Decreased fractional urinary calcium excretion and serum 1,25-dihydroxyvitamin D and IGF-I levels in preeclampsia

Halhali, Ali; Díaz, Lorenza; Avila, Euclides; Ariza, Ana Carolina; Garabédian, M; Larrea, Fernando

doi:10.1016/j.jsbmb.2006.12.055

Cited by 43 publications

(50 citation statements)

References 27 publications

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“…Renal function changes are seen in symptom free women in whom preeclampsia will eventually develop. Several researchers have reported that hypocalciuria was associated with preeclampsia and could be considered a risk factor for development of preeclampsia in pregnancy 1,2,3 . Rodriquez et al 4 evaluated the role of decreasing calcium creatinine ratio and microalbuminuria in prediction of preeclampsia as early as in 1988 and have concluded that these tests may be useful screening tools in prediction of preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Calcium-creatinine ratio and microalbuminuria in prediction of preeclampsia

Sheela

Beena

Mhaskar

2011

J Obstet Gynecol India

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Section: Introductionmentioning

confidence: 99%

Calcium-creatinine ratio and microalbuminuria in prediction of preeclampsia

Sheela

Beena

Mhaskar

2011

J Obstet Gynecol India

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“…17 Halhali et al studied preeclampsia and normotensive groups, and showed natriuria levels of 87 ± 31 and 90 ± 29 mEq/l, which were non-significant values. 18 Likewise, according to Selly et al, urine sodium excretion did not differ between groups (preeclampsia group with 124 ± 13 and normotensive group with 100 ± 8 mmol/24 hours).…”

Section: Severe Pe (N = 14)mentioning

confidence: 79%

“…[14][15][16][17][18] These authors suggested that urinary calcium excretion levels may serve as a diagnostic tool for differentiating between the various forms of hypertension in pregnancy. This might be explained by an increase in tubular calcium reabsorption, rather than a decrease in glomerular filtration, since similar creatinine clearance values were found among the groups.…”

Section: Severe Pe (N = 14)mentioning

confidence: 99%

Natriuria and calciuria levels in preeclampsia: a cross-sectional study

et al. 2013

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CONTEXT AND OBJECTIVE: Sodium excretion abnormalities in preeclampsia have been studied in relation to several factors. The objective of this study was to compare natriuria (mEq/24 h) and calciuria levels (mg/24 h) in preeclamptic patients. DESIGN AND SETTING: An analytical cross-sectional study with a control group was conducted in the obstetric center and the high-risk pregnancy outpatient clinic at a university hospital in southern Brazil, and in a primary healthcare unit in the same city, including pregnant women with mild preeclampsia, severe preeclampsia or chronic hypertension, and women with normal pregnancies (14 patients in each group). METHOD: Natriuria was measured using an ion-selective electrode in an automated clinical chemistry analyzer (Hitache 917, Roche). All the patients collected 24-hour urine, at home or at the hospital, for analysis of proteins, creatinine, calcium, sodium and uric acid. Quantitative variables with asymmetrical distribution were described using the median, minimum and maximum, and were compared using the Kruskal-Wallis test. The results were logarithmically transformed, with one-way analysis of variance (ANOVA) by ranks and then the post-hoc Tukey test, and were analyzed by means of the Spearman correlation and receiver operating characteristic (ROC) curve. The significance level used was 0.05. RESULTS: There were significant differences between the groups in comparing severe preeclampsia with chronic hypertension and severe preeclampsia with controls (P < 0.0001 for both measurements). CONCLUSION: Natriuria levels may be lower in preeclampsia when associated with calciuria. Natriuria assessment is an additional test for differential diagnosis of hypertensive diseases in pregnancy, but is a poor predictor when used alone.RESUMO CONTEXTO E OBJETIVO: Alterações na excreção de sódio têm sido estudadas na pré-eclâmpsia relacionadas a vários fatores. O objetivo deste estudo foi comparar natriúria (mEq/24 h) com os níveis de calciúria (mg/24 h) em pacientes pré-eclâmpticas. ESTUDO E LOCAL: Estudo transversal analítico com grupo controle foi realizado no Centro Obstétrico e no Ambulatório de Gestação de Alto Risco em um hospital universitário no sul do Brasil, e na Unidade Bá-sica de Saúde na mesma cidade, incluindo gestantes com pré-eclâmpsia leve e grave, hipertensão crônica e gestações normais, com 14 pacientes em cada grupo. MÉTODO: A natriuria foi dosada através da medida de íon eletrodo seletivo, utilizando analizadores automáticos de química clínica (Hitache 917 Roche). Todas as pacientes coletaram urina de 24 h, em casa ou no hospital, para análise de proteínas, creatinina, cálcio, ácido úrico e sódio. As variáveis quantitativas com distribuição assimétrica foram descritas por mediana, mínimo e máximo, e comparadas por teste Kruskal-Wallis. Os resultados foram transformados logaritmicamente, com ANOVA one-way por ranking e, posteriormente, teste post-hoc de Tukey, e foram analisados por médias de correlações de Spearman e curva ROC (receiver operating characterist...

