Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naïve Patients With Obsessive-Compulsive Disorder

Chen, Yun-Hui; Li, Sufang; Lv, Dan; Zhu, Guoqi; Wang, Yuhua; Meng, Xin; Hu, Qiang; Li, Chengchong; Zhang, Liangtang; Chu, Xiang‐Ping; Wang, Xiaoping; Li, Ping

doi:10.3389/fnins.2018.00889

Cited by 26 publications

(23 citation statements)

References 37 publications

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“…Diverse studies typically generate inconsistent results (2). Furthermore, some studies have focused on the networks of interest and ignored the most crucial brain areas involved in the core pathological abnormalities in OCD (12,13,15,(28)(29)(30). By contrast, in the present research, we used a voxel-wise brain-wide method to focus on FC alterations in drug-naive patients with OCD at rest.…”

Section: Discussionmentioning

confidence: 90%

“…As an important member in the triple network model, the SN filters and detects the external and internal salient information, and has an important role in supervising the interactions between the DMN and ECN (8). In our previous study, decreased FC strength within the SN, between the SN and ECN, and the DMN in OCD at rest was revealed (15). In that study, we only focused on the SN and ignored other important brain regions involved in OCD.…”

Section: Discussionmentioning

confidence: 99%

“…Increased FC and/or regional homogeneity within the DMN, ECN, and SN at rest were found through using the independent component analysis and regions of interest (ROI) seed-based FC approaches (8)(9)(10)(11)(12). By contrast, neuroimaging studies have reported decreased FC within the DMN, ECN, and SN at rest in OCD (2,(13)(14)(15). Two main factors may explain the inconsistency of the findings.…”

Section: Introductionmentioning

confidence: 99%

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Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder

Cui

Chen

et al. 2020

Front. Psychiatry

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Abnormal functional connectivity (FC) within discrete brain networks is involved in the pathophysiology of obsessive-compulsive disorder (OCD) with inconsistent results. In the present study, we investigated the FC patterns of 40 drug-naive patients with OCD and 38 healthy controls (HCs) through an unbiased voxel-wise global brain FC (GFC) analysis at rest. Compared with HCs, patients with OCD showed decreased GFC within the default mode network (DMN) (i.e., left posterior cingulate cortex/lingual gyrus) and sensorimotor network (i.e., left precentral gyrus/postcentral gyrus) and increased GFC within the executive control network (ECN) (i.e., left dorsal lateral prefrontal cortex and left inferior parietal lobule). Receiver operating characteristic curve analyses further indicated that the altered GFC values within the DMN, ECN, and sensorimotor network may be used as neuroimaging markers to differentiate patients with OCD from HCs. These findings indicated the aberrant FC patterns of the DMN, ECN, and sensorimotor network associated with the pathophysiology of OCD and provided new insights into the changes in brain organization function in OCD.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder

Cui

Chen

et al. 2020

Front. Psychiatry

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“…Previous static rfMRI studies in patients with OCD found decreased FC between DMN and SAN and other task‐positive networks (Chen et al, 2018; Cyr et al, 2020), and a meta‐analysis of static FC studies found hypoconnectivity among FPN, SAN, and DMN (Gursel et al, 2018). The present findings suggest that a higher occurrence of a state with the lowest FC between networks might be the neural substrate for the decreased static FC between DMN and SAN in OCD.…”

Section: Discussionmentioning

confidence: 94%

Altered brain functional network dynamics in obsessive–compulsive disorder

Luo

You

et al. 2021

Human Brain Mapping

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Obsessive–compulsive disorder (OCD) is a debilitating and disabling neuropsychiatric disorder, whose neurobiological basis remains unclear. Although traditional static resting‐state magnetic resonance imaging (rfMRI) studies have found aberrant functional connectivity (FC) in OCD, alterations in whole‐brain FC and topological properties in the context of brain dynamics remain relatively unexplored. The rfMRI data of 29 patients with OCD and 40 healthy controls were analyzed using group independent component analysis to obtain independent components (ICs) and a sliding‐window approach to generate dynamic functional connectivity (dFC) matrices. dFC patterns were clustered into three reoccurring states, and state transition metrics were obtained. Then, graph‐theory methods were applied to dFC matrices to calculate the variability of network topological organization. The occurrence of a state (State 1) with the highest modularity index and lowest mean FC between networks was increased significantly in OCD, and the fractional time in brain State 1 was positively correlated with anxiety level in patients. State 1 was characterized by having positive connections within default mode (DMN) and salience networks (SAN), and negative coupling between the two networks. Additionally, ICs belonging to DMN and SAN showed lower temporal variability of nodal degree centrality and efficiency in patients, which was related to longer illness duration and higher current obsession ratings. Our results provide evidence of clinically relevant aberrant dynamic brain activity in OCD. Increased functional segregation among networks and impaired functional flexibility in connections among brain regions in DMN and SAN may play important roles in the neuropathology of OCD.

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“…Apart from structural abnormalities, functional studies also highlight the importance of trans‐callosal connectivity alterations in OCD. Adult patients with OCD have been reported to have decreased functional connectivity between the right ventral lateral prefrontal cortex and left insula (Chen et al., 2018) and decreased voxel‐mirrored homotopic connectivity in the precentral gyrus and orbitofrontal cortex (Deng et al., 2019). Additionally, increased functional frontal asymmetry in patients with OCD has been observed in electroencephalography studies (Perera et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Microstructural white matter abnormalities in pediatric and adult obsessive‐compulsive disorder: A systematic review and meta‐analysis

Zhao

Huang

et al. 2020

Brain and Behavior

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Objective To identify the most prominent and replicable fractional anisotropy (FA) alterations of white matter associated with obsessive‐compulsive disorder (OCD) in tract‐based spatial statistics (TBSS) studies. Methods We reviewed previous TBSS studies (n = 20) in OCD and performed a meta‐analysis (n = 16) of FA differences. Results No between‐group differences in FA were detected in the pooled meta‐analysis. However, reduced FA was identified in the genu and anterior body of corpus callosum (CC) in adult OCD. FA reductions in the anterior body of CC were associated with a later age of onset in adult patients with OCD. For pediatric OCD, decreased FA in earlier adolescence and increased FA in later adolescence were seemingly related to an altered trajectory of brain maturation. Conclusions Absent in the pooled sample but robust in adults, disrupted microstructural organization in the anterior part of CC indicates a bias of deficits toward connections in interhemispheric connections of rostral neocortical regions, which could lead to deficits of interhemispheric communication and thus contribute to cognitive and emotional deficits in adult OCD. The correlation between FA in the anterior body of CC and older illness onset suggests that patients with later adult onset of illness may represent a biologically distinct subgroup. For pediatric OCD, alterations in neurodevelopmental maturation may contribute to inconsistent patterns of FA alteration relative to controls during adolescence. While most studies of OCD have emphasized alterations of within hemisphere fronto‐striatal circuits, these results indicate that between hemisphere connectivity of this circuitry may also represent important pathophysiology of the illness.

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Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naïve Patients With Obsessive-Compulsive Disorder

Cited by 26 publications

References 37 publications

Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder

Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder

Altered brain functional network dynamics in obsessive–compulsive disorder

Microstructural white matter abnormalities in pediatric and adult obsessive‐compulsive disorder: A systematic review and meta‐analysis

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