Decreased expression of the CHD5 gene and its clinicopathological significance in breast cancer: Correlation with aberrant DNA methylation

Song, Jinping; Liu, Simin; Han, Liang; Chen, Yangping; Wang, Yaqiu; Yu, Chundong; Hou, Lin

doi:10.3892/ol.2016.5147

Cited by 9 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CHD5 gene methylation has been associated with many diseases, so abnormal methylation through the downregulation of CHD5 may cause breast cancer development (Ma et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of smoking on methylation and semen parameters

Naeimi,

Mohseni Kouchesfehani,

Heidari

et al. 2024

Environ and Mol Mutagen

View full text Add to dashboard Cite

One type of epigenetic modification is genomic DNA methylation, which is induced by smoking, and both are associated with male infertility. In this study, the relationship between smoking and CHD5 gene methylation and semen parameters in infertile men was determined. After the MS‐PCR of blood in 224 samples, 103 infertile patients (62 smokers and 41 non‐smokers) and 121 fertile men, methylation level changes between groups and the effect of methylation and smoking on infertility and semen parameters in infertile men were determined. The results showed that there is a significant difference in the methylation status (MM, MU, UU) of the CHD5 gene between the patient and the control group, and this correlation also exists for the semen parameters (p < .001). The average semen parameters in smokers decreased significantly compared to non‐smokers and sperm concentration was (32.21 ± 5.27 vs. 55.27 ± 3.38), respectively. MM methylation status was higher in smokers (22.5%) compared to non‐smokers (14.6%). Smoking components affect the methylation pattern of CHD5 gene, and smokers had higher methylation levels and lower semen parameters than non‐smokers, which can be biomarkers for evaluating semen quality and infertility risk factors. Understanding the epigenetic effects of smoking on male infertility can be very useful for predicting negative consequences of smoking and providing therapeutic solutions.

show abstract

“…CHD5 gene methylation has been associated with many diseases, so abnormal methylation through the downregulation of CHD5 may cause breast cancer development (Ma et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of smoking on methylation and semen parameters

Naeimi,

Mohseni Kouchesfehani,

Heidari

et al. 2024

Environ and Mol Mutagen

View full text Add to dashboard Cite

show abstract

“…As one of nine members of the CHD family, CHD5 has been con rmed as the tumor suppressor in various malignant tumors. For example, Ma et al reported that the expression of CHD5 was signi cantly suppressed in breast cancer tissues and downregulation of CHD5 may contribute to the development and progression of breast cancer [22]. Liu et al showed that CHD5 mRNA was positively correlated with protein expression and CHD5 gene methylation is associated with clinical and pathological features of colorectal cancer patients [23].…”

Section: Discussionmentioning

confidence: 99%

CHD5 may be a promising novel bio-marker for the diagnosis of lung cancer patients

Yang

Zhong

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Chromodomain helicase DNA binding protein 5 (CHD5) is a new tumor suppressor gene in various types of cancer. And it is still not clear about the role of CHD5 in lung cancer. In this study, we aim to assess diagnostic value of CHD5 in patients with lung cancer. Methods CHD5 expression in 108 lung cancer serum samples and 65 healthy controls were determined by quantitative Real-Time PCR (qRT-PCR). A receiver operating characteristic (ROC) curve was established to analyze the effect of CHD5 in the diagnosis of lung cancer. Results The expression of CHD5 was significantly decreased in lung cancer samples compared with the healthy controls (P < 0.0001). Advanced TNM stage (P = 0.020), gender (P = 0.001) and smoking history (P = 0.000) were associated with the decreased CHD5 expression. Besides, the results of ROC analysis showed that the area under ROC curve (AUC) was 0.855 with a sensitivity of 87.1% and a specificity of 81.3%. Conclusions In conclusion, this study suggested that CHD5 expression is down-regulated in lung cancer. Furthermore, CHD5 expression could be a potential diagnosis bio-marker in lung cancer patients.

show abstract

“…CHD5, also known as DNA binding 5, is a member of the subclass of chromatin remodeling Swi/Snf proteins and is currently considered to be a tumor suppressor (73). The frequency of abnormal DNA methylation of the CHD5 gene promoter is inversely related to the prognosis of patients with cancer and has been observed in several malignancies (74)(75)(76)(77)(78). Despite the limited number of studies, CHD5 promoter methylation has been shown to be associated with OC, suggesting its potential clinical applications in OC metastasis, treatment and prognosis.…”

Section: Tumor Suppressor Genesmentioning

confidence: 99%

Current data and future perspectives on DNA methylation in ovarian cancer (Review)

Fu,

Deng,

Chen

et al. 2024

Int J Oncol

View full text Add to dashboard Cite

Ovarian cancer (OC) represents the most prevalent malignancy of the female reproductive system. Its distinguishing features include a high aggressiveness, substantial morbidity and mortality, and a lack of apparent symptoms, which collectively pose significant challenges for early detection. Given that aberrant DNA methylation events leading to altered gene expression are characteristic of numerous tumor types, there has been extensive research into epigenetic mechanisms, particularly DNA methylation, in human cancers. In the context of OC, DNA methylation is often associated with the regulation of critical genes, such as BRCA1/2 and Ras-association domain family 1A. Methylation modifications within the promoter regions of these genes not only contribute to the pathogenesis of OC, but also induce medication resistance and influence the prognosis of patients with OC. As such, a more in-depth understanding of DNA methylation underpinning carcinogenesis could potentially facilitate the development of more effective therapeutic approaches for this intricate disease. The present review focuses on classical tumor suppressor genes, oncogenes, signaling pathways and associated microRNAs in an aim to elucidate the influence of DNA methylation on the development and progression of OC. The advantages and limitations of employing DNA methylation in the diagnosis, treatment and prevention of OC are also discussed. On the whole, the present literature review indicates that the DNA methylation of specific genes could potentially serve as a prognostic biomarker for OC and a therapeutic target for personalized treatment strategies. Further investigations in this field may yield more efficacious diagnostic and therapeutic alternatives for patients with OC.

show abstract

Decreased expression of the CHD5 gene and its clinicopathological significance in breast cancer: Correlation with aberrant DNA methylation

Cited by 9 publications

References 28 publications

Effect of smoking on methylation and semen parameters

Effect of smoking on methylation and semen parameters

CHD5 may be a promising novel bio-marker for the diagnosis of lung cancer patients

Current data and future perspectives on DNA methylation in ovarian cancer (Review)

Contact Info

Product

Resources

About