Decreased peripheral benzodiazepine binding sites in platelets of neuroleptic-treated schizophrenics

Gavish, Moshe; Weizman, Abraham; Karp, Leon; Tyano, Sam; Tanne, Zehava

doi:10.1016/0014-2999(86)90500-5

Cited by 56 publications

(23 citation statements)

References 25 publications

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“…Furthermore, there were no direct significant cor relations between pre-or posttreatment estradiol levels and either the density or the affinity of [3H]PK 11195 for its binding sites during these periods. It is noteworthy that the range of Bmax and K<j values for [3H]PK 11195 binding observed in the present study is within the range reported for normal individuals in previous studies [Gavish et al, 1986aSuranyi-Cadotte et al, 1988] . The presence of normal range [3H]PK 11195 binding values during situations with both markedly reduced and raised estradiol levels further indicates that this gonadal steroid is not likely to exert significant effects on peripheral BZ binding sites on platelets.…”

Section: Discussionsupporting

confidence: 76%

“…The density of platelet peripheral BZ binding sites has previously been shown to be reduced in schizophrenia [Gavish et al, 1986a;Weizman et al, 1986] and anxiety disorder . Furthermore, there is evidence that 10 days estra diol administration to rats leads to an increase in kidney peripheral BZ binding while inducing a decrease of these sites in the testis [Gavish et al, 1986b].…”

Section: Discussionmentioning

confidence: 99%

“…Using [3H]PK 11195 as a selective ligand, previous studies have de scribed significant reductions in the density of platelet peripheral BZ binding sites in schizophrenia [Gavish et al, 1986a;Weizman et al, 1986] and anxiety disorder . In recent studies we found a sig nificant reduction in the density of platelet peripheral BZ binding sites in alcoholism [Suranyi-Cadotte et al, 1988] , a disorder which is reputedly associated with altered levels of adrenal and gonadal steroids [Van Thiel et al, 1975, 1978.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Increasing Estradiol Levels on Platelet Peripheral Benzodiazepine Binding Sites in Women Undergoing Human Menopausal Gonadotropin Treatment

Diorio

Welner²,

Tulandi³

et al. 1990

Neuropsychobiology

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The effect of increasing serum estradiol levels on platelet [³H]PK 11195 binding was investigated to determine the influence of gonadal steroids on platelet peripheral benzodiapezine binding sites. Serum estradiol and platelet [³H]PK 11195 binding were determined in 10 anovulatory, but otherwise healthy women before and after treatment with human menopausal gonadotropin. Despite a 30-fold increase in posttreatment estradiol, the kinetic parameters of platelet [³H]PK 11195 binding (K_d, B_max) remained essentially unchanged. These data indicate that peripheral benzodiazepine binding sites on platelets are not influenced by elevated concentrations of estradiol. Thus, it is suggested that variations in circulating levels of this female gonadal steroid are likely not responsible for the modifications in platelet peripheral benzodiazepine binding sites seen in association with various disease states.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Increasing Estradiol Levels on Platelet Peripheral Benzodiazepine Binding Sites in Women Undergoing Human Menopausal Gonadotropin Treatment

Diorio

Welner²,

Tulandi³

et al. 1990

Neuropsychobiology

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“…Recently, a decrease in PBS in platelets of schizophrenics treated for several years with neuroleptics has been observed (Gavish et al, 1986b;Weizman et al, 1986), although such an effect was not observed after only 28 days of treatment with antidopaminergic agents . Thus, it is possible that neuroleptic-induced down-regulation of platelet PBS may be a time-dependent phenomenon.…”

Section: Introductionmentioning

confidence: 97%

Effect of chronic haloperidol treatment on peripheral benzodiazepine binding sites in cerebral cortex of rats

Gavish

Weizman

Becker

et al. 1988

J. Neural Transmission

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The effects of 21 days of haloperidol treatment on central benzodiazepine (BZ) receptors in the cerebral cortex of rats and on peripheral-type BZ binding sites (PBS) in the cerebral cortex and heart of rats were studied. Neuroleptic treatment did not affect the maximal binding capacity or the affinity of the central BZ receptor to 3H-flunitrazepam. Chronic haloperidol treatment resulted in a significant increase of 38% in PBS density in the cerebral cortex, with no alteration in PBS density in the heart. No alteration in PBS affinity for its ligand 3H-PK 11195 was observed, either in the cerebral cortex or in the heart. The modulatory effect of chronic haloperidol administration on PBS density in the brain may be related to some of the neurobehavioral or hormonal effects of the drug.

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“…The binding of 'H-PK-l 1195 to platelet membranes was per formed according to a slight modification of the method of Gavish et al [30], Four hundred microliters of membrane suspension (50 pg protein) was incubated with 20 pi fo PK. 11195 (specific activity: 83.7 Ci/mmol, NEN.…”

Section: Methodsmentioning

confidence: 99%

Changes in Peripheral Benzodiazepine Receptors in Patients with Panic Disorder and Obsessive-Compulsive Disorder

Marazziti¹,

Rotondo²,

Martini

et al. 1994

Neuropsychobiology

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Peripheral benzodiazepine (BDZ) receptors were investigated through the binding of the specific ligand ³H-PK-11195 to platelet membranes, in 17 patients suffering from panic disorder (PD) and in 16 patients affected by obsessive-compulsive disorder (OCD). The results, showing that the density (Bmax) of peripheral BDZ receptors was significantly lower in patients with PD than in controls or OC patients, suggest that the number of platelet BDZ receptors varies with different anxiety disorders and that perhaps this marker may be beneficial in differentiating some subtypes of these disorders.

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Decreased peripheral benzodiazepine binding sites in platelets of neuroleptic-treated schizophrenics

Cited by 56 publications

References 25 publications

Effect of Increasing Estradiol Levels on Platelet Peripheral Benzodiazepine Binding Sites in Women Undergoing Human Menopausal Gonadotropin Treatment

Effect of Increasing Estradiol Levels on Platelet Peripheral Benzodiazepine Binding Sites in Women Undergoing Human Menopausal Gonadotropin Treatment

Effect of chronic haloperidol treatment on peripheral benzodiazepine binding sites in cerebral cortex of rats

Changes in Peripheral Benzodiazepine Receptors in Patients with Panic Disorder and Obsessive-Compulsive Disorder

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