Decreased microcirculatory function measured by perfusion index is a novel indicator of diabetic kidney disease in patients with type 2 diabetes

Abstract

Aims/Introduction: Diabetic kidney disease has been considered as an important risk factor of cardiovascular disease. Chronic hypoxia is considered to be the main cause of renal injury. Diminished microcirculatory blood flow could be associated with hypoxia in the kidney. Whether diminished microcirculation is associated with diabetic kidney disease has not yet been reported. Here, we investigated the correlation between microcirculatory function and diabetic kidney disease in patients with type 2 diabetes. Materials and Methods: Our cross-sectional study included 574 patients who were admitted to Matsushita Memorial Hospital in Moriguchi, Japan, for type 2 diabetes. Microcirculatory function was assessed using the perfusion index (PI), which represents the level of circulation through peripheral tissues. We measured the PI for all patients. Results: The median age and PI values were 70 years (range 60-77 years) and 2.8% (range 1.6-4.8%). Multiple regression analyses showed that the PI independently correlated with the logarithm of urinary albumin excretion (P = 0.009) and estimated glomerular filtration rate (P = 0.005), respectively. Multiple logistic regression analyses showed that patients with systolic blood pressure (SBP) greater than the median and PI less than or equal to the median (high-low group) had a significantly increased odds of albuminuria compared with those with SBP less than or equal to the median and PI greater than the median (low-high group), and patients with SBP greater than the median and PI less than or equal to the median (high-low group) had a significantly increased odds of estimated glomerular filtration rate <60 mL/min per 1.73 m 2 compared with those with SBP less than or equal to the median and PI greater than the median (low-high group) or SBP greater than the median and PI greater than the median (high-high group). Conclusions: PI could be a novel indicator of diabetic kidney disease in patients with type 2 diabetes.

Correlation of ACR and TcPO2 in diabetic kidney disease patients: A pilot study

“…High systolic blood pressure or low perfusion index had markedly increased odds of ACR and eGFR. 15 Clinically, TcPO2 was also frequently used as a useful tool to assess microcirculation in diabetic patients. Previous study indicated optimal cutoff point (19.5 mm Hg) yielded a sensitivity of 0.611 and a specificity of 0.738 for predicting DPN.…”

Effect of Aerobic Exercise on Microcirculation in Sedentary College Students

“…5 Transcutaneous oxygen pressure (TcPO2) is the oxygen content of capillaries that diffuse through the skin, It can be used for the evaluation of skin blood flow perfusion volume and microcirculation function. 6 Muscle oxygen Saturation (SmO2) reflects muscle oxygen supply balance and muscle generation Xie's important indicator has a close relationship to TcPO2. 7 Based on this, In this study, aerobic exercise and aerobic were formulated to FATmax as exercise intensity standard In combination with the resistance exercise protocol, 10 weeks of aerobic exercise and aerobic binding resistance were explored Shadow of exercise on microvascular reactivity, TcPO2 and SmO2 in obese college students Ring, and explore the possible mechanism of exercise to improve the microcirculation function, to improve fertilizer.…”

<p>Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats</p>

“…10 Thus, renal injury is often caused by I/R treatment in diabetes. 11,12 However, studies on the renal I/R injury in diabetes are still inadequate nowadays.…”