Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma

Dou, Zhichao; Li, Shaoming; Ren, Wenhao; Wang, Qibo; Liu, Jiacheng; Kong, Xinjuan; Gao, Ling; Zhi, Kangkang

doi:10.1111/odi.13094

Cited by 22 publications

(25 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, to the best of our knowledge, only 1 study, reported by Wang et al [20], analyzed the profiles of differentially-expressed circRNAs in OSCC patients. In addition, fewer than 20 articles have demonstrated that circRNA is related to the progression of OSCC [46][47][48][49][50][51][52][53]. For instance, Wang et al reported that circDOCK1 can inhibit OSCC cell apoptosis by regulating BIRC3 expression [46].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Wang et al reported that circDOCK1 can inhibit OSCC cell apoptosis by regulating BIRC3 expression [46]. Dou et al discovered hsa_circ_0072387 expression was reduced in OSCC samples and was related to the TNM stage in OSCC [51]. Sun et al found hsa_circ_001242 expression in OSCC was substantially downregulated compared to AHTs [52].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hsa_circ_0086414 Might Be a Diagnostic Biomarker of Oral Squamous Cell Carcinoma

Zhang

2020

Med Sci Monit

View full text Add to dashboard Cite

Departmental sources Background: Circular RNAs (circRNAs), a newly-discovered class of non-coding RNAs, have a significant role in the progression of cancers, but the effect of hsa_circ_0086414 in human oral squamous cell carcinoma (OSCC) is still unclear. Material/Methods: The circRNAs expression profile in OSCC tissue samples was assessed by high-throughput sequencing. The hsa_circ_0086414 expression level in 55 paired OSCC tissue samples and 2 kinds of OSCC cells was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Additionally, the correlation between the hsa_circ_0086414 expression and clinicopathological characteristics of individuals with OSCC was studied. We used receiver operating characteristic (ROC) curves to observe the hsa_circ_0086414 value of diagnosis in OSCC. The network of hsa_circ_0086414-miRNAs-mRNAs was constructed. Gene Ontology (GO), Disease Oncology (DO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were carried out based on sequencing data and bioinformatics predictions. Results: Hsa_circ_0086414 expression in OSCC tissue samples and OSCC cells was first discovered to be significantly downregulated compared with the adjacent healthy tissues (AHTs) and normal (HaCaT) cells, respectively. Moreover, its expression level was significantly correlated with stage in TNM, size of tumor, and lymph node metastasis. The area below the ROC curve was 0.749. Hsa_circ_0086414-miRNAs-mRNAs network analysis and GO, DO, and KEGG analyses all demonstrated that hsa_circ_0086414 is correlated with cancer progression to a certain extent. Conclusions: We discovered that hsa_circ_0086414 might be an essential diagnostic biomarker in OSCC. Furthermore, hsa_circ_0086414 could be a target for OSCC therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0086414 Might Be a Diagnostic Biomarker of Oral Squamous Cell Carcinoma

Zhang

2020

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…Su et al 17 postulated that hsa_circ_0055538 participated in OSCC progression via the p53 signaling pathway, and may thus be a prospective diagnostic biomarker. Similarly, Dou et al 18 suggested that decreased expression of the key circRNA hsa_circ_0072387 in OSCC could make it a potential diagnostic biomarker and therapeutic target in OSCC. Furthermore, Zhu et al 19 revealed that the hsa_circRNA_100533-miR-933-guanine nucleotide-binding protein axis affected the biological behavior of OSCC cells via a mechanism of competing endogenous RNAs (ceRNAs), suggesting that hsa_circRNA_100533 may also be a novel diagnostic biomarker and therapeutic target for OSCC.…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0003829 serves as a potential diagnostic predictor for oral squamous cell carcinoma

