Decreased Expression of Hepatic Low-Density Lipoprotein Receptor–Related Protein 1 in Hypothyroidism: A Novel Mechanism of Atherogenic Dyslipidemia in Hypothyroidism

Moon, Jae Hoon; Kim, Hyung Jun; Kim, Hyun Min; Choi, Sung Hee; Lim, Soo; Park, Young Joo; Jang, Hak Chul; Soo, Bong

doi:10.1089/thy.2012.0457

Cited by 27 publications

(24 citation statements)

References 46 publications

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“…In hypothyroidism, there is a decrease in the activity of hepatic lipase and cholesterol 7 alpha hydroxylase [34–36] . In addition, the expression of hepatic LRP1 decreased [37] . These alterations may be associated with elevated circulating remnant lipoproteins.…”

Section: Discussionmentioning

confidence: 99%

Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older

Yang

Wang

et al. 2016

J Biomed Res

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This study investigated whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40–77 years old) with TSH levels in the normal range (0.35–5.00 mU/L). Using 2.50 mU/L as the cut-off point of TSH level within the normal range, we divided subjects into the high-TSH (2.50–5.00 mU/L; n = 1,064) and low-TSH (0.35–2.50 mU/L; n = 1,292) group. The results showed that the mean levels of body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were higher in the high-TSH group and TSH levels were significantly positively correlated with BMI, LDL-C, TC, and FPG. The prevalence of central obesity, hypertriglyceridemia, low high density lipoprotein cholesterol (HDL-C), and high FPG (>5.60 mmol/L) was significantly higher in females and subjects with high-TSH levels. Metabolic syndrome was also more prevalent in the high-TSH group. People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of metabolic syndrome, compared with those with low-normal TSH levels, after adjusting for age and gender. In conclusion, high normal TSH is a risk factor for metabolic syndrome in people≥40 years old.

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Section: Discussionmentioning

confidence: 99%

Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older

Yang

Wang

et al. 2016

J Biomed Res

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“…Thus, TG is hydrolyzed by LPL-producing smaller particles known as remnants [15]. The hepatic receptors, which contain apo (E), recognizes and removes the CMs remnants [16]. The dietary cholesterol from the chylomicron remnant particles is thought to downregulate the hepatic LDL receptors.…”

Section: Overview Of Lipid Metabolismmentioning

confidence: 99%

“…The level of low-density lipoprotein cholesterol (LDL-C) regulated by the amount of LDL receptors. Defects in the LDL receptor molecule leads to hypercholesterolemia and myocardial infarction [16]. HDL particles take up cholesterol from the peripheral tissues and return it to the liver as cholesterol esters by the action of lecithin cholesterol acyltransferase (LCAT).…”

Section: Overview Of Lipid Metabolismmentioning

confidence: 99%

“…In hypothyroid patients, despite the reduced activity of HMG-CoA reductase, there is often an increase in the serum TC concentration, mainly due to raised levels of serum LDL-C and IDL cholesterol [4,14,16,[27][28][29][30]. This is caused by a reduction in LDL receptors [16] and the diminishing control by T3 over SREBP-2, crucial for the expression of LDL receptor [14]. THs increase the synthesis and mobilization of TGs stored in the adipose tissue, which is reflected as an increase in the concentration of non-esterified fatty acids [31].…”

Section: Hypothyroidism and Lipid Metabolismmentioning

confidence: 99%

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Altered Lipid Profile in Hypothyroidism: A Biochemical Viewpoint

Kundoor

Bashetti

et al. 2018

Asian J Pharm Clin Res

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Context: Overt hypothyroidism is the most common endocrine disorder associated with a decrease in 3,5,3’-triiodothyronine and 3,5,3’,5’-tetraiodothyronine levels and increase in thyroid-stimulating hormone (TSH) levels. Thyroid hormones (THs) regulate all major metabolic pathways. THs play an important role in the synthesis, metabolism, and transport of lipids. Thyroid failure is associated with various biochemical and molecular alterations. Hypothyroidism is the common cause of secondary dyslipidemia as well as cardiovascular risk.Objective: The present review focuses on alterations in lipid metabolism associated with hypothyroidism leading to cardiovascular risk.Methods: The data source is from PUBMED, Google Scholar, and EMBASE. The study is a part of our previous research in studying the variations in lipid profile and transaminases in overt hypothyroidism.Result: The serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), lipoprotein (a) (Lp[a]), and triglycerides are elevated in individuals with overt hypothyroidism. In addition, it was also observed that the endothelial dysfunction, normal/depressed systolic function, left ventricular diastolic dysfunction at rest, as well as systolic and diastolic dysfunction on effort was observed in hypothyroidism.Conclusion: THs play an important role in the regulation of lipid metabolism. Hypothyroidism is also linked with altered hemodynamics. The atherogenic lipid profile along with other predisposing factors may contribute to the coronary artery disease.

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“…Hipotiroidide dolaşımdan "remnant" klerensinde önemli olan reseptör ilişkili protein 1 [(LDL receptor releated protein 1 (LRP1)]'in karaciğerde ekspresyonunun azaldığı saptanmış ve bunun sonucunda karaciğer tarafından dolaşımdaki şilo-mikron "remnant"ların çekilmesindeki azalmanın aterogenezde etken faktörlerden biri olduğu vurgulanmıştır. 15 Ateroskleroz ve buna bağlı komorbid hastalıklar, SH'de aynı yaş kesitindeki ötiroidlere oranla daha sık görülmektedir. [16][17][18] Her türlü kardiyovasküler risk ve buna bağlı mortalite SH'de artmaktadır.…”

Section: Subkli̇ni̇k Hi̇poti̇roi̇di̇ni̇n Yaşam Süresi̇ne Etki̇si̇unclassified

The Issue of Subclinical Hypothyroidism: Should it be Treated or Not?

Yürekli¹,

Kabalak²,

Altiner³

2016

Turkiye Klinikleri J Endocrin

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Decreased Expression of Hepatic Low-Density Lipoprotein Receptor–Related Protein 1 in Hypothyroidism: A Novel Mechanism of Atherogenic Dyslipidemia in Hypothyroidism

Cited by 27 publications

References 46 publications

Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older

Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older

Altered Lipid Profile in Hypothyroidism: A Biochemical Viewpoint

The Issue of Subclinical Hypothyroidism: Should it be Treated or Not?

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