Decreased expression of human heat shock protein 70 in the endometria and pathological lesions of women with adenomyosis and uterine myoma after GnRH agonist therapy

Khan, Khaleque Newaz; Kitajima, Michio; Hiraki, Koichi; Fujishita, Akira; Nakashima, Masahiro; Masuzaki, Hiroaki

doi:10.1016/j.ejogrb.2015.01.012

Cited by 18 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GnRH-a treatment with add-back estrogen therapy is used for AD and has resulted in reports of several (51), and treatment has a positive effect on endometrial implantations markers (52). AD was not associated with a lower PR in the pooled data from two studies (33,35) in which a long protocol (GnRH-a) was adopted.…”

Section: Gonadotropin-releasing Hormone Analog (Gnrh-a) Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Uterine adenomyosis and infertility, review of reproductive outcome after in vitro fertilization and surgery

Dueholm

2017

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

This review includes an analysis of the clinical studies evaluating reproductive outcome and adenomyosis, and a review of studies on reproductive outcome and surgical treatment options for adenomyosis. Strict diagnostic criteria and classification of disease are needed for an image diagnosis of adenomyosis. Studies of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) populations and women with surgically treated deep endometriosis have suggested that adenomyosis has a negative impact on reproductive outcome, although there are substantial variations between studies. Few data are available on the relation between the extent of disease and impact on reproductive outcome, but a correlation appears to exist. Case series seem to confirm a positive effect of gonadotropin-releasing hormone analog treatment and surgery on reproductive outcome, but there are no controlled trials. Evidence is impaired by the poor quality of many studies, a lack of strict image diagnosis, and the absence of a classification of the extent of disease. Selection of the optimal evidence-based treatment options for adenomyosis in the fertility clinic is difficult because of a lack of evidence regarding the relation between fertility and the degree and composition of adenomyosis. Adenomyosis may reduce implantation so severely that surgical or other treatment options should be recommended, but the benefit of these treatment options needs to be verified. Referral of women with adenomyosis and recurrent miscarriage and repeated failure of assisted reproductive technology to centers with a special interest in adenomyosis research and treatment may be critical.

show abstract

Section: Gonadotropin-releasing Hormone Analog (Gnrh-a) Treatmentmentioning

confidence: 99%

“…GnRH‐a treatment with add‐back estrogen therapy is used for AD and has resulted in reports of several pregnancies . GnRH‐a treatment decreases the size and demarcation of adenomyotic lesions, as demonstrated by MRI , and treatment has a positive effect on endometrial implantations markers .…”

Section: Treatment Of Adenomyosis In the Infertile Patientsmentioning

confidence: 99%

Uterine adenomyosis and infertility, review of reproductive outcome after in vitro fertilization and surgery

Dueholm

2017

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…17 The use of it have also played a positive role on the markers of endometrial implantation. 18 It is believed to decrease the size of Adenomyotic lesion, while the AD patients who underwent frozen embryo transfer whose endometrium was prepared with long term (GnRH-a) therapy before the Implantation showed better pregnancy rate in comparison to those in whom pre-treatment with (GnRHa) was not given. 19…”

Section: Reproductive Outcomes Of Adenomyosis After Surgerymentioning

confidence: 99%

Adenomyosis and its impact on fertility

Khan

Wang

2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Adenomyosis is an estrogen dependent benign gynecological disease affecting women of reproductive age causing them to have an adverse effect. Symptoms in these patients include pelvic pain, menorrhagia, abnormal uterine bleeding and infertility. It has a negative impact on a woman’s reproductive ability. The gold standard treatment for adenomyosis is hysterectomy for whom fertility is not an issue and for whom future pregnancy has no concerns, however females who wish to retain uterus for child bearing purposes the treatment seems to be very challenging. In this literature we will focus on how adenomyosis affects the reproductive outcome in women and what is its impact on the pregnancy rate also we will enlighten the pregnancy outcomes and pregnancy rate in patient with adenomyosis after various treatment Including the medical, surgical and in-vitro fertilization.

show abstract

“…Gonadotropin-releasing hormone analog (GnRH-a) treatment with add-back estrogen therapy is used for AD and has resulted in reports of several pregnancies [19]. GnRH-a treatment decreases the size and demarcation of adenomyotic lesions, and treatment has a positive effect on endometrial implantations markers [20]. The therapy may produce a window of time with improved implantation rates.…”

Section: Medical Treatmentmentioning

confidence: 99%