Decreased photosensitivity to <scp>UVA</scp> on vemurafenib combined with cobimetinib

Frénard, C.; Dutartre, H.; Boisrobert, Aurélie; Khammari, Amir; Dréno, Brigitte

doi:10.1111/jdv.15239

Cited by 1 publication

(1 citation statement)

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“…Systemic drug photosensitivity presents mainly as exaggerated sunburn or acute eczema on sun-exposed areas, but also as urticaria, lichenoid reactions, melanoