Decreased expression of IL-33 in immune thrombocytopenia

Li, Peipei; Zhang, Xiaomei; Yuan, Ding; Liu, Xin; Li, Ying; Shan, Ning-ning

doi:10.1016/j.intimp.2015.06.035

Cited by 10 publications

(8 citation statements)

References 46 publications

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“…This agreed with (15) who aimed to measure the expression of IL-33 in active immune thrombocytopenia (ITP) compared to controlsThirty-two ITP patients measured in plasma using ELISA and compared with 27 age-and sex-matched healthy controls.IL-33 in the ITP patients with active disease were significantly lower than those of the healthy controls. Significantly lower IL-33 and higher sST2 plasma levels were found in the active ITP patients compared with the ITP patients in .However, no significant differences in the IL-33 and sST2 plasma levels were found between the ITP patients in remission and healthy controls.…”

Section: )supporting

confidence: 74%

“…However, there was no significant difference between the patients in remission and normal controls. (15) CONCLUSION This study concluded that, IL-33 may contribute to the pathogenesis of ITP. It could be a potential biomarker that diagnose and…”

Section: )mentioning

confidence: 67%

“…Additional advantages of ELISA include the fact that results are highly quantitative and generally reproducible. (15) This study showed that, mean value of IL-33 was significantly lower among cases than controls (24.68, 47.18 respectively).There was statistically decrease of IL-33 among acute ITP children than chronic ITP children (P value=.000).There was statistically decrease of IL-33 among acute ITP children than controls (P value=.000).There was no statistically significant difference between chronic ITP children and controls regarding IL-33 (P value=.769).…”

Section: )mentioning

confidence: 99%

“…While There were statistically significant positive correlation between IL-33 ,WBCs, lymphocytes % and Platelets . (15) made correlations between the plasma IL-33 and platelet counts were analyzed in the active ITP patients. The data demonstrated no correlation between the IL-33 levels and platelet counts.…”

Section: )mentioning

confidence: 99%

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Study of Interleukin-33 in Idiopathic Thrombocytopenic Purpura in Children

Khalifa¹,

Hesham²,

Shaaban³

et al. 2019

Zagazig University Medical Journal

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Background: Immune thrombocytopenia (ITP) is an immune-mediated hematologic disorder in which increased platelet destruction and decreased platelet production lead to thrombocytopenia and, thus, mucocutaneous bleeding. The interleukin-1 (IL-1) family is involved in many human diseases by regulating innate immunity and inflammation. As a new IL-1 family member found in 2005, IL-33 and its receptor play important roles in inflammation, cancer, allergy and autoimmune diseases and are potential therapeutic targets. The aim of this work was to evaluate IL-33 among active ITP patients and remission in relation to control. Methods: This is a case control study This study was conducted in the Outpatient Clinic of Hematology Unit of Pediatric Department and Clinical Pathology Department at Zagazig university hospitals during the period from October 2017 to April 2018, on Twenty two ITP Patients during their regular follow-up visits and Twenty two age and sex-matched healthy children as a control group. Forty four subjects were included in this study; they were classified into two groups as follow: Control group and Patient group: Each group was subjected to the following: History, examination and Laboratory workup including IL-33.Results: There was no statistically significant difference between cases and control regarding sex and age.Purpura, ecchymosis and mucous membrane bleeding (90.9%,81.81% and72.7% respectively) were the most common clinical data among ITP cases group. Less common splenomegaly and lymphadenopathy were (4.54% and .0%) respectively. There was no statistically significant difference between cases and control regarding HB, RBCs, WBCs and lymphocytes %.Mean value of Platelets was significantly lower among cases than controls (28.14, 288.64 respectively) P=.000.Mean value of IL-33 was significantly lower among cases than controls (24.68, 47.18 respectively) P=.000.There was statistically significant difference between acute ITP patients and chronic ITP patients regarding IL-33 (P value=.000).There was statistically significant difference between acute ITP patients and controls regarding IL-33 (P value=.000).There was no statistically significant difference between chronic ITP patients and controls regarding IL-33 (P value=.769).There were no statistically significant positive correlation between IL-33 and [age (r=.057, P=.714), HB (r=.095, P=.540) and RBCs (.249, P=.103]. While There were statistically significant positive correlation between IL-33 and [WBCs (r=.398, P=.008), lymphocytes % (r=.377, P=.012) and Platelets (r=.537, P=.000).Conclusion: This study concluded that, IL-33 may contribute to the pathogenesis of ITP. It could be a potential biomarker that diagnose and provide a new therapeutic target for ITP therapy.

