Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment

Katzorke, Andrea; Zeller, Julia; Müller, Laurent; Lauer, Martin; Polak, Thomas; Deckert, Jürgen; Herrmann, Martin J.

doi:10.1016/j.pscychresns.2018.02.003

Cited by 41 publications

(45 citation statements)

References 60 publications

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“…Of the 46 included articles, 13 included a mix of younger and older participants (Heilbronner and Münte, 2013;Ohsugi et al, 2013;Beurskens et al, 2014;Müller et al, 2014;Oboshi et al, 2014;Hernandez et al, 2016;Bierre et al, 2017;Mirelman et al, 2017;Rosso et al, 2017;Hawkins et al, 2018) whereas 29 included only older adults (Doi et al, 2013;Heinzel et al, 2013Heinzel et al, , 2015Niu et al, 2013;Clark et al, 2014;Vermeij et al, 2014;Dupuy et al, 2015;Holtzer et al, 2015Holtzer et al, , 2016Holtzer et al, , 2017aHoltzer et al, ,b, 2018aLaguë-Beauvais et al, 2015;Al-Yahya et al, 2016;Maidan et al, 2016Maidan et al, , 2017Mahoney et al, 2016;Nieuwhof et al, 2016;Osofundiya et al, 2016;Takeuchi et al, 2016;Uemura et al, 2016;Yeung et al, 2016a,b;Chen et al, 2017;Huppert et al, 2017;Verghese et al, 2017;Yap et al, 2017;Halliday et al, 2018;Katzorke et al, 2018;Lucas et al, 2018;Mori et al, 2018;Thumm et al, 2018). Moreover, 26 studies included only cognitively normal participants…”

Section: General Descriptionmentioning

confidence: 99%

“…Most source populations were community-dwelling but two studies included older adults living in nursing home (Osofundiya et al, 2016;Huppert et al, 2017). Ten studies did not describe the participant setting (Niu et al, 2013;Oboshi et al, 2014;Al-Yahya et al, 2016;Uemura et al, 2016;Maidan et al, 2017;Mirelman et al, 2017;Rosso et al, 2017;Katzorke et al, 2018;Mori et al, 2018;Thumm et al, 2018).…”

Section: General Descriptionmentioning

confidence: 99%

“…The majority, 29 studies, used O 2 Hb to assess brain activation while nine studies (Heilbronner and Münte, 2013;Beurskens et al, 2014;Müller et al, 2014;Al-Yahya et al, 2016;Hyodo et al, 2016;Nieuwhof et al, 2016;Rosso et al, 2017;Halliday et al, 2018;Katzorke et al, 2018) used both O 2 Hb and HHb and one used only Total Hb (Huppert et al, 2017). Two studies calculated the Total Oxygenation Index (O 2 Hb/Total Hb x 100) in order to assess brain hemodynamics (Clark et al, 2014;Bierre et al, 2017).…”

Section: General Descriptionmentioning

confidence: 99%

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Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review

Udina

Avtzi

Durdurán

et al. 2020

Front. Aging Neurosci.

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The integrity of the frontal areas of the brain, specifically the prefrontal cortex, are critical to preserve cognition and mobility in late life. Prefrontal cortex regions are involved in executive functions and gait control and have been related to the performance of dual-tasks. Dual-task performance assessment may help identify older adults at risk of negative health outcomes. As an alternative to neuroimaging techniques that do not allow assessment during actual motion, functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive technique that can assess neural activation through the measurement of cortical oxygenated and deoxygenated hemoglobin levels, while the person is performing a motor task in a natural environment as well as during cognitive tasks. The aim of this review was to describe the use of fNIRS to study frontal lobe hemodynamics during cognitive, motor and dual-tasks in older adults. From the 46 included publications, 20 studies used only cognitive tasks, three studies used motor tasks and 23 used dual-tasks. Our findings suggest that fNIRS detects changes in frontal activation in older adults (cognitively healthy and mild cognitive impairment), especially while performing cognitive and dual-tasks. In both the comparison between older and younger adults, and in people with different neurological conditions, compared to healthier controls, the prefrontal cortex seems to experience a higher activation, which could be interpreted in the context of proposed neural inefficiency and limited capacity models. Further research is needed to establish standardized fNIRS protocols, study the cerebral hemodynamic in different neurological and systemic conditions that might influence cortical activation and explore its role in predicting incident health outcomes such as dementia.

