Decreased expression of <i>DFF45</i>/ICAD is correlated with a poor prognosis in patients with esophageal carcinoma

Konishi, Shigeru; Ishiguro, Hideyuki; Shibata, Yasuyuki; Kudo, Junzo; Terashita, Yukio; Sugiura, Hironori; Koyama, Hiroshi; Kimura, Masahiro; Satō, Atsushi; Shinoda, Noriyuki; Kuwabara, Yoshiyuki; Fujii, Yoshitaka

doi:10.1002/cncr.10987

Cited by 37 publications

(37 citation statements)

References 95 publications

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“…In esophageal cancer, prognostic markers such as E-cadherin, MDM2 and HGF have been reported (21)(22)(23). We previously showed that expression of DNA fragmentation factor 45, excision repair cross complementing 3, and PABPC1 may be prognostic markers for ESCC (24)(25)(26). Girdin may now be added to this list.…”

Section: Discussionmentioning

confidence: 98%

Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma

et al. 2013

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Abstract. Girdin, an actin-binding Akt substrate, regulates actin reconstruction and Akt-dependent cell motility in fibroblasts and in a human breast cancer cell line. We examined whether Girdin is also involved in the motility of esophageal squamous cell carcinoma (ESCC) cells. Immunofluorescent staining and migration assays were performed, using KYSE cell lines, to examine whether Girdin is involved in the motility of ESCC cells. Upon EGF stimulation, Girdin colocalized with filamentous actin (F-actin) in the lamellipodia as determined by immunofluorescent staining. In migration assays, cell motility was significantly reduced in KYSE cell lines transfected with Girdin siRNA compared with the negative control. In addition, we examined the relationship between Girdin expression and clinical data, using specimens resected from ESCC patients. In immunohistochemical (IHC) analyses using specimens resected from ESCC patients, overall survival was significantly longer in cases showing lower Girdin expression compared to cases with higher Girdin expression. Collectively, Girdin appears to be involved in the motility of ESCC cells. The levels of Girdin expression correlated inversely with the survival of ESCC patients. Therefore, in ESCC, Girdin may be a prognostic marker and may serve as a therapeutic target as well.

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Section: Discussionmentioning

confidence: 98%

Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma

et al. 2013

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“…Recent molecular biological studies have revealed that ESCC is caused by the accumulation of multiple genetic defects in dominant oncogenes and tumor suppressors. We have also reported the expression of surviving (1), DFF45/ICAD (2), PTTG (3), Chfr (4), PPARγ (5), ERCC3 (6), PABPC1 (7) and ACP6 (8) to significantly correlate with the tumor progression and prognosis in patients with ESCC.…”

Section: Introductionmentioning

confidence: 84%

The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma

Ando

Ishiguro²,

Kimura³

et al. 2007

Oncol Rep

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Abstract. Caveolin-1 (CAV1) and caveolin-2 (CAV2) are the major structural proteins of caveolae. We investigated the relationship between the clinicopathological factors of esophageal squamous cell carcinoma (ESCC) and the expression of CAV1 and CAV2. CAV1 and CAV2 expression were analyzed by quantitative reverse transcription-polymerase chain reaction (RT-PCR) in 15 esophageal cancer cell lines (TE1-15) and a normal esophageal epithelium cell line (Het-1A). CAV1 and CAV2 expression was examined by RT-PCR and immunohistochemical analysis in 47 ESCC specimens. High levels of CAV1 and CAV2 mRNA were detected in TE1-15, but neither CAV1 nor CAV2 mRNA were detected in Het-1A. In the ESCC samples CAV1 and CAV2 mRNA expression in the ESCC samples were significantly higher than in the corresponding normal esophageal mucosa (CAV1, P=0.0024; CAV2, P=0.0136). However, we could not find any significant relationship between CAV1 or CAV2 mRNA expression and clinicopathological factors. Immunostaining for CAV1 was positive in 13 of 47 patients (27.7%), whereas CAV2 was positive in 22 of 47 patients (46.8%). A significant correlation was observed between CAV1 and CAV2 immunostaining and T factor, lymphatic invasion, vein invasion and differentiation. The patients with positive staining for CAV1 or CAV2 had a significantly shorter survival than those with negative staining (P=0.0105 and 0.0424 for CAV1 and CAV2, respectively). These results suggest that positive staining for CAV1 and CAV2 could be a potentially useful prognostic marker of ESCC.

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“…Decreased DFF45 expression is shown to associate with higher-stage neuroblastoma (Abel et al, 2002) and a poorer prognosis in some cancer patients (Konishi et al, 2002). DFF40/45 is also a candidate tumor suppressor for neuroblastomas.…”

Section: Introductionmentioning

confidence: 99%

Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner

et al. 2006

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Decreased expression of DFF45/ICAD is correlated with a poor prognosis in patients with esophageal carcinoma

Cited by 37 publications

References 95 publications

Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma

Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma

The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma

Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner

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