexcitability develops in alcohol use disorder and is manifested through withdrawal symptoms. It is unclear, however, whether neuroadaptive changes can be observed in young, emerging adults at lower levels of consumption in the absence of withdrawal symptoms. Here, we used an anatomically constrained magnetoencephalography method to assess cortical excitability in two independent sets of experiments. We measured early visual activity (1) in social drinkers during alcohol intoxication versus placebo conditions and (2) in parallel cohorts of sober binge drinkers (BDs) and light drinkers (LDs). Acute alcohol intoxication attenuated early sensory activity in the visual cortex in social drinkers, confirming its inhibitory effects on neurotransmission. In contrast, sober BDs showed greater neural responsivity compared with a matched group of LDs. A positive correlation between alcohol consumption and neural activity in BDs is indicative of cortical hyperexcitability associated with hazardous drinking. Furthermore, neural responsivity was positively correlated with alcohol intake in social drinkers whose drinking did not reach binge levels. This study provides novel evidence of compensatory imbalance reflected in the downregulation of inhibitory and upregulation of excitatory signaling associated with binge drinking in young, emerging adults. By contrasting acute effects and a history of BD, these results support the mechanistic model of allostasis. Direct neural measures are sensitive to synaptic currents and could serve as biomarkers of neuroadaptation.

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“…That is, binge drinkers had increased theta power (Correas et al, 2015;López-Caneda et al, 2017) and decreased alpha power (Correas et al, 2015) compared with the non-BD group. Also, in a study examining event-related theta power of binge drinkers and lighter drinkers, the higher the alcohol intake of binge drinkers, the lower the theta power during the visual targeting task (Correas et al, 2019). In other words, alternation of oscillation in binge drinkers was associated with worse performance on the visual targeting task.…”

Section: Introductionmentioning

confidence: 99%

Alterations of Functional Connectivity During the Resting State and Their Associations With Visual Memory in College Students Who Binge Drink

Kim

2020

Front. Hum. Neurosci.

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This study investigated the characteristics of neural oscillation and functional connectivity (FC) in college students engaging in binge drinking (BD) using resting-state electroencephalography (EEG). Also, the associations of visual memory, evaluated by the Rey-Osterrieth Complex Figure Test (RCFT), and neural oscillation with FC during the resting state were investigated. The BD (n = 35) and non-BD (n = 35) groups were selected based on scores of the Korean version of the Alcohol use disorders (AUDs) Identification Test and the Alcohol Use Questionnaire. EEG was performed for 6 min while the participants rested with eyes closed. The theta, lower-alpha, and upper alpha powers did not differ between the BD and non-BD groups. Concerning FC, the BD group exhibited stronger theta coherence than that of the non-BD group, and in the lower and upper alpha bands, the BD group showed stronger coherence in some areas but weaker coherence in others compared with the non-BD group. However, these significant results were not observed after Bonferroni correction. The BD group showed significantly lower delayed recall scores on the RCFT than did the non-BD group. A positive correlation between the left prefrontal-parietal-occipital midline connection and performance on the delayed recall of the RCFT was observed in the BD group. The present results could suggest that binge drinkers have alterations in brain FC, which may be related to their visual memory deficits.

show abstract

Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach

Cited by 20 publications

References 143 publications

Electroencephalographic signatures of the binge drinking pattern during adolescence and young adulthood: A PRISMA-driven systematic review

Electroencephalographic signatures of the binge drinking pattern during adolescence and young adulthood: A PRISMA-driven systematic review

Compensatory neuroadaptation to binge drinking: Human evidence for allostasis

Alterations of Functional Connectivity During the Resting State and Their Associations With Visual Memory in College Students Who Binge Drink

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