Decreased glucose tolerance but normal blood glucose levels in the field in the caviomorph rodent Ctenomys talarum: The role of stress and physical activity

Vera, Federico; Zenuto, Roxana Rita; Antenucci, C. Daniel

doi:10.1016/j.cbpa.2008.06.030

Cited by 30 publications

(64 citation statements)

References 35 publications

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“…The capture and transport to the laboratory constitutes a very strong stressor for tuco-tucos, causing a marked increase in the neutrophyl:lymphocyte ratio (N:L). After 10 days in captivity, N:L ratios decrease to values similar to those monitored in the field (Vera et al, 2008), and cortisol levels remain similar to field values (F. Vera, R.R.Z. and C.D.A., unpublished).…”

Section: Immunisationsupporting

confidence: 70%

“…eosinophils). These parameters may reflect an increase in stress levels associated with captivity (see also Vera et al, 2008) and a concomitant immunosuppression (but see Davis et al, 2008). Hence, the ability of tuco-tucos to mount an immune response against SRBC could have been underestimated in this study.…”

Section: Implications For Interspecific Immunological Variationmentioning

confidence: 94%

“…Animals remained in captivity for 10 days before receiving the first injection because a previous study showed that this is the necessary time lapse for animals to acclimatise to captivity conditions and, hence, lower their stress levels (Vera et al, 2008). The capture and transport to the laboratory constitutes a very strong stressor for tuco-tucos, causing a marked increase in the neutrophyl:lymphocyte ratio (N:L).…”

Section: Immunisationmentioning

confidence: 99%

“…Further, because different types of leukocytes perform different functions, the relative abundance of leukocyte types can be used to draw inferences about the roles of acute vs chronic immune challenges in shaping the immune response (Nunn et al, 2000). Additionally, N:L is a known chronic stress indicator (Davis et al, 2008), which could serve to monitor the animals' stress status while in captivity (see Vera et al, 2008). Leukocyte abundance and diversity was quantified following standard protocols (Voigt, 2000).…”

Section: Determination Of Leukocyte Profilementioning

confidence: 99%

“…The cells were counted only across the entire monolayer area of the slide ['wandering technique' (Voigt, 2000)]. All cell types were identified according to the characteristics of their morphology described in standard laboratory mammals (Voigt, 2000) and previous data for the species (Vera et al, 2008): lymphocyte, neutrophil, eosinophil, basophil and monocyte. Leukocyte counts were obtained by recording the number and kind of each cell type until a cumulative number of 200 cells was reached; then, the relative count for each cell type over the total number of leukocytes and the N:Lratio were calculated.…”

Section: Determination Of Leukocyte Profilementioning

confidence: 99%

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Mounting a specific immune response increases energy expenditure of the subterranean rodentCtenomys talarum(tuco-tuco): implications for intraspecific and interspecific variation in immunological traits

Cutrera

Zenuto

Luna

et al. 2010

Journal of Experimental Biology

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SUMMARYIt was recently hypothesised that specific induced defences, which require substantial time and resources and are mostly beneficial against repeated infections, are more likely to be favoured in 'slow-living-pace' species. Therefore, understanding how different types of immune defences might vary with life history requires knowledge of the costs and benefits of defence components. Studies that have explored the energetic costs of immunity in vertebrates have done so with a focus primarily on birds and less so on mammals, particularly surface-dwelling rodents. In this study, we evaluated whether an experimental induction of the immune system with a non-pathogenic antigen elevates the energetic expenditure of a subterranean rodent: Ctenomys talarum (tuco-tucos). In both seasons studied, a significant increase in oxygen consumption was verified in immune-

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Section: Immunisationsupporting

confidence: 70%

Section: Implications For Interspecific Immunological Variationmentioning

confidence: 94%

Section: Immunisationmentioning

confidence: 99%

Section: Determination Of Leukocyte Profilementioning

confidence: 99%

Section: Determination Of Leukocyte Profilementioning

confidence: 99%

See 3 more Smart Citations

Mounting a specific immune response increases energy expenditure of the subterranean rodentCtenomys talarum(tuco-tuco): implications for intraspecific and interspecific variation in immunological traits

Cutrera

Zenuto

Luna

et al. 2010

Journal of Experimental Biology

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Prenatal predatory stress in a wild species of subterranean rodent: Do ecological stressors always have a negative effect on the offspring?

Brachetta

Schleich

Cutrera

et al. 2018

Developmental Psychobiology

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In pregnant females, a failed predatory event not only induces individual responses but also represents a significant change in the developmental environment of the offspring, which may lead to modifications in their phenotype that may persist at different stages of life. We evaluate whether prenatal exposure to predatory cues affects anxiety behavior, behavioral response to predator cues, stress response to immobilization, and immune response to sheep red blood cells (SRBC) and phytohemagglutinin (PHA) in juveniles of the subterranean rodent Ctenomys talarum. We found that prenatal predator stress (PPS) (1) increased juvenile anxiety-like behaviors and the appearance of antipredator behaviors, (2) did not affect the response of offspring to predatory stressors, and (3) did not influence the physiological response of juveniles to stressors (immobilization) nor the immunological responses to SRBC and PHA challenges. This work shows the influence of PPS on the development of behavioral responses in the offspring, whom displayed a state of anxiety and behavioral changes associated with decreased locomotor activity and avoidance behaviors. Thus, these individuals prenatally exposed to predatory cues show behavioral adaptations that may contribute to avoid predators in the adult life.

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Differential Responses of Cortisol and Corticosterone to Adrenocorticotropic Hormone (ACTH) in a Subterranean Rodent (Ctenomys talarum)

Vera

Zenuto²,

Antenucci³

2012

J. Exp. Zool.

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We aimed to evaluate the responses of cortisol, corticosterone, and blood glucose to adrenocorticotropic hormone (ACTH) in males and females of the subterranean rodent Ctenomys talarum and addressed interannual variations in the plasma levels of both hormones. The most important results indicate that: (1) cortisol positively responds to the ACTH signal but corticosterone does not, even though corticosterone levels were higher than cortisol concentrations, (2) plasma corticosterone concentrations in free-living animals were 20 times higher compared to values reported for the same population during previous annual periods and, as cortisol levels were similar, this resulted in much lower cortisol/corticosterone ratios, (3) cortisol and corticosterone differentiated in their relative proportions in plasma in free-living males and females. These results indicate that cortisol and corticosterone are differentially regulated in our study species and emphasize that a remarkable temporal variation in the relative proportions of these hormones may occur in natural populations. Therefore, the conclusions regarding the presence of cortisol and corticosterone in plasma of wild animals may differ substantially depending on the moment when the study is conducted. Recent data indicate that cortisol and corticosterone are not interchangeable hormones in species of free-living vertebrates. We suggest that, in addition to the classical roles of glucocorticoids (GCs), it is crucial that other physiological functions be kept in mind when interpreting GC data from wild species.

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Decreased glucose tolerance but normal blood glucose levels in the field in the caviomorph rodent Ctenomys talarum: The role of stress and physical activity

Cited by 30 publications

References 35 publications

Mounting a specific immune response increases energy expenditure of the subterranean rodentCtenomys talarum(tuco-tuco): implications for intraspecific and interspecific variation in immunological traits

Mounting a specific immune response increases energy expenditure of the subterranean rodentCtenomys talarum(tuco-tuco): implications for intraspecific and interspecific variation in immunological traits

Prenatal predatory stress in a wild species of subterranean rodent: Do ecological stressors always have a negative effect on the offspring?

Differential Responses of Cortisol and Corticosterone to Adrenocorticotropic Hormone (ACTH) in a Subterranean Rodent (Ctenomys talarum)

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