Decreased intracellular [Ca<sup>2+</sup>] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis

Wang, Mengmeng; Liang, Hao; Guo, Feng; Zhong, B.; Zhong, Xiaomei; Yuan, Jing; Hao, Yi-Fei; Zhao, Shuang; Sun, Xiaohong; Lei, Ming; Jiao, Guangyu

doi:10.1002/mus.25554

Cited by 4 publications

(1 citation statement)

References 42 publications

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“…Sepsis-induced diaphragmatic dysfunction includes the two aspects of decreased diaphragm contractility and diaphragm atrophy 2 . We found that contractile dysfunction was earlier than diaphragmatic atrophy in septic patients of our study, which had confirmed by basic and clinical studies 16 , 27 . With the aggravation of infection severity, we found a further decrease in the diaphragmatic contractile function by ultrasound, including parameters of TF, E QB /E DB, velocity in deep breathing and AUDMC.…”

Section: Discussionsupporting

confidence: 88%

Quantification of diaphragmatic dynamic dysfunction in septic patients by bedside ultrasound

Chen

Liu

Han

et al. 2022

Sci Rep

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Although diaphragmatic dysfunction is an important indicator of severity of illness and poor prognosis in ICU patients, there is no convenient and practical method to monitor diaphragmatic function. This study was designed to analyze diaphragmatic dynamic dysfunction by bedside ultrasound in septic patients and provide quantitative evidence to assess diaphragm function systematically. This prospective observational study was conducted from October 2019 to January 2021 in the Department of Respiratory and Critical Care Medicine. 74 patients suffered from sepsis were recruited and divided into two groups, sepsis group 1 (2 ≤ SOFA ≤ 5, n = 41) and sepsis group 2 (SOFA > 5, n = 33). 107 healthy volunteers were randomly recruited as the control group. In all participants, the diaphragmatic thickness and excursion were measured directly and the dynamic parameters including thickening fraction (TF), EQB/EDB, Contractile velocity, and area under diaphragmatic movement curve (AUDMC) were calculated by bedside ultrasound during quiet breathing (QB) and deep breathing (DB). Each parameter among three groups was analyzed separately by covariance analysis, which was adjusted by age, sex, body mass index, MAP, hypertension, and diabetes. First, contractile dysfunction occurred before diaphragmatic atrophy both in sepsis group 1 and sepsis group 2. Second, compared with the control group, the dynamic parameters showed significant decrease in sepsis group 1 and more obvious change in sepsis group 2, including TF, EQB/EDB. Third, the maximum contractile velocity decreased in sepsis group 1, reflecting the damage of intrinsic contraction efficiency accurately. Finally, per breathing AUDMC in two septic groups were lower than those in control group. However, per minute AUDMC was compensated by increasing respiratory rate in sepsis group 1, whereas it failed to be compensated which indicated gradual failure of diaphragm in sepsis group 2. Diaphragmatic ultrasound can be used to quantitatively evaluate the severity of sepsis patients whose contractile dysfunction occurred before diaphragmatic atrophy. As dynamic parameters, TF and EQB/EDB are early indicator associated with diaphragmatic injury. Furthermore, maximum contractile velocity can reflect intrinsic contraction efficiency accurately. AUDMC can evaluate diaphragmatic breathing effort and endurance to overcome resistance loads effectively.

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Section: Discussionsupporting

confidence: 88%

Quantification of diaphragmatic dynamic dysfunction in septic patients by bedside ultrasound

Chen

Liu

Han

et al. 2022

Sci Rep

View full text Add to dashboard Cite

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Neuregulin-1β attenuates sepsis-induced diaphragm atrophy by activating the PI3K/Akt signaling pathway

Liu

Chu

et al. 2019

J Muscle Res Cell Motil

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The reduced contraction capacity of palatopharyngeal muscle in OSAHS is related to the decreased intra-cellular [Ca2+] mediated by low RyR1 and DHPRα1s expression

Wang

Zhao

et al. 2022

Sleep Breath

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Decreased intracellular [Ca²⁺] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis

Abstract: Decreased intracellular [Ca ] coincides with diaphragmatic contractility and decreased expression of DHPRα1s and RyR1 in sepsis. Muscle Nerve 56: 1128-1136, 2017.

Cited by 4 publications

References 42 publications

Quantification of diaphragmatic dynamic dysfunction in septic patients by bedside ultrasound

Quantification of diaphragmatic dynamic dysfunction in septic patients by bedside ultrasound

Neuregulin-1β attenuates sepsis-induced diaphragm atrophy by activating the PI3K/Akt signaling pathway

The reduced contraction capacity of palatopharyngeal muscle in OSAHS is related to the decreased intra-cellular [Ca2+] mediated by low RyR1 and DHPRα1s expression

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Decreased intracellular [Ca2+] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis

Abstract: Decreased intracellular [Ca ] coincides with diaphragmatic contractility and decreased expression of DHPRα1s and RyR1 in sepsis. Muscle Nerve 56: 1128-1136, 2017.

Cited by 4 publications

References 42 publications

Quantification of diaphragmatic dynamic dysfunction in septic patients by bedside ultrasound

Quantification of diaphragmatic dynamic dysfunction in septic patients by bedside ultrasound

Neuregulin-1β attenuates sepsis-induced diaphragm atrophy by activating the PI3K/Akt signaling pathway

The reduced contraction capacity of palatopharyngeal muscle in OSAHS is related to the decreased intra-cellular [Ca2+] mediated by low RyR1 and DHPRα1s expression

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Decreased intracellular [Ca²⁺] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis