Decreased Oxidative State in Non-Lesional Skin of Atopic Dermatitis

Antille, Christophe; Sorg, Olivier; Lübbe, Jann; Saurat, Jean‐Hilaire

doi:10.1159/000051814

Cited by 25 publications

(26 citation statements)

References 20 publications

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“…Alterations in antioxidant patterns, similar to those observed systemically, were found in involved skin of AD patients, whereas increased α‐tocopherol levels and decreased lipid peroxides have been found in non‐lesional skin 5 as a consequence of an adaptive response to a chronic inflammatory state of the epidermis.…”

Section: Action Of Ros and Lipids In The Development Of Skin Inflammamentioning

confidence: 55%

Antioxidant activity, lipid peroxidation and skin diseases. What's new

Briganti

Picardo

2003

Acad Dermatol Venereol

506

457

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Due to its interface function between the body and the environment, the skin is chronically exposed to both endogenous and environmental pro-oxidant agents, leading to the harmful generation of reactive oxygen species (ROS). There is compelling evidence that oxidative stress is involved in the damage of cellular constituents, such as DNA, cell membrane lipids or proteins. To protect the skin against the over-load of oxidant species, it contains a well-organised system of both chemical and enzymatic antioxidant which are able to work in a synergistic manner. Skin antioxidant network protects cells against oxidative injury and prevent the production of oxidation products, such as 4-hydroxy-2-nonenal or malonaldehyde, which are able to induce protein damage, apoptosis or release of pro-inflammatory mediators, such as cytokines. When oxidative stress overwhelms the skin antioxidant capacity the subsequent modification of cellular redox apparatus leads to an alteration of cell homeostasis and a generation of degenerative processes. Topical application or oral administration of antioxidants has been recently suggested as preventive therapy for skin photoaging and UV-induced cancer. The recognition that ROS can act as second messengers in the induction of several biological responses, such as the activation of NF-kB or AP-1, the generation of cytokines, the modulation of signalling pathways, etc., has led many researchers to focus on the possible effects of antioxidants in many pathological processes. The recent demonstration that the peroxisome proliferators-activated receptors, whose natural ligands are polyunsaturated fatty acids and theirs oxidation products, have a central role in the induction of some skin diseases, such as psoriasis or acne, has indicated new links between free radicals and skin inflammation. Based on these findings, the review summarises the possible correlations between antioxidant imbalance, lipid oxidative breakage and skin diseases, from both a pathological and therapeutic points of view.

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Section: Action Of Ros and Lipids In The Development Of Skin Inflammamentioning

confidence: 55%

Antioxidant activity, lipid peroxidation and skin diseases. What's new

Briganti

Picardo

2003

Acad Dermatol Venereol

506

457

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“…Positive staining with the anti-4-hydroxy-2-nonenal antibody was observed in the most superficial layers of the stratum corneum. The other group reported that the concentration of α-tocopherol in the stratum corneum was higher in scrapings of the nonlesional forearms of patients with atopic dermatitis than in samples collected from healthy control subjects [7]. However, they reported that the concentrations of lipid peroxides in the stratum corneum of the atopic dermatitis patients was slightly, but significantly, lower than that of normal controls.…”

Section: Elevation Of Reactive Oxygen Species/reactive Nitrogen Specimentioning

confidence: 96%

“…In view of the high lipid content of the stratum corneum, lipophilic antioxidants like α-tocopherol are expected to play a major role in scavenging reactive oxidant intermediates produced during oxidative stress. Two groups have directly measured the footprints of oxidative damage in the stratum corneum of patients with atopic dermatitis [6,7]. The concentrations of carbonyl moieties (markers of oxidative protein damage) were elevated in skin biopsies from 75 patients with atopic dermatitis in a manner that was directly correlated with the severity of the disease [6].…”

Section: Elevation Of Reactive Oxygen Species/reactive Nitrogen Specimentioning

confidence: 99%

Oxidative Stress in Allergic and Inflammatory Skin Diseases

Okayama

2005

CDTIA

229

157

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The skin is exposed to endogenous and environmental pro-oxidant agents, leading to the harmful generation of reactive oxygen species (ROS). The resulting oxidative stress damages proteins, lipids, and DNA. An imbalance between ROS and antioxidants can lead to an elevated oxidative stress level. Some evidence indicates that allergic and inflammatory skin diseases like atopic dermatitis, urticaria and psoriasis are mediated by oxidative stress. For example, monocytes from patients with atopic dermatitis are primed to generate ROS in response to zymosan, a Toll-like receptor 2 (TLR2) ligand, suggesting that Staphylococcus aureus may damage lesional skin of the disease by production of ROS. Mast cells generate mainly intracellular ROS following the aggregation of FceRI; these ROS may act as secondary messengers in the induction of several biological responses. The present review summarizes the involvement of ROS in the pathogenesis of allergic and inflammatory skin diseases.

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“…The last hypothesis could be the regeneration of vitamin E, a lipophilic antioxidant, by AA. Indeed, Antille et al [18]have recently shown that AD patients exhibit a two-fold higher α-tocopherol concentration in the stratum corneum. Besides, Solvoll et al [19]and Barth et al [20]have shown that AD patients have a significantly lower intake of fruits than healthy controls.…”

Section: Discussionmentioning

confidence: 99%

High Iron and Low Ascorbic Acid Concentrations in the Dermis of Atopic Dermatitis Patients

Lévêque¹,

Robin²,

Muret³

et al. 2003

Dermatology

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Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease in which reactive oxygen species (ROS) may be involved. Iron catalyses ROS formation and ascorbic acid (AA) scavenges these species. Objective: The aim of this work was to determine iron and AA levels in AD patients’ dermis and to compare their concentrations with those of healthy volunteers’ dermis. Methods: Five AD patients and 5 healthy subjects (controls) were enrolled in this study. Iron and AA were collected from human dermis by microdialysis and assessed by atomic absorption spectrometry and gas chromatography-mass spectrometry, respectively. Results: The AD dermis demonstrated higher iron concentrations (44.3 ± 4.6 µg/l) compared to controls (21.8 ± 1.2 µg/l) as well as a significantly lower concentration of AA (46.7 ± 0.6 vs. 176.8 ± 14.5 µg/ml, respectively). Conclusion: These results suggest that iron and AA dermis levels could be indicators of inflammatory tissues and might be implicated in dermatological diseases such as AD.

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Decreased Oxidative State in Non-Lesional Skin of Atopic Dermatitis

Cited by 25 publications

References 20 publications

Antioxidant activity, lipid peroxidation and skin diseases. What's new

Antioxidant activity, lipid peroxidation and skin diseases. What's new

Oxidative Stress in Allergic and Inflammatory Skin Diseases

High Iron and Low Ascorbic Acid Concentrations in the Dermis of Atopic Dermatitis Patients

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