Decreased Lithium Disposition to Cerebrospinal Fluid in Rats with Glycerol-induced Acute Renal Failure

Sakae, Rie; Ishikawa, Atsuko; Niso, Tomoko; Komori, Yukiko; Aiba, Tetsuya; Kawasaki, Hiromu; Kurosaki, Yuji

doi:10.1007/s11095-008-9612-5

Cited by 13 publications

(21 citation statements)

References 48 publications

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“…They were allowed free access to a standard laboratory diet and water prior to the experiments. To prepare ARF rats, each rat was injected with 10 ml/kg of 50% glycerol in the left and right femoral muscles after 24 h of water deprivation [12,13]. They were fed normally thereafter, and used in the experiments 24 h after the glycerol injection.…”

Section: Animalsmentioning

confidence: 99%

“…They were fed normally thereafter, and used in the experiments 24 h after the glycerol injection. The development of renal failure was confirmed with a significant increase in the serum creatinine concentration [12]. All animal experiments were performed in accordance with the guidelines for animal experimentation of Okayama University.…”

Section: Animalsmentioning

confidence: 99%

“…At first, prior to each experiment, the permeation coefficient of the microdialysis probe was determined [12,18]. The microdialysis probe used was provided as an assembly equipped with a semi-permeable cellulose membrane (A-I-8, Eicom, Kyoto, Japan).…”

Section: Evaluation Of Marker Electrolyte Transport From Plasma To Csfmentioning

confidence: 99%

“…Then, a hole 1 mm in diameter was carefully opened by drilling the skull without damaging brain tissue, and a guide cannula (AG-8, Eicom) was inserted into the brain tissue through the hole to place its tip in the right lateral ventricle. After the guide cannula was properly fixed to the skull, the microdialysis probe was inserted into the ventricle through the cannula, and the tip of the probe's semi-permeable membrane was located precisely at the following brain atlas coordinates originating from the bregma: anterior, 0.0 mm; lateral, 1.5 mm; ventral, 3.2 mm [12,19]. The inlet and outlet tubes of the probe were connected to a syringe infusion pump (CMA/102) and a fraction collector (CMA/142), respectively, and the probe's lumen began to be perfused with Ringer's solution at a rate of 0.5 ml/min.…”

Section: Evaluation Of Marker Electrolyte Transport From Plasma To Csfmentioning

confidence: 99%

“…In our previous study, it was demonstrated that the expression of the Na 1 /K 1 /2Cl À cotransporter (NKCC1) increases in the choroid plexus of ARF rats [12]. This suggests that the choroid plexial function of transporting electrolytes alters in ARF rats, but the precise mechanism leading to the alteration, including the influence of an increased NKCC1 expression on the electrolyte handling of the choroid plexus, remains to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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Altered electrolyte handling of the choroid plexus in rats with glycerol‐induced acute renal failure

Ishikawa

Kono

Sakae

et al. 2010

Biopharm & Drug Disp

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The altered electrolyte handling of the choroid plexus was investigated in rats with acute renal failure (ARF) using lithium and rubidium as surrogate markers for sodium and potassium, respectively. Firstly, the transport of these two markers from the plasma to cerebrospinal fluid (CSF) was evaluated after they were concurrently injected into the femoral vein. As a result, their disposition from the plasma to CSF was shown to decrease in ARF rats, but the relationship profile between those two markers was not different from that observed in normal rats, indicating that the decreased disposition of lithium and rubidium occurs without affecting the stoichiometric balance. To clarify the mechanisms accounting for the decreased disposition, an inhibition study was then performed. When bumetanide, an inhibitor of the Na(+) /K(+) /2Cl(-) co-transporter, was directly introduced into the cerebroventricle prior to lithium and rubidium being intravenously administered, a marked increase in the markers' disposition was observed. However, such an increased disposition did not occur when bumetanide was injected into the femoral vein. Other inhibitors, such as amiloride for the Na(+) /H(+) exchanger and ouabain for Na(+) /K(+) -ATPase, did not show any effects on marker disposition regardless of the inhibitor being administered into either the cerebroventricle or femoral vein. These findings suggest that the decreased marker disposition in ARF rats is due to an increased efflux process of the choroid plexus mediated by the Na(+) /K(+) /2Cl(-) co-transporter. That is, electrolyte efflux from the CSF to plasma increases, and thereby the electrolyte influx from the plasma to CSF is counteracted.

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Section: Animalsmentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

Section: Evaluation Of Marker Electrolyte Transport From Plasma To Csfmentioning

confidence: 99%

Section: Evaluation Of Marker Electrolyte Transport From Plasma To Csfmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Altered electrolyte handling of the choroid plexus in rats with glycerol‐induced acute renal failure

Ishikawa

Kono

Sakae

et al. 2010

Biopharm & Drug Disp

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Comparative study on altered hepatic metabolism of CYP3A substrates in rats with glycerol‐induced acute renal failure

Kusaba

Kajikawa

Kawasaki

et al. 2012

Biopharm & Drug Disp

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To examine the mechanism accounting for the diverse alteration of hepatic metabolism of CYP3A substrates observed with renal function being severely impaired, the hepatic drug metabolizing activity was evaluated using liver microsomes prepared from rats with glycerol-induced acute renal failure (ARF). Midazolam, nifedipine and rifabutin were employed as representative CYP3A substrates. When the Michaelis-Menten parameters, K(m) and V(max) , were examined in the incubation study, the K(m) values of midazolam and nifedipine in ARF rats were shown to decrease by 50.9% and 29.9% compared with the normal value, respectively. The V(max) values of midazolam and nifedipine in ARF rats also decreased by 49.3% and 28.0%, respectively, showing that their decreased K(m) values accompanied the decreased V(max) values. The parameters of nifedipine seemed to alter to a lesser extent than those of midazolam. As for rifabutin metabolism, the decrease in the K(m) value was observed in ARF rats, but it did not accompany the decrease in the V(max) value. Then, the hepatic expressions of the CYP3A subfamily were examined with western blotting using anti-CYP3A1 and anti-CYP3A2 antibodies. It was revealed that the hepatic expression of CYP3A2 decreased, while that of CYP3A1 was unaffected. Additionally, a band signal deduced to originate from CYP3A9 was clearly detected in ARF, but not in normal rats. Considering each substrate having different specificities for CYP3A subfamily member proteins, individual alterations of hepatic CYP3A subfamily expression seem to underlie the diverse alterations of hepatic metabolism of CYP3A substrates in ARF rats.

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Na+/H+ Exchanger 1 Gene Expression in Tissues of Yellow Chicken

Ning

et al. 2011

Biochem Genet

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The Na(+)/H(+) exchanger 1 (NHE1) transmembrane protein regulates intracellular pH, cell survival, cell growth, cell differentiation and plays a critical role in the progression of some diseases, including the pathogenesis of J avian leukosis. The chicken is an ideal model to study the function of NHE1 because it has developed highly efficient Na(+)-absorptive mechanisms in its small and large intestines. To date, there has been no detailed expression analysis to determine NHE1 expression in various tissues of the chicken. We determined the mRNA and protein expression levels of avian NHE1 by real-time quantitative PCR and immunohistochemical analysis. NHE1 mRNA was detected in all chicken tissues examined. Protein expression levels varied widely among tissues and did not always correlate with mRNA expression. Determining the mRNA and protein of NHE1 expression patterns in chicken should help to delineate the NHE1 role in different tissues and its contribution to physiological and pathological processes. These data provide the basis for examining the distinct function of chicken NHE1 compared with its mammalian counterpart.

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Decreased Lithium Disposition to Cerebrospinal Fluid in Rats with Glycerol-induced Acute Renal Failure

Abstract: ARF decreases the lithium disposition to CSF, possibly by promoting lithium efflux from CSF due to increased NKCC1 expression in the choroid plexus.

Cited by 13 publications

References 48 publications

Altered electrolyte handling of the choroid plexus in rats with glycerol‐induced acute renal failure

Altered electrolyte handling of the choroid plexus in rats with glycerol‐induced acute renal failure

Comparative study on altered hepatic metabolism of CYP3A substrates in rats with glycerol‐induced acute renal failure

Na+/H+ Exchanger 1 Gene Expression in Tissues of Yellow Chicken

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