Decreased Levels of Plasma Vitamin C and Increased Concentrations of Inflammatory and Oxidative Stress Markers After Stroke

Abstract

Background and Purpose-Inflammatory response is a critical component of the complex pathophysiological response to stroke. Vitamin C has been shown to have important roles in cell performance and vascular function. In this study, we compared the nutritional status and levels of inflammatory markers between stroke cases and controls and assessed which antioxidant was associated with levels of inflammatory markers and oxidative stress among cases and controls. Methods-We evaluated the nutritional status and measured plasma levels of vitamins C and E, uric acid, serum levels of C-reactive protein (CRP), the cytokines tumor necrosis factor-␣ and interleukin-1␤, intercellular adhesion molecule-1 (ICAM-1) and chemokine monocyte chemoattractant protein-1 (MCP-1), prostaglandins PGE2 and PGI2, and 8-isoprostanes (8-epiPGF 2␣ ) for 15 patients with ischemic stroke within 2 to 5 days after stroke onset and for 24 control subjects. Results-Stroke patients had significantly lower plasma levels of vitamin C than did controls. Among stroke patients, CRP was significantly elevated, as were the ICAM-1, MCP-1, and 8-epiPGF 2␣ , but the prostaglandins PGE2 and PGI2 were significantly reduced. Interestingly, vitamin C concentration was significantly inversely correlated with the levels of CRP and 8-epiPGF 2␣ among stroke patients, and 8-epiPGF 2␣ was significantly associated with the levels of CRP. Uric acid was also elevated among stroke patients. Conclusions-Lower

Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident ( Ischaemic Stroke ) : The Role of Ginkgo Biloba Extract

“…40 Evaluations of antioxidants in blood, urine, or cerebrospinal fluid of ischaemic stroke patients revealed lower plasma vitamin C, E, vitamin A, and uric acid, lower glutathione peroxidase (GPX) activity, decreased glutathione (GSH) concentration, and a decreased total plasma antioxidant capacity. 8,10,32,34,35,37,41 Data associated with superoxide dismutase (SOD) activity after acute ischaemic stroke are controversial. SOD activity of patients with acute ischaemic stroke was reported to be reduced in the serum and increased in the cerebrospinal fluid (CSF), increased in both CSF and serum, or remained unchanged.…”

Prostaglandin E2 Inhibits Its Own Renal Transport by Downregulation of Organic Anion Transporters rOAT1 and rOAT3

“…In general, information on plasma concentrations of PGE 2 in fever is meagre. The mean plasma concentration of PGE 2 is approximately 1 to 10 nM in resting and healthy humans (39). Plasma levels in rabbit LPS fever models rise approximately four-fold after a single injection of LPS (17).…”

Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

“…Several studies have indicated that isoprostanes are reliable markers for examining oxidative stress under in vivo conditions. Sanchez-Moreno et al (27) reported that F2-isoprostane 8-epiPGF2α plasma was significantly greater in the stroke group than the control group. They assessed the presence of metabolites derived from prostaglandin, which were formed by random oxidation of tissue phospholipids via oxygen radicals.…”

“…There was also a significant difference between the sub-groups of IS in terms of F2-isoprostane levels. F2-isoprostanes, also called 8-epi PGF2α, are of particular interest to researchers because they have platelet vasoconstriction activation properties as well as mitogenic properties (27).…”