Decreased interleukin-10 serum levels in first-episode drug-naïve schizophrenia: Relationship to psychopathology

Xiu, Mei Hong; Yang, Gui Gang; Tan, Yun Long; Chen, Da Chun; Tan, Shu Ping; Wang, Zhi Ren; Yang, Fu De; Okusaga, Olaoluwa; Soares, Jair C.; Zhang, Xiang Yang

doi:10.1016/j.schres.2014.03.024

Cited by 65 publications

(46 citation statements)

References 59 publications

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“…While De Witte et al, (9) documented an increase in serum level of IL10 in schizophrenic patients as compared to control. In contrary some other studies reported a significantly lower serum levels of IL10 in schizophrenic patients as compared to control (24) . In the current study, results of the serum neuregulin 1, dictated significantly higher mean serum NRG1 in Schizophrenic group (34.1 ng/ml) when compared to both control groups (mean 16 and 15.8 ng/ml) in general population and relatives group respectively P<0.001).However other studies Wang et al, (25) and Shibuya et al, (26) reported in contrast, a lower level of immunoreactivity measurement of serum neuregulin 1 in schizophrenic patients as compared to control.…”

Section: Discussioncontrasting

confidence: 63%

Assessment the Serum Level of IL6, IL10 versus Neuregulin 1 among Schizophrenic Patients in Iraq

Khadhim¹

2017

jmscr

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Section: Discussioncontrasting

confidence: 63%

Assessment the Serum Level of IL6, IL10 versus Neuregulin 1 among Schizophrenic Patients in Iraq

Khadhim¹

2017

jmscr

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“…31 In addition, some recent studies show that patients with schizophrenia have a decrease in IL-10 level, which serves as an anti-inflammatory cytokine. 57 In support of this relationship, VEGF levels and proinflammatory cytokine IL-6 mRNA levels were significantly positively correlated in patients with schizophrenia, but not in Abbreviations: ANCOVA, analysis of covariance; HC, healthy control; PFC, prefrontal cortex; SC, schizophrenia. ANCOVA analyses of total prefrontal brain regions between healthy controls and patients with age and sex as covariates.…”

Section: Discussionmentioning

confidence: 94%

Association of serum VEGF levels with prefrontal cortex volume in schizophrenia

et al. 2015

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A large body of evidence indicates alterations in brain regional cellular energy metabolism and blood flow in schizophrenia. Among the different molecules regulating blood flow, vascular endothelial growth factor (VEGF) is generally accepted as the major factor involved in the process of angiogenesis. In the present study, we examined whether peripheral VEGF levels correlate with changes in the prefrontal cortex (PFC) volume in patients with schizophrenia and in healthy controls. Whole-blood samples were obtained from 96 people with schizophrenia or schizoaffective disorder and 83 healthy controls. Serum VEGF protein levels were analyzed by enzyme-linked immunosorbent assay, whereas quantitative PCR was performed to measure interleukin-6 (IL-6, a pro-inflammatory marker implicated in schizophrenia) mRNA levels in the blood samples. Structural magnetic resonance imaging scans were obtained using a 3T Achieva scanner on a subset of 59 people with schizophrenia or schizoaffective disorder and 65 healthy controls, and prefrontal volumes were obtained using FreeSurfer software. As compared with healthy controls, individuals with schizophrenia had a significant increase in log-transformed mean serum VEGF levels (t(177)=2.9, P=0.005). A significant inverse correlation (r=-0.40, P=0.002) between serum VEGF and total frontal pole volume was found in patients with schizophrenia/schizoaffective disorder. Moreover, we observed a significant positive association (r=0.24, P=0.03) between serum VEGF and IL-6 mRNA levels in patients with schizophrenia. These findings suggest an association between serum VEGF and inflammation, and that serum VEGF levels are related to structural abnormalities in the PFC of people with schizophrenia.

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“…It is hypothesized that schizophrenia would be associated with an imbalance in inflammatory cytokines, leading to a decrease in T H 1 and an increase in T H 2 cytokine secretion. 11 Hence, T H 2-type cytokines can contribute to dampen the immune and inflammatory responses, being potential anti-inflammatory mediators, 38 which determine immune regulation and the balance between inflammatory and anti-inflammatory responses. 11 Interestingly, these abnormalities are particularly prominent in treatment-resistant schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Effects of Electroconvulsive Therapy on Some Inflammatory Factors in Patients With Treatment-Resistant Schizophrenia

Kartalcı¹,

Karabulut²,

Erbay³

et al. 2016

J ECT

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Decreased interleukin-10 serum levels in first-episode drug-naïve schizophrenia: Relationship to psychopathology

Cited by 65 publications

References 59 publications

Assessment the Serum Level of IL6, IL10 versus Neuregulin 1 among Schizophrenic Patients in Iraq

Assessment the Serum Level of IL6, IL10 versus Neuregulin 1 among Schizophrenic Patients in Iraq

Association of serum VEGF levels with prefrontal cortex volume in schizophrenia

Effects of Electroconvulsive Therapy on Some Inflammatory Factors in Patients With Treatment-Resistant Schizophrenia

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