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Section: )supporting

confidence: 74%

Section: )mentioning

confidence: 67%

Section: )mentioning

confidence: 99%

Section: )mentioning

confidence: 99%

See 2 more Smart Citations

Study of Interleukin-33 in Idiopathic Thrombocytopenic Purpura in Children

Khalifa¹,

Hesham²,

Shaaban³

et al. 2019

Zagazig University Medical Journal

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“…It might play a pivotal role in the coagulopathy mechanism of DENV infections. One study [29] claimed that IL-33 expression decreased in patients with immune thrombocytopenia. IL-33 increases cell surface tissue factor, a major trigger of coagulation, and it significantly reduces the coagulation time of human whole blood and plasma samples [30].…”

Section: Discussionmentioning

confidence: 99%

Dynamic changes of soluble ST2 levels predicted fatality and were involved in coagulopathy in dengue fever in the elderly

Hsieh

Hong

et al. 2019

PLoS Negl Trop Dis

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BackgroundSevere dengue virus (DENV) infection involves plasma leakage and vascular collapse, and leads to significant morbidity and death. Serum soluble ST2 (sST2 [interleukin (IL)-1 receptor like-1 protein: IL-1-RL-1]) levels are high in pediatric cases of DENV infection, and the disease progresses. However, the correlation between serum sST2 levels and the outcomes of DENV infection in the elderly (�65 years) is unclear. We thus explored the mechanisms of serial sST2 level changes involved in the coagulopathy and bloodstream infections of elderly patients in Taiwan's 2015 DENV outbreak. MethodsThis retrospective study was done in a tertiary medical center in southern Taiwan during the outbreak. All DENV-infected patients who, between July 1, 2015, and December 31, 2015, provided a written informed consent for at least two blood sample analyses were enrolled and reviewed. The serum levels of sST2 were quantified. ΔsST2 is defined as the "changes of sST2 levels in serially paired samples". Receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) analyses were used to evaluate the prognostic ability of ΔsST2. ResultsForty-three patients with DENV infection were enrolled. Mean patient age was 75.0 ± 12.2 years and the case fatality rate was 44.2% (19/43). Significantly more non-survivors than survivors had increased ST2 level (78.9% vs. 12.5%, p < 0.001). The AUC value for serum ΔsST2 level was 0.857 for predicting DENV fatality. Moreover, patients given frozen fresh plasma (FFP) transfusions were significantly (p = 0.025) more likely to have higher serum ST2 level changes than were those who had not. DENV-infected patients with early

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Genetic variants in IL-33/ST2 pathway with the susceptibility to hepatocellular carcinoma in a Chinese population

Wei

Huang

et al. 2019

Cytokine

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Decreased expression of IL-33 in immune thrombocytopenia

Cited by 10 publications

References 46 publications

Study of Interleukin-33 in Idiopathic Thrombocytopenic Purpura in Children

Study of Interleukin-33 in Idiopathic Thrombocytopenic Purpura in Children

Dynamic changes of soluble ST2 levels predicted fatality and were involved in coagulopathy in dengue fever in the elderly

Genetic variants in IL-33/ST2 pathway with the susceptibility to hepatocellular carcinoma in a Chinese population

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