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“…Since it has been suggested that IGF-1 affects renal Ca re-absorption in distal tubule (Halhali et al 2007), IGF-1 is designed to influence parameters in the model. For example, we can deduce that high IGF-1 results in high K M value, and consequently it delays the Ca re-absorption saturation point.…”

Section: Filtrationmentioning

confidence: 99%

“…The regulation of renal phosphate re-absorption has been suggested to be through the synthesis of de novo protein which transports phosphate (Caverzasio and Bonjour 1993). IGF-1 may affect renal Ca re-absorption in the distal tubule where transport is active and affected by hormonal systems (Halhali et al 2007). Therefore, we hypothesize that renal Ca re-absorption is altered by the effect of IGF-1 and regulates urine Ca excretion.…”

Section: Filtrationmentioning

confidence: 99%

A Theoretical Modeling for Suggesting Unique Mechanism of Adolescent Calcium Metabolism

Lee

Cho

Okos

2013

Journal of Biosystems Engineering

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Purpose: Modeling has been used for elucidating the mechanism of complex biosystems. In spite of importance and uniqueness of adolescent calcium (Ca) metabolism characterized by a threshold Ca intake, its regulatory mechanism has not been covered and even not proposed. Hence, this study aims at model-based proposing potential mechanisms regulating adolescent Ca metabolism. Methods: Two different hypothetic mechanisms were proposed. The main mechanism is conceived based on Ca-protein binding which induces renal Ca filtration, while additional mechanism assumed that active renal Ca re-absorption regulated Ca metabolism in adolescents. Mathematical models were developed to represent the proposed mechanism and simulated them whether they could produce adolescent Ca profiles in serum and urine. Results: Simulation showed that both mechanisms resulted in the unique behavior of Ca metabolism in adolescents. Based on the simulation insulin-like growth factor-1 (IGF-1) is suggested as a potential regulator because it is related to both growth, a remarkable characteristic of adolescence, and Ca metabolism including absorption and bone accretion. Then, descriptive modeling is employed to conceptualize the hypothesized mechanisms governing adolescent Ca metabolism. Conclusions: This study demonstrated that modeling is a powerful tool for elucidating an unknown mechanism by simulating potential regulatory mechanisms in adolescent Ca metabolism. It is expected that various analytic applications would be plausible in the study of biosystems, particularly with combination of experimental and modeling approaches.

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Decreased fractional urinary calcium excretion and serum 1,25-dihydroxyvitamin D and IGF-I levels in preeclampsia

Cited by 43 publications

References 27 publications

Calcium-creatinine ratio and microalbuminuria in prediction of preeclampsia

Calcium-creatinine ratio and microalbuminuria in prediction of preeclampsia

Natriuria and calciuria levels in preeclampsia: a cross-sectional study

A Theoretical Modeling for Suggesting Unique Mechanism of Adolescent Calcium Metabolism

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