2015
DOI: 10.2174/2211556004666150918194108
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Decreased Incidence of Readmissions in First Episode Psychosis in Treatment with Long - Acting Injectable Antipsychotics

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Cited by 6 publications
(11 citation statements)
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“…In this naturalistic study we established that the number of hospitalizations and the total number of bed days after 1 year of ALAI treatment decreased significantly, with the average number of bed days dropping by 7 days. These findings of superior efficacy of ALAI compared to oral antipsychotics are in line with the data from several earlier studies of other second-generation LAI's in FES and ROS (Kishi, Oya, & Iwata, 2016;Toll Privat et al, 2015). However, not all of the earlier reports confirm the better efficacy of LAI's over oral antipsychotics (Medrano et al, 2018).…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…In this naturalistic study we established that the number of hospitalizations and the total number of bed days after 1 year of ALAI treatment decreased significantly, with the average number of bed days dropping by 7 days. These findings of superior efficacy of ALAI compared to oral antipsychotics are in line with the data from several earlier studies of other second-generation LAI's in FES and ROS (Kishi, Oya, & Iwata, 2016;Toll Privat et al, 2015). However, not all of the earlier reports confirm the better efficacy of LAI's over oral antipsychotics (Medrano et al, 2018).…”
Section: Discussionsupporting
confidence: 82%
“…Regarding the use of other LAI's in first episode psychosis, a study by Medrano and associates included several LAI's (although, not ALAI), and reported symptomatic and functional improvement, however to a lesser extent than with oral antipsychotics (Medrano, Abdel-Baki, Stip, & Potvin, 2018). Those results are in contrast with improvement reported by other authors and meta analyses (Kishi, Oya, Iwata, 2016;Schreiner et al, 2015;Toll Privat, Baquero, Santacana, & Sola, 2015).…”
contrasting
confidence: 95%
“…Study by Medrano and associates included PP-1M, among seven other LAI’s, and reported symptomatic and functional improvement in FES, however to a lesser extent than oral antipsychotics [ 18 ]. Those results are in contrast with improvement reported by other authors and meta-analyses [ 19 , 20 ]. Furthermore, in one identified study focusing specifically on PP-1M in recent diagnosed schizophrenia authors reported significantly lower rates of relapse, as well as clinical and functional improvement [ 21 ].…”
Section: Introductioncontrasting
confidence: 99%
“…Although similar results with PP-1M have been reported on several occasions in patients with schizophrenia, there is only a small number of available studies that focused on first episode and early schizo-phrenia. Two studies on patients with first episode schizophrenia, although not on PP-1M homogenous samples, also reported PP-1M outperforming oral antipsychotics [ 19 , 20 ], as well as a study on a PP-1M homogenous sample in recent diagnosed schizophrenia (up to five years after first diagnosis) [ 21 ]. On the other hand, reported results are in contrast to some of the earlier reports in which LAI’s (not only PP-1M) did not outperform oral antipsychotics in treating patients with first episode psychosis [ 18 ].…”
Section: Discussionmentioning
confidence: 99%
“…After excluding duplicates, 250 articles remained. A total of 15 studies (Abdel‐Baki et al, 2019; Alphs et al, 2018; Barrio et al, 2013; Emsley et al, 2008; Ibach & Schreiner, 2008; Kim et al, 2008; Malla et al, 2016; Privat et al, 2015; Rifkin et al, 1977; Schreiner et al, 2015; Segarra et al, 2010; Subotnik et al, 2015; Taipale et al, 2018; Titus‐Lay et al, 2018; Weiden et al, 2012) (n = 10 584) comparing LAIs with OAPs were selected to be included in the present meta‐analysis. Table 1 summarizes the characteristics of the included studies.…”
Section: Resultsmentioning
confidence: 99%