Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption

Laso, Francisco‐Javier; Madruga, J. I.; Giron, J; López, Antonio; Ciudad, Juana; Miguel, Jesús F. San; Álvarez‐Mon, Melchor; Órfão, Alberto

doi:10.1002/hep.510250508

Cited by 106 publications

(77 citation statements)

References 8 publications

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“…Another study with acute ETOH consumption (blood ETOH levels 8.7 and 19.3 mM) also did not observe a change in NK cell lytic activity (OchshornAdelson et al, 1994). In contrast, chronic alcoholics without liver disease were shown to have a significantly increased number of NK cells and a parallel increase in NK cell lytic activity (Laso et al, 1997). Several studies have investigated the effect of wine flavonoids on NK cell function.…”

Section: Discussionmentioning

confidence: 99%

Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men

et al. 2003

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Objective: To investigate whether the daily intake of red wine (RW) at a dose which inversely correlates with cardiovascular disease (CVD) risk modulates immune functions in healthy men. Design: Randomized single-blind trial with four intervention periods. Setting: The Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany. Subjects: A total of 24 healthy males with moderate alcohol consumption patterns were recruited and all completed the study. Intervention: Participants consumed 500 ml of RW (12% ethanol (ETOH)) or 500 ml of a 12% ETOH dilution per day for a period of 2 weeks. To control the potential effects of RW polyphenols, accordingly 500 ml/day of dealcoholized red wine (DRW) and of red grape juice (RGJ) were given. The following immune parameters were measured before beverage consumption and at 1 and 2 weeks following beverage consumption: phagocytic activity of neutrophils and monocytes, production of tumor necrosis factor-alpha (TNFa), interleukin-2 and -4, transforming growth factor-b, TNFa mRNA, lymphocyte proliferation, lytic activity of natural killer cells, and percentage of apoptotic lymphocytes. Results: Consumption of a moderate volume of alcohol with RW and with a 12% ETOH dilution had no effect on immune functions in healthy males. Consumption of polyphenol-rich beverages (DRW and RGJ) did not affect immunity-related parameters. Conclusions: Daily moderate consumption of alcohol and of RW for 2 weeks at doses which inversely correlate with CVD risk has no adverse effects on human immune cell functions. Polyphenol-rich beverages such as RGJ and DRW further do not suppress immune responses in healthy men.

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Section: Discussionmentioning

confidence: 99%

Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men

et al. 2003

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“…A decrease in monocyte function, characterized by a deficiency in adherence and phagocytosis, has been detected [3,4]. Similarly, alterations in natural killer activity [5] and lectin-induced proliferation of T lymphocytes have both been described [6]. However, an increase of serum immunoglobulin concentration is present in patients with liver cirrhosis, and this is possibly indicative of an altered balance between T lymphocyte helper responses implicated in cytotoxicity [T helper type 1 (Th1)] and those implicated in the synthesis of specific antibodies (Th2) [7,8].…”

Section: Introductionmentioning

confidence: 91%

Chronic antigenic stimuli as a possible explanation for the immunodepression caused by liver cirrhosis

Márquez¹,

Fernández-Gutiérrez²,

Montesdeoca³

et al. 2009

Clinical and Experimental Immunology

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SummaryThe objectives of this work were the analysis of the functional characteristics of circulating monocytes and T lymphocytes in patients with liver cirrhosis, and evaluation of the relationship with an increased exposure to antigens due to bacterial translocation. Forty patients with liver cirrhosis (20 with compensated cirrhosis and 20 with ascitic decompensation) and 20 healthy control subjects were studied. Bacterial translocation was evaluated by serum levels of lipopolysaccharide binding protein (LBP). Macrophage activation was studied by CD40 antigen expression. T lymphocytes were analysed for activation (CD25 + , CD122 + ), effector function (CD8 + CD45RO + CD57 + ), apoptosis (CD95 + ) and regulatory abilities, either by analysis of the membrane expression of co-stimulatory molecules CD80, CD86 and CD28, or by quantification of regulatory T cells CD4 + CD25 high forkhead box P3 (FoxP3). The percentage of activated monocytes and T lymphocytes in patients was increased significantly. The proportions of effector senescent cells and of those near to apoptosis were also significantly higher. With respect to these proportions, there were no significant differences between patients in function of the presence or absence of decompensation or in function of the increased or normal values of LBP. Conversely, those patients with elevated levels of LBP presented a significantly higher frequency of regulatory T cells than those with normal levels. In conclusion, patients with liver cirrhosis showed an intensive activation state with a higher percentage of cells committed to activation-induced death, even in non-advanced stages. It is possible that bacterial permeability and endotoxaemia contribute to the expansion of those lymphocyte populations implicated in the prevention of a more severe antigen-induced immunopathology.

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“…Peripheral blood samples were analyzed by direct immunofluorescence, as previously described (15). Monoclonal antibodies directed against membrane antigens were employed to characterize the following subpopulations: anti-CD3 (pan-T) and anti-CD16/56 (pan-NK) (Becton-Dickinson, Mountain View, CA, USA).…”

Section: Immunological Marker Analysismentioning

confidence: 99%

Serial analysis of the effects of methimazole or radical therapy on circulating CD16/56 subpopulations in Graves' disease

Rojano

Sasian²,

Gavilán³

et al. 1998

European Journal of Endocrinology

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The distribution of peripheral blood CD16/56 cytotoxic T and natural killer (NK) cells in Graves' disease patients is analyzed in order to correlate them with disease activity and with prognosis. Eighteen patients with Graves' disease, twenty-four patients with Hashimoto's thyroiditis and thirtytwo sex-and age-matched healthy control subjects were studied. Peripheral blood CD16/56 (cytotoxic T and NK) cells were analyzed by cytofluorometry. A decreased proportion of CD16/56þ and CD16/ 56þCD3þ cells were detected in Graves' disease patients when compared with thyroiditis patients and healthy control groups. No correlation was detected with serum free thyroxine. On diagnosis, patients who would require a radical treatment for thyrotoxicosis control showed a significant decrease of cytotoxic CD56þ T (CD3þ) and NK (CD3¹) cells compared with those who would maintain the euthyroid state after methimazole. These results suggest that the cytotoxic compartment, both T and NK cells, of the immune system is altered in patients with Graves' disease, independently of the functional thyroid status. Changes in peripheral blood lymphocytes in Graves' disease patients could be useful as predictive markers of an unfavorable outcome.

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Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption

Cited by 106 publications

References 8 publications

Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men

Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men

Chronic antigenic stimuli as a possible explanation for the immunodepression caused by liver cirrhosis

Serial analysis of the effects of methimazole or radical therapy on circulating CD16/56 subpopulations in Graves' disease

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