Decreased initial pupil size and shortened constriction latency due to negative mood states and mental fatigue in clinical subacute pain models

Hatsukawa, Hiroatsu; Ishikawa, Masaaki

doi:10.1016/j.physbeh.2022.113850

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…On the other hand, pupil size reflects mental activity through the mediation of the autonomic nervous system (Ando et al, 2002). Mental fatigue can be associated with pupil constriction (Hatsukawa & Ishikawa, 2022). Pupil miosis under different illuminance was found in this study, it may imply the fatigue state of mental activity after use of AR glasses.…”

Section: Discussionmentioning

confidence: 99%

Change in three‐dimensional choroidal vessel network after AR device assisted 1‐hour visual task in 2D/3D mode in young healthy subjects

Liu

et al. 2023

Acta Ophthalmologica

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PurposeThe purpose of the study was to investigate the changes of choroidal blood perfusion in different layers and quadrants and its possible related factors after 1 h visual task by augmented reality (AR) device in two‐dimensional (2D) and three‐dimensional (3D) mode, respectively.MethodsThirty healthy subjects aged 22–37 years watched the same video source in 2D and 3D mode separately using AR glasses for 1 h with a one‐week interval. Swept‐source optical coherence tomography angiography (SS‐OCTA) was performed before and immediately after watching to acquire choroidal thickness (ChT), three‐dimensional choroidal vascularity index (CVI) of large‐ and middle‐sized choroidal vessels and choriocapillaris flow voids (FV%) at macular and peripapillary area. Near point of accommodation (NPA) and accommodative facility (AF) were examined to evaluate the accommodative ability. Pupil diameters by infrared‐automated pupillometer under scotopic, mesopic and photopic condition were also obtained.ResultsCompared with pre‐visual task, the subfoveal CVI decreased from 0.406 ± 0.097 to 0.360 ± 0.102 after 2D watching (p < 0.001) and to 0.368 ± 0.102 after 3D watching (p = 0.002). Pupil sizes under different illuminance conditions became smaller after both 2D and 3D watching (all p < 0.001). AF increased after both 2D and 3D watching (both p < 0.05). NPA receded in post‐3D watching (p = 0.017) while a not significant tendency was observed in post‐2D.ConclusionA reduction in subfoveal choroidal blood flow accompanied with pupil constriction was observed immediately after 1 h visual task using AR glasses in 2D and 3D mode. Accommodative facility improved after 2D and 3D watching with AR glasses, whereas decrease in the maximum accommodation power was only found in 3D mode.

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Section: Discussionmentioning

confidence: 99%

Change in three‐dimensional choroidal vessel network after AR device assisted 1‐hour visual task in 2D/3D mode in young healthy subjects

Liu

et al. 2023

Acta Ophthalmologica

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“…This is because pain stimulation can lead to pupil dilation through increased sympathetic outflow to the pupil from the LC 12 , 14 . To explain the finding, two studies used POMS, and then explained how the decreased INIT could occur even during the experience of pain from the point of view of psychological states 31 , 32 : The increase of subjective pain intensity caused the worsened states of Fatigue/Vigor, which were associated with decreased INIT. In POMS, Fatigue and Vigor can be valid indicators of mental fatigue 33 .…”

Section: Discussionmentioning

confidence: 99%

“…The T&T olfactometer showed average scores (for recognition of five odorants) of < 1.1, and the nasal endoscopy showed no anatomical obstructions. The median age (IQR), male ratio and Brinkman index were 29 (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40), 50% and 0 (0-16), respectively.…”

Section: Methodsmentioning

confidence: 99%

Psychological states affecting initial pupil size changes after olfactory stimulation in healthy participants

Hatsukawa,

Ishikawa

2023

Sci Rep

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Odor perception affects physiological and psychological states. Pupillary light reflex (PLR) parameters can be affected by olfactory stimulation and psychological states, although it remains unclear whether the olfactory stimulation-induced psychological changes can associate with PLR parameter changes. This study aimed to investigate effects of olfactory stimulation-induced psychological changes on PLR parameter changes with repeated measurements. We collected data on six mood subscales of the profile of mood states, and on five PLR parameter measurements from 28 healthy participants. Participants underwent a 10-min olfactory stimulation on different days with six odorants available with the T&T olfactometer. As obtained data were clustered, we used linear mixed-effects models for statistical analyses. The olfactory stimulation using the no-odor liquid did not affect mood states and the initial pupil size (INIT). The sweat odorant worsened all mood subscales including fatigue–inertia (Fatigue)/Vigor–Activity (Vigor), and decreased INIT compared to the no-odor liquid. When comparing INIT responses related to changes in mood subscales between the no-odor liquid and the sweat odorant, worsened states of Fatigue/Vigor were associated with decreased INIT in the sweat odorant. Fatigue/Vigor can be used as mental fatigue indicators. Thus, mental fatigue can be associated with decreased INIT in the olfactory stimulation.

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The Impact of Blue Light and Dark UI on Eye Fatigue and Cognitive Workload

Mahmood,

Omeroglu,

Abbasi

et al. 2023

Lecture Notes in Computer Science

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Decreased initial pupil size and shortened constriction latency due to negative mood states and mental fatigue in clinical subacute pain models

Cited by 5 publications

References 40 publications

Change in three‐dimensional choroidal vessel network after AR device assisted 1‐hour visual task in 2D/3D mode in young healthy subjects

Change in three‐dimensional choroidal vessel network after AR device assisted 1‐hour visual task in 2D/3D mode in young healthy subjects

Psychological states affecting initial pupil size changes after olfactory stimulation in healthy participants

The Impact of Blue Light and Dark UI on Eye Fatigue and Cognitive Workload

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