et al. 2020

View full text Add to dashboard Cite

Objective Increasing evidence suggests that circular RNAs (circRNAs) play a major role in tumorigenesis and cancer progression. This study aimed to identify aberrant expression of hsa_circ_0003829 in oral squamous cell carcinoma (OSCC) and to explore its clinical significance. Methods We conducted a prospective clinical study to examine the expression pattern of hsa_circ_0003829 in 60 paired OSCC and normal clinical samples and in cell lines using real-time quantitative polymerase chain reaction. We also evaluated the diagnostic value of hsa_circ_0003829 in OSCC based on receiver operating characteristic (ROC) curve analysis, and examined the relationships between hsa_circ_0003829 expression and clinicopathological features in patients with OSCC. We further used bioinformatics software CircInteractome ( https: //Circinteractome.nia.nih.gov/ ) to predict circRNA–microRNA interactions. Results Hsa_circ_0003829 was significantly downregulated in OSCC compared with adjacent normal tissues. The area under the ROC curve was 0.81. Low expression levels of hsa_circ_0003829 in OSCC tissues were negatively correlated with lymph node metastasis status and TNM stage. Conclusions Downregulated expression of has_circ_0003829 suggests that this may be a key circRNA in OSCC, and may serve as a prospective biomarker for the diagnosis of OSCC.

show abstract

“…MiR-145 and miR-29 are both tumor suppressor genes in OSCC. Shao et al found that miR-145 inhibited the growth of OSCC cells by targeting c-Myc and CDK6 27 , while miR-29-3p was also a predicted target of circ_0072387 in oral squamous cell carcinoma cells 28 . Further analysis revealed that miR-145-5p and miR-29b-3p could jointly target CPEB3, PAN2, RLIM, NEXMIF, CFL2 and PHACTR2.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC

Luo

Liu

Guo

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Studies have found that circRnA in exosomes is associated with oral squamous cell carcinoma (oScc) progression. In this study, we examined the expression of circ_0000199 in circulating exosomes from patients with oScc and its role in the evaluation of relapse and prognosis. Real-time quantitative reverse transcription-polymerase chain reaction was performed to assess circ_0000199 expression in circulating exosomes from 108 patients with OSCC and 50 healthy people. Gain-and loss-functional experiments were performed to assess the role of circ_0000199 on cell proliferation and apoptosis in OSCC cells. Our results showed that the high level of circ_0000199 in circulating exosomes was significantly associated with betel quid chewing, tumor size, lymphatic metastasis, and TNM stage in patients with OSCC. In addition, the patients with high exosomal circ_0000199 had higher tumor recurrence rate and higher mortality rate than the patients with low exosomal circ_0000199. Overexpression of circ_0000199 promoted, while knockdown of circ_0000199 inhibited OSCC cell growth. Bioinformatics analysis predicted that circ_0000199 interacted with miR-145-5p and miR-29b-3p simultaneously, which were involved in multiple tumor-related signaling pathways. in conclusion, upregulation of circ_0000199 in circulating exosomes from patients with OSCC is positively associated with poor survival outcome. Circulating exosomal circ_0000199 can be used as a biomarker and potential therapeutic target for oScc. Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the world, accounting for 3% of malignant tumors 1. Although the treatment of OSCC has made breakthroughs in the past decades, the 5-year mortality rate is still less than 50% 2. Early diagnosis and early treatment are the keys to improve the survival rate of patients with OSCC. Exosomes have phospholipid bilayer membrane with the markers TSG101 and CD63. The size of exosomes ranges from 30 to 100 nm. These vesicles exist in almost all body fluids of the human body, including blood, serum, saliva, cerebrospinal fluid, and urine 3. Exosomes contain various substances, such as proteins, DNA, microRNA (miRNA), circular RNA (circRNA). These molecules can be transported to regulate the signaling pathways of the recipient cells 4. CircRNAs are covalently formed from the ends of a single RNA molecule, without 5′ and 3′ ribonucleotide end, and circRNAs are expressed abundantly, conserved and stably in cells with temporal and spatial specificity 5. CircRNAs can bind to miRNAs to inhibit their functions. Therefore, circRNA is also called miRNA sponge. With the continuous understanding of circRNA, researchers have found that circRNAs are widely involved in the occurrence and development of physiology and disease as well as tumors 6. As a new type of regulatory endogenous RNA, circRNAs are expected to become a tumor diagnostic marker and therapeutic target due to its characteristics such as stability, conservation, and tissue-specific expression 7. For example, circRNA_...

show abstract

Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma

Cited by 22 publications

References 25 publications

Hsa_circ_0086414 Might Be a Diagnostic Biomarker of Oral Squamous Cell Carcinoma

Hsa_circ_0086414 Might Be a Diagnostic Biomarker of Oral Squamous Cell Carcinoma

Hsa_circ_0003829 serves as a potential diagnostic predictor for oral squamous cell carcinoma

Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC

Contact Info

Product

Resources

About