Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma

Recurrence and Poor Prognosis Following Resection of Small Hepatitis B-Related Hepatocellular Carcinoma Lesions Are Associated with Aberrant Tumor Expression Profiles of Glypican 3 and Osteopontin

“…Interestingly, CYP2E1 was induced following exposure to alcohol and acetone or in nonalcoholic steatohepatitis, but decreased expression of CYP2E1 in tumors has been reported to be associated with absence of a tumor capsule and poorly differentiated HCC. 39 GPC3, HSP70, adenylate cyclase-associated protein 2 (CAP2), and glutamine synthetase have been proposed as early molecular markers for HCC in Japan; GPC3 was assumed to be an oncofetal protein, a marker of liver regeneration that is inactive in normal adult liver. 40,41 GPC3 also functions as a secretory protein and has been used as a serum marker (cutoff: 300 ng/l, sensitivity 47.0%, and specificity 93.5%) in HBV-positive HCC patients.…”

Overexpression of CYP2E1 enhances sensitivity of HepG2 cells to Fas-mediated cytotoxicity

“…Recent studies on the relationship between HCC and CYP2E1 showed that decreased expression of CYP2E1 was associated with poor prognosis of hepatocellular carcinoma. 9 Hirose et al reported that the expression of CYP2E1 in adjacent nontumor tissues was higher than that in HCC and normal liver tissues. Histologically, the expression of CYP2E1 in tumor cells tended to decrease as the cells were less differentiated, and was the lowest in poorly differentiated HCC.…”

“…10,11 The absence or weak expression of CYP2E1 has been also found in several HCC cell lines. 9,12 Moreover, cytotoxicity induced by overexpression of CYP2E1 in HepG2, in which the level of CYP2E1 is originally very low, was reported. 13 These results suggested that differential expression of CYP2E1 may play an important role in HCC tumorigenesis; induction of CYP2E1 in HCC might result in cytotoxicity and favor HCC prognosis.…”

Association of CYP39A1, RUNX2 and Oxidized Alpha-1 Antitrypsin Expression in Relation to Cholangiocarcinoma Progression

“…Increased CYP2A6 expression and activity were also found in chronic inflammation-related disease including hepatocellular, bronchogenic, esophageal carcinomas and CCA (Crawford et al, 1998;Raunio et al, 1998;Godoy et al, 2002;Yongvanit et al, 2012a). Decreased activity of CYP enzymes has been found to be associated with oxidative stress, for example, CYP2E1 in CCA (Yongvanit et al, 2012a) and HCC (Ho et al, 2004). CYP39A1, a steroid 7α-hydroxylation enzyme, is capable of metabolizing 24-hydroxycholesterol (24-OH) which is a cholesterol oxidation product (Li-Hawkins et al, 2000).…”