Decreased expression of SOX17 is associated with tumor progression and poor prognosis in breast cancer

Fu, Deyuan; H, Tan; Wei, Jinli; Zhu, Changren; Jiang, Jixin; Zhu, Yu Cheng; Cai, Fenglin; Chong, Meihong; Ren, Chuanli

doi:10.1007/s13277-015-3547-3

Cited by 25 publications

(11 citation statements)

References 36 publications

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“…Thus, it is necessary to develop new prognostic tools and effective therapeutics that may be bene cial for improving the clinical management of oral cancer. In the recently studies, application of prognostic biomarkers has directed the research in the tumor studies [25,26]. For example, Xu et al have found that bulin-5 could serve as an independent prognostic factor and promote the proliferation and invasion in glioma [27].…”

Section: Discussionmentioning

confidence: 99%

Overexpression of Keratin17 is Associated With Prognosis of Oral Cancer in the Chinese Population

Wang

Song

Yang

2020

Preprint

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Background: Oral cancer represents an common cancer among head and neck malignancies. The early metastasis contributes the poor prognosis of this disease. Keratin (KRT) family has ever been found to be involved in some crucial biological processes in normal cells and human cancer cells. As a member of this family, keratin 17 (KRT17) has been studied in some different cancers. In the present study, we aimed at assess the prognostic value of KRT17 in patients with oral cancer.Methods: Expression of KRT17 in 135 paired oral cancer tissues and noncancerous tissues was estimated by using quantitative Real-Time RT-PCR (qRT-PCR). The prognostic value of KRT17 was assessed with Kaplan-Meier survival analysis and multivariate Cox regression analysis.Results: Upregulated expression of KRT17 was detected in oral cancer tissues compared with the matched normal tissues (P<0.001). The expression of KRT17 was found associated with lymph node metastasis (P=0.025) and clinical stage (P=0.005). The Kaplan-Meier survival curves showed that the patients with high KRT17 expression possessed worse overall survival than those with low level cases (log-rank P=0.000). From the data of Cox analysis, we considered the KRT17 expression was an independent prognostic biomarker in oral cancer patients with HR of 2.489, 95% CI of 1.333-4.648 and P of 0.004.Conclusion: In summary, the expression of KRT17 was found upregulated in oral cancer tissue specimens and it was proved to serve as an independent prognostic biomarker in patients with oral cancer.

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Section: Discussionmentioning

confidence: 99%

Overexpression of Keratin17 is Associated With Prognosis of Oral Cancer in the Chinese Population

Wang

Song

Yang

2020

Preprint

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“…For instance, Fu et al demonstrated that SOX17 expression was downregulated and correlated with the poor prognosis of breast cancer. 21 MicroRNA-106b, another example, has been proved to be involved in the recurrence of breast cancer and to act as an independent prognostic factor in patients with breast cancer. 22 Jerzak et al reported that the thyroid hormone receptor α ( THRα ) represented an efficient prognostic biomarker in breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of <em>HDAC9</em> is associated with poor prognosis and tumor progression of breast cancer in Chinese females

Huang¹,

Wei²,

Zhao³

et al. 2018

OTT

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BackgroundBreast cancer represents a serious health issue among females. HDAC9 has been identified as an oncogene in human cancers. This study sought to assess the prognostic value and the biologic function of HDAC9 in breast cancer patients.MethodsExpression of HDAC9 in breast cancer tissues and cells was evaluated by quantitative real-time polymerase chain reaction. Kaplan–Meier survival analysis and Cox regression assay were conducted to explore the prognostic significance of HDAC9. Cell experiments were performed to investigate the effects of HDAC9 on the biologic behaviors of breast cancer cells.ResultsExpression of HDAC9 was significantly upregulated in both cancerous tissues and cells compared with the normal controls (all P<0.05). Overexpression of HDAC9 was correlated with lymph node metastasis (P=0.021) and TNM stage (P=0.004). Patients with high HDAC9 had poor overall survival compared to those with low levels of HDAC9 (log-rank P<0.05). Elevated HDAC9 was found to be an independent prognostic factor for the patients (hazard ratio=2.996, 95% CI=1.611–5.572, P=0.001). According to the cell experiments, tumor cell proliferation, migration and invasion were suppressed by knockdown of HDAC9.ConclusionAll data demonstrated that overexpression of HDAC9 serves as a prognostic biomarker and may be involved in the tumor progression of breast cancer.

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“…Yeh et al reported that granulin is an important prognostic biomarker and potential therapeutic target in breast cancer [22]. Fu et al indicated that SRY-related HMG-box ( SOX17 ) is associated with breast cancer progression and can act as a useful prognostic biomarker [23]. Pelkonen et al claimed that hepsin and TMPRSS3 can serve as prognostic markers in breast cancer [24].…”

Section: Discussionmentioning

confidence: 99%

Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients

et al. 2016

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BackgroundThe POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) was reported to be associated with tumor progression and metastasis. The purpose of this study was to evaluate the prognostic value of Pit-1 in breast cancer patients.Material/MethodsThe relative expression levels of Pit-1 in breast cancer patients were detected by quantitative real-time PCR (qRT-PCR). Chi-square analysis was used to analyze the association between Pit-1 expression and clinical features. The Kaplan-Meier method was used to estimate the overall survival of the patients and Cox regression analysis was used to analyze the prognostic value of Pit-1.ResultsIncreased expression of Pit-1 was detected in the tumor tissues compared with the normal tissues (1.086 vs. 0.541) and the abnormal expression was associated with tumor size, clinical stage, tumor grade, and lymph node metastasis (P<0.05). High expression level of Pit-1 was significantly associated with poor overall survival of the patients (P=0.001) and Cox regression analysis indicated that Pit-1 might be a prognostic factor for breast cancer prognosis (HR=1.955, 95% CI=1.295–3.035, P=0.003).ConclusionsPit-1 may be a potential prognostic biomarker for breast cancer patients and it is associated with tumor progression.

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Decreased expression of SOX17 is associated with tumor progression and poor prognosis in breast cancer

Cited by 25 publications

References 36 publications

Overexpression of Keratin17 is Associated With Prognosis of Oral Cancer in the Chinese Population

Overexpression of Keratin17 is Associated With Prognosis of Oral Cancer in the Chinese Population

Overexpression of <em>HDAC9</em> is associated with poor prognosis and tumor progression of breast cancer in Chinese females

Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients

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