Decreased expression of PPARγ is associated with aortic endothelial cell apoptosis in intermittently hypoxic rats

Lian, Ningfang; Chen, Mengxue; Zhang, Shuyi; Chen, Li-Da; Huang, Jiefeng; Lin, Qi‐Chang

doi:10.1007/s11325-021-02319-x

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…Peroxisome proliferator-activated receptor gamma (PPAR-γ) was found to be a possible target of miRNA-130 -PPAR-γ might regulate adipocyte differentiation and promote both oxidative stress injury and proinflammatory response (Kim et al, 2013;Zhang Y. et al, 2017). Especially in a chronic intermittent hypoxic environment, PPAR-γ is in charge of neuroinflammation development and cognitive performance (Dong et al, 2018;, endothelial cell regulation (Lian et al, 2021), and defense from the kidney (Zhang et al, 2019) or cardiac (Pai et al, 2022) injury. Nocturnal hypercapnia, another hallmark of OSA, can contribute to obesity and metabolic impairment through PPAR-γ dysregulation (Kikuchi et al, 2017).…”

Section: Osamentioning

confidence: 99%

The role of microRNAs in pathophysiology and diagnostics of metabolic complications in obstructive sleep apnea patients

Karuga,

Jaromirska,

Malicki

et al. 2023

Front. Mol. Neurosci.

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Obstructive sleep apnea (OSA) is one of the most common sleep disorders, which is characterized by recurrent apneas and/or hypopneas occurring during sleep due to upper airway obstruction. Among a variety of health consequences, OSA patients are particularly susceptible to developing metabolic complications, such as metabolic syndrome and diabetes mellitus type 2. MicroRNAs (miRNAs) as epigenetic modulators are promising particles in both understanding the pathophysiology of OSA and the prediction of OSA complications. This review describes the role of miRNAs in the development of OSA-associated metabolic complications. Moreover, it summarizes the usefulness of miRNAs as biomarkers in predicting the aforementioned OSA complications.

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