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Section: General Descriptionmentioning

confidence: 99%

Section: General Descriptionmentioning

confidence: 99%

Section: General Descriptionmentioning

confidence: 99%

See 1 more Smart Citation

Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review

Udina

Avtzi

Durdurán

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

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“…To date, functional near-infrared spectroscopy (fNIRS) research related to dementia and verbal fluency has indicated that there are decreased hemodynamic responses in the inferior frontotemporal regions in the MCI population (Katzorke et al, 2018) and in the prefrontal and parietal areas in individuals with AD (Arai et al, 2006;Metzger et al, 2016) compared to healthy older adults, revealing the effects of neuropathological changes on brain activation patterns during verbal fluency tasks in these populations. The depth resolution of fNIRS, however, has limited the researchers to investigating relatively lateral brain regions that are more adjacent to the skull (Obrig, 2014); there has been little consideration of deeper brain structures (e.g., subcortical, medial, and insular areas as well as even some cortices), even though fluency tasks have been shown to engage these areas (Beber and Chaves, 2014;Li et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Paek

Murray

Newman

2020

Front. Aging Neurosci.

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Currently there are ∼6 million Americans who are affected by dementia. Verbal fluency tasks have been commonly and frequently utilized to document the disease progression in many forms of dementia. Verb fluency has been found to display substantial potential to detect and monitor the cognitive declines of individuals with dementia who have fronto-striatal involvement. The neural substrates underlying verb fluency task performance, however, have remained unclear so far, especially in individuals with dementia. Therefore, in the current study, brain activation patterns of seven individuals with dementia and nine healthy older adults were investigated using functional MRI. The participants performed in the scanner an overt, subject-paced verb fluency task, representative of fluency tasks used in clinical settings. The brain activation patterns during the verb fluency task were compared between the two groups, and a correlational analysis was conducted to determine the neural correlates of verb fluency performance. The results suggest that compared to healthy older adults, individuals with dementia demonstrated poorer verb fluency performance and showed higher activation in specific neural regions, such as the bilateral frontal lobe. In addition, the correlational analysis revealed that poorer verb fluency performance lead to increased activation in certain cortical and subcortical areas, including left hippocampus and right supramarginal gyrus. The current findings are consistent with previous neurophysiological findings related to semantic (noun) fluency performance in older adults and individuals with dementia and add to the empirical evidence that supports the role of the frontal lobe and hippocampus in verb retrieval and search. Declines in verb fluency performance cannot only be used as a cognitive marker, but also represent neuropathological changes due to the neurodegenerative disease.

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“…224 The HbO response was reduced in the inferior frontotemporal cortex in MCI patients compared to that in healthy persons. 225…”

Section: Verbal°uency Taskmentioning

confidence: 99%

Application of functional near-infrared spectroscopy in the healthcare industry: A review

Hong

Yaqub

2019

J. Innov. Opt. Health Sci.

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Functional near-infrared spectroscopy (fNIRS), a growing neuroimaging modality, has been utilized over the past few decades to understand the neuronal behavior in the brain. The technique has been used to assess the brain hemodynamics of impaired cohorts as well as able-bodied. Neuroimaging is a critical technique for patients with impaired cognitive or motor behaviors. The portable nature of the fNIRS system is suitable for frequent monitoring of the patients who exhibit impaired brain activity. This study comprehensively reviews brain-impaired patients: The studies involving patient populations and the diseases discussed in more than 10 works are included. Eleven diseases examined in this paper include autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, depressive disorders, anxiety and panic disorder, schizophrenia, mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease, stroke, and traumatic brain injury. For each disease, the tasks used for examination, fNIRS variables, and significant findings on the impairment are discussed. The channel configurations and the regions of interest are also outlined. Detecting the occurrence of symptoms at an earlier stage is vital for better rehabilitation and faster recovery. This paper illustrates the usability of fNIRS for early detection of impairment and the usefulness in monitoring the rehabilitation process. Finally, the limitations of the current fNIRS systems (i.e., nonexistence of a standard method and the lack of well-established features for classification) and future research directions are discussed. The authors hope that the findings in this paper would lead to advanced breakthrough discoveries in the fNIRS field in the future.

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Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment

Cited by 41 publications

References 60 publications

Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review

Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Application of functional near-infrared spectroscopy in the healthcare industry: A review

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