Decreased expression of microRNA‑30b promotes the development of pulpitis by upregulating the expression of interleukin‑6 receptor

Zhang, Ning; Zhang, Qingwei; Yang, Weidong; Miao, Leiying; Wang, Nannan; Wei, Shanjing; Ge, Jianli; Li, Xin; Wu, Juan

doi:10.3892/etm.2019.7280

Cited by 8 publications

(8 citation statements)

References 43 publications

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“…In line with this outcome, a previous research has given out evidence that as a circulating inflammation‐related miRNA, miR‐30d‐5p expression was in negative correlation with levels of IL‐6 and IL‐1, thereby regulating the inflammatory reaction in patients with systemic inflammatory response syndrome . From the opposite angle, Zhang et al have discovered that degradation of miR‐30b has capacity to exacerbate progression of pulpitis by promoting the level of IL‐6 . Furthermore, we have also unveiled that amplification of miR‐30b and miR‐30d suppressed the oxidative stress in FHF mice by inhibiting MDA and improving levels of GSH, SOD, CAT, and GSH‐Px.…”

Section: Discussionsupporting

confidence: 78%

“…31 From the opposite angle, Zhang et al have discovered that degradation of miR-30b has capacity to exacerbate progression of pulpitis by promoting the level of IL-6. 32 Furthermore, we have also unveiled that amplification of miR-30b and miR-30d suppressed the oxidative stress in FHF mice by inhibiting MDA and improving levels of GSH, SOD, CAT, and GSH-Px. In accordance with this finding, a published document has unearthed that up-regulated miR-30b improved expression of CAT, thus promoting the cytoprotective mechanism against oxidative stress in retinal pigment epitheliums.…”

Section: Discussionmentioning

confidence: 82%

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Up‐regulation of microRNA‐30b/30d cluster represses hepatocyte apoptosis in mice with fulminant hepatic failure by inhibiting CEACAM1

et al. 2020

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Recently, impacts of microRNAs have been unraveled in human diseases, and we aimed to confirm the role of miR‐30b/30d in fulminant hepatic failure (FHF). Expression of miR‐30b/30d and CEACAM1 in serum of FHF patients and healthy people was measured by reverse transcription quantitative polymerase chain reaction (RT‐qPCR) and Western blot analysis. Mice FHF models were established by injection of D‐Galn and lipopolysaccharide, and were treated with miR‐30b/30d mimics. Oxidative stress, liver injury, and inflammatory reaction in mouse liver tissues were measured using oxidative stress‐related factor kits, hematoxylin–eosin staining and enzyme‐linked immunosorbent assay, respectively. Moreover, cell cycle distribution and apoptosis of hepatocytes of mice were determined by flow cytometry, and the target relation between miR‐30b/30d and CEACAM1 was confirmed by bioinformatic method and dual luciferase reporter gene assay. MiR‐30b/30d expression was positively, and CEACAM1 expression was negatively related to prognosis of FHF patients. Up‐regulation of miR‐30b/30d attenuated oxidative stress, liver injury, and inflammatory reaction, and improved survival rate of FHF mice. Furthermore, elevated miR‐30b/30d ameliorated apoptosis and cell cycle arrest of hepatocytes of FHF mice. CEACAM1 was a target gene of miR‐30b/30d. This study highlights that up‐regulated miR‐30b/30d attenuates the progression of FHF by targeting CEACAM1, which may be helpful to FHF treatment.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 82%

Up‐regulation of microRNA‐30b/30d cluster represses hepatocyte apoptosis in mice with fulminant hepatic failure by inhibiting CEACAM1

et al. 2020

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“…This data demonstrates that in response to Pg LPS, human pulp fibroblasts downregulate expression of miR-181a, which subsequently increases expression of IL-8. Another similar study used a combination of in vivo and in vitro approaches to examine the role of miR-30b in pulpitis 19 . This study reported lower levels of miR-30b and increased levels of IL-6 protein and mRNA in inflamed human pulps as compared to normal controls.…”

Section: Micrornas (Mirnas) In the Pulpal Response To Infectionmentioning

confidence: 99%

Non-coding RNAs in endodontic disease

Galicia

Khan

2022

Seminars in Cell & Developmental Biology

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“…In this context, Naqvi et al reported that miR-30b was found to be downregulated during the differentiation from monocytes to macrophages (Mϕ) and from monocytes to dendritic cells (DCs), and that its overexpression was capable to attenuate the phagocytosis by myeloid inflammatory cells, as well as the production of pro-inflammatory cytokines, such as IL-6, IL-12, and TNF-α [142]. Regarding the role of miR-30b in pulp inflammation, there is only one study, which reported that miR-30b was downregulated in pulp tissue, plasma, and saliva, in patients with dental pulpitis, while levels of the IL-6R and IL-6 mRNA remained high, responding to inflammatory processes [143]. These findings show that miR-30b regulates the expression of IL-6R, which can affect the progression of pulpitis through it, so it can be a potential biomarker for the diagnosis of pulpitis.…”

Section: Mir-30bmentioning

confidence: 99%

The Role of microRNAs in Pulp Inflammation

Muñoz‐Carrillo

Vázquez-Alcaraz

Vargas-Barbosa

et al. 2021

Cells

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The dental pulp can be affected by thermal, physical, chemical, and bacterial phenomena that stimulate the inflammatory response. The pulp tissue produces an immunological, cellular, and vascular reaction in an attempt to defend itself and resolve the affected tissue. The expression of different microRNAs during pulp inflammation has been previously documented. MicroRNAs (miRNAs) are endogenous small molecules involved in the transcription of genes that regulate the immune system and the inflammatory response. They are present in cellular and physiological functions, as well as in the pathogenesis of human diseases, becoming potential biomarkers for diagnosis, prognosis, monitoring, and safety. Previous studies have evidenced the different roles played by miRNAs in proinflammatory, anti-inflammatory, and immunological phenomena in the dental pulp, highlighting specific key functions of pulp pathology. This systematized review aims to provide an understanding of the role of the different microRNAs detected in the pulp and their effects on the expression of the different target genes that are involved during pulp inflammation.

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Decreased expression of microRNA‑30b promotes the development of pulpitis by upregulating the expression of interleukin‑6 receptor

Cited by 8 publications

References 43 publications

Up‐regulation of microRNA‐30b/30d cluster represses hepatocyte apoptosis in mice with fulminant hepatic failure by inhibiting CEACAM1

Up‐regulation of microRNA‐30b/30d cluster represses hepatocyte apoptosis in mice with fulminant hepatic failure by inhibiting CEACAM1

Non-coding RNAs in endodontic disease

The Role of microRNAs in Pulp Inflammation

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