Decreased islet sensitivity to insulin in hamsters with dietary-induced insulin resistance

Francini, Flavio; Gagliardino, Juan José; Borelli, María Inés

doi:10.1016/j.lfs.2008.01.012

Cited by 6 publications

(3 citation statements)

References 57 publications

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“…Alternatively, impaired insulin‐stimulated insulin secretion in insulin‐resistant individuals may be just another facet of systemic insulin resistance. Thus, impaired insulin action at peripheral level (liver, muscle, fat) may also occur in pancreatic beta cells as found in a rodent model of diet‐induced insulin resistance . If insulin plays a meaningful physiological role regulating its own secretion, then impaired beta cell insulin signalling may lead to decreased insulin secretion.…”

Section: Novel Insights About the Interaction Between Insulin Secretimentioning

confidence: 98%

Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion

et al. 2014

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Pancreatic beta cells sense glucose flux and release as much insulin as required in order to maintain glycaemia within a narrow range. Insulin secretion is regulated by many factors including glucose, incretins, and sympathetic and parasympathetic tones among other physiological factors. To identify the mechanisms linking obesity-related insulin resistance with impaired insulin secretion represents a central challenge. Recently, it has been argued that a crosstalk between skeletal muscle and the pancreas may regulate insulin secretion. Considering that skeletal muscle is the largest organ in non-obese subjects and a major site of insulin- and exercise-stimulated glucose disposal, it appears plausible that muscle might interact with the pancreas and modulate insulin secretion for appropriate peripheral intracellular glucose utilization. There is growing evidence that muscle can secrete so-called myokines that can have auto/para/endocrine actions. Although it is unclear in which direction they act, interleukin-6 seems to be a possible muscle-derived candidate protein mediating such inter-organ communication. We herein review some of the putative skeletal muscle-derived factors mediating this interaction. In addition, the evidence coming from in vitro, animal and human studies that support such inter-organ crosstalk is thoroughly discussed.

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Section: Novel Insights About the Interaction Between Insulin Secretimentioning

confidence: 98%

Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion

et al. 2014

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“…37 Impairment of this insulin-positive feedback effect significantly decreases islet glucose metabolism and insulin release in animals with genetic or dietary-induced insulin resistance. 38 . These INGAP-PP-mediated changes would result in a more robust β cell to release insulin and to react against the deleterious effect of streptozotocin, 9,26 oxidative stress, 39 and endoplasmic reticulum stress.…”

Section: Discussionmentioning

confidence: 99%

Role of Islet Glucokinase, Glucose Metabolism, and Insulin Pathway in the Enhancing Effect of Islet Neogenesis-Associated Protein on Glucose-Induced Insulin Secretion

Maiztegui¹,

Román²,

Barbosa-Sampaio³

et al. 2015

Pancreas

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“…13,44,45 Metabolites M130 and M226 might also enter saccharide metabolism further oxidized to H 2 O and CO 2 in the plants. 46,47 Additionally, two metabolites, adenine and hypoxanthine, may be generated accompanying by M226, and they were also endogenous substances and could be metabolized via catabolic pathway of allantoin under urease catalyzing. 48 However, we could not certify the hypothesis due to the background concentrations of adenine and hypoxanthine in enzyme extract solution, the cell incubation system, and seedlings.…”

Section: Major Biotransformation Mechanism and Metabolism Rules Of Gu...mentioning

confidence: 99%

Uptake and Biotransformation of Guvermectin in Three Crops after In Vivo and In Vitro Exposure

Shi,

Pan,

et al. 2024

J. Agric. Food Chem.

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Guvermectin, as a novel nucleoside-like biopesticide, could increase the rice yield excellently, but the potential environmental behaviors remain unclear, which pose potential health risks. Therefore, the uptake and biotransformation of guvermectin in three types of crops (rice, lettuce, and carrot) were first evaluated with a hydroponic system. Guvermectin could be rapidly absorbed and reached equilibrium in roots (12−36 h) and shoots (24−60 h) in three plants, and guvermectin was also vulnerable to dissipation in roots (t 1/2 1.02−3.65 h) and shoots (t 1/2 9.30−17.91 h). In addition, 8 phase I and 2 phase II metabolites, transformed from guvermectin degradation in vivo and in vitro exposure, were identified, and one was confirmed as psicofuranine, which had antibacterial and antitumor properties; other metabolites were nucleoside-like chemicals. Molecular simulation and quantitative polymerase chain reaction further demonstrated that guvermectin was metabolized by the catabolism pathway of an endogenous nucleotide. Guvermectin had similar metabolites in three plants, but the biotransformation ability had a strong species dependence. In addition, all the metabolites exhibit neglectable toxicities (bioconcentration factor <2000 L/kg b.w., LC 50,rat > 5000 mg/kg b.w.) by prediction. The study provided valuable evidence for the application of guvermectin and a better understanding of the biological behavior of nucleoside-like pesticides.

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Decreased islet sensitivity to insulin in hamsters with dietary-induced insulin resistance

Cited by 6 publications

References 57 publications

Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion

Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion

Role of Islet Glucokinase, Glucose Metabolism, and Insulin Pathway in the Enhancing Effect of Islet Neogenesis-Associated Protein on Glucose-Induced Insulin Secretion

Uptake and Biotransformation of Guvermectin in Three Crops after In Vivo and In Vitro Exposure

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