Decreased Expression of TMEM173 Predicts Poor Prognosis in Patients with Hepatocellular Carcinoma

Yang, Baofeng; Liu, Fang; Jia, Qingan; Yu, Shiying

doi:10.1371/journal.pone.0165681

Cited by 46 publications

(44 citation statements)

References 22 publications

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“…STING was reported to be frequently inactivated in HPV-induced cancers (110) and in a large portion of melanomas (111). Low expression of STING in hepatocellular carcinoma (HCC) tissues was closely related to more advanced tumor stages and a worse outcome (112). Low RIG-I expression led to shorter survival and poor prognosis of patients with HCC (113) and gastric cancer (114).…”

Section: Perspectives Of Hippo-yap -Innate Immunity Crosstalk In Tumomentioning

confidence: 99%

The Crosstalk Between Hippo-YAP Pathway and Innate Immunity

et al. 2020

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Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of antiviral interferons and proinflammatory cytokines, which functions as the frontier of host defense against microbial pathogen invasion. Hippo-YAP pathway regulates cell proliferation, survival, differentiation and is involved in diverse life processes, including tissue homeostasis and tumor suppression. Emerging discoveries elucidated that the components of Hippo-YAP pathway, such as MST1/2, NDR1/2, and YAP/TAZ played crucial regulatory roles in innate immunity. Meanwhile the innate immune signaling also exhibited regulatory effect on Hippo-YAP pathway. As for the importance of these two pathways, it would be interesting to figure out the deeper biological implications of their interplays. This review focuses on the regulation between Hippo-YAP pathway and innate immune signaling. We also propose the possible contribution of these interplays to tumor development.

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Section: Perspectives Of Hippo-yap -Innate Immunity Crosstalk In Tumomentioning

confidence: 99%

The Crosstalk Between Hippo-YAP Pathway and Innate Immunity

et al. 2020

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show abstract

“…Clinical studies revealed that the expression of STING was significantly reduced in HCC tissues compared to the controls, and lower expression of STING was associated with a more advanced tumor stages and a worse survival ( 27 ) as well with poor prognosis for patients with gastric cancer ( 28 ). Collectively, these studies suggest that STING and RIG-I sensors may serve as tumor suppressors and have clinical values against certain types of tumors as prognostic/predictive biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies

2018

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The innate immune system provides the first line of defense against pathogen infection though also influences pathways involved in cancer immunosurveillance. The innate immune system relies on a limited set of germ line-encoded sensors termed pattern recognition receptors (PRRs), signaling proteins and immune response factors. Cytosolic receptors mediate recognition of danger damage-associated molecular patterns (DAMPs) signals. Once activated, these sensors trigger multiple signaling cascades, converging on the production of type I interferons and proinflammatory cytokines. Recent studies revealed that PRRs respond to nucleic acids (NA) released by dying, damaged, cancer cells, as danger DAMPs signals, and presence of signaling proteins across cancer types suggests that these signaling mechanisms may be involved in cancer biology. DAMPs play important roles in shaping adaptive immune responses through the activation of innate immune cells and immunological response to danger DAMPs signals is crucial for the host response to cancer and tumor rejection. Furthermore, PRRs mediate the response to NA in several vaccination strategies, including DNA immunization. As route of double-strand DNA intracellular entry, DNA immunization leads to expression of key components of cytosolic NA-sensing pathways. The involvement of NA-sensing mechanisms in the antitumor response makes these pathways attractive drug targets. Natural and synthetic agonists of NA-sensing pathways can trigger cell death in malignant cells, recruit immune cells, such as DCs, CD8+ T cells, and NK cells, into the tumor microenvironment and are being explored as promising adjuvants in cancer immunotherapies. In this minireview, we discuss how cGAS–STING and RIG-I–MAVS pathways have been targeted for cancer treatment in preclinical translational researches. In addition, we present a targeted selection of recent clinical trials employing agonists of cytosolic NA-sensing pathways showing how these pathways are currently being targeted for clinical application in oncology.

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“…Most genes showed remarkable features, which were highly upregulated in LFGC but down-regulated in HFGC ( Figure S14A-B, top panels), and showed negative association with FGC ( Figure S14A-B, bottom panels) in TIGER-LC. Furthermore, several genes expressed much higher in LFGC than those in HFGC (Figure S14C-D) have been reported to be involved in the development and progression of liver 1 2 cancer [29][30][31][32] . Also, we found that PDCD1LG2 (PD-L2), ligand for PD-1, was up-regulated in LFGC compared to HFGC indicative of the sensitivity to the immune-checkpoint inhibitor (ICI) 33 .…”

Section: (Supplementary Materials and Methods) Consistent With The Cmentioning

confidence: 99%

Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer

Kwon

Budhu

Woo

et al. 2019

Preprint

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Background: Chronic inflammation and chromosome aneuploidy are major traits of primary liver cancer (PLC), which represent the second most common cause of cancer related death worldwide. Increased cancer fitness and aggressiveness of PLC may be achieved by enhancing tumoral genomic complexity that alters tumor biology.Method: Here, we developed a scoring method, namely functional genomic complexity (FGC), to determine the degree of molecular heterogeneity among 580 liver tumors with diverse ethnicities and etiologies by assessing integrated genomic and transcriptomic data. Results:We found that tumors with higher FGC scores are associated with chromosome instability and TP53 mutations, and a worse prognosis, while tumors with lower FGC scores have elevated infiltrating lymphocytes and a better prognosis. These results indicate that FGC scores may serve as a surrogate to define genomic heterogeneity of PLC linked to chromosomal instability and evasion of immune surveillance. Conclusion:Our findings demonstrate an ability to define genomic heterogeneity and corresponding tumor biology of liver cancer based only on bulk genomic and transcriptomic data.Our data also provide a rationale for applying this approach to survey liver tumor immunity and to stratify patients for immune-based therapy.

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Decreased Expression of TMEM173 Predicts Poor Prognosis in Patients with Hepatocellular Carcinoma

Cited by 46 publications

References 22 publications

The Crosstalk Between Hippo-YAP Pathway and Innate Immunity

The Crosstalk Between Hippo-YAP Pathway and Innate Immunity

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies

Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer

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