Decreased incidence of reticulum cell sarcoma in whole body irradiated and bone marrow shielded mice

Covelli,; Metalli, P.; Bassani, B.

doi:10.1038/bjc.1975.73

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…She completed six courses of MOPP therapy with no complication and with resolution of all signs and symptoms and remained in excellent health until she noticed a mass in the right inguinal area in June 1974. She denied fever or night sweats, but had lost 12 pounds. Hematocrit was 4696, WBC 72OOicu mm, and platelets 300,OOO/cu mm.…”

Section: Casementioning

confidence: 99%

The development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease

Kim

Bedetti

Boggs

1980

Cancer

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Three patients developed non-Hodgkin's lymphoma (NHL) 3-6 years after treatment for Hodgkin's disease (HD). In no instance was there evidence of recurrence of HD following the initial chemotherapy or radiotherapy. None of these patients had received both radiation therapy and chemotherapy. The histologic classification of the developing of the developing NHL for the three patients was (1) diffuse, poorly differentiated lymphocytic, (2) nodular histocytic, and (3) nodular, poorly differentiated lymphocytic. In no instance was there any histologic similarity to the original HD. Perhaps most important with respect to histology was the easily demonstrable presence of Reed-Sternberg cells at the time of original diagnosis and their absence with onset of NHL. All patients responded well to conventional chemotherapy for NHL and are alive at 23+, 37+, and 65+ months after that secondary diagnosis. This report, when coupled with at least ten other such reported patients, suggests that NHL may be a relatively uncommon but significant complication of therapy for HD and must be distinguished for recurrence of HD.

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Section: Casementioning

confidence: 99%

The development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease

Kim

Bedetti

Boggs

1980

Cancer

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Experimental Radiation Carcinogenesis

Silini

1986

Radiation Carcinogenesis and DNA Alterations

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Late Somatic Effects in Syngeneic Radiation Chimaeras

Metalli¹,

Silini²,

Covelli³

et al. 1976

International Journal of Radiation Biology and Related Studies

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Lethally-irradiated mice received a graft of bone-marrow cells obtained from intact syngeneic animals or from donors pre-irradiated with 200 or 400 rad. The numbers of haemopoietic cells injected were sufficient to give a high percentage of recipients which survived short-term bone-marrow failure. Epidemiological and pathological observations on long-term surviving animals showed an increased incidence of nephrosclerosis and of systemic or solid tumours following different relationships with the radiation dose given to the cells. These data are discussed within the framework of an experimental model system which might allow estimates of incidence of some neoplastic diseases according to cellular hypotheses of tumour induction.

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Decreased incidence of reticulum cell sarcoma in whole body irradiated and bone marrow shielded mice

Cited by 4 publications

References 3 publications

The development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease

The development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease

Experimental Radiation Carcinogenesis

Late Somatic Effects in Syngeneic Radiation Chimaeras

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