2022
DOI: 10.3892/etm.2022.11531
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Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator

Abstract: Pulmonary arterial hypertension (PAH) is commonly associated with systemic lupus erythematosus (SLE). The present study investigated the relationship between coagulation and changes in lipid parameters in newly-diagnosed patients with SLE in the presence of PAH and whether the coagulation parameters were mediators between lipids and PAH presence. A total of 301 subjects scheduled for new-onset drug-naïve SLE were consecutively enrolled. Baseline data for patients without PAH and with PAH were gathered and comp… Show more

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Cited by 5 publications
(4 citation statements)
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“…Low LDL may serve as an indicator of disease severity and prognosis in patients with PH, and LDL's anti-inflammatory properties may be relevant ( 27 ). We also found low LDL in CTD-PAH patients ( 28 ). Until recently, the exact mechanisms accounting for the association between low LDL and PH have been obscure, possible explanations include a chronic inflammatory state ( 29 ), malnutrition ( 30 ), and altered liver metabolism ( 31 ).…”
Section: Discussionsupporting
confidence: 62%
“…Low LDL may serve as an indicator of disease severity and prognosis in patients with PH, and LDL's anti-inflammatory properties may be relevant ( 27 ). We also found low LDL in CTD-PAH patients ( 28 ). Until recently, the exact mechanisms accounting for the association between low LDL and PH have been obscure, possible explanations include a chronic inflammatory state ( 29 ), malnutrition ( 30 ), and altered liver metabolism ( 31 ).…”
Section: Discussionsupporting
confidence: 62%
“…These factors play a regulatory role in the functions of both osteoclasts and osteoblasts ( Figure 2 ). On the other hand, the levels of fibrinolysis markers such as D-dimer and fibrin degradation products (FDP), as well as fibrinolytic factors in samples from patients with chronic inflammatory diseases like rheumatoid arthritis [ 38 , 39 , 40 , 41 ], systemic lupus erythematosus [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ], Crohn’s disease [ 50 , 51 , 52 , 53 ], and periodontitis [ 54 , 55 , 56 ], are higher than those in healthy controls ( Figure 3 ). These factors are associated with the pathology of chronic inflammatory diseases and may play a critical role in the context of inflammatory bone destruction.…”
Section: The Role Of Fibrinolytic Factors In Bone Homeostasis and Inf...mentioning
confidence: 99%
“…78 D-dimer levels are a known predictive factor for PAH and may act as a mediator of reduced low-density lipoprotein (LDL), although optimal cutoff points and estimations of individual pressure ranges are unknown. 92 Patients with SLE may benefit from PH screening using transthoracic ECG, lung function tests (forced vital capacity and diffusion lung capacity for carbon monoxide) and an N-terminal pro-B-type natriuretic peptide (NT-proBNP) test, particularly in combination. 93 Moreover, genetic phenotyping may be a standard beneficial option in the future.…”
Section: Pulmonary Hypertensionmentioning
confidence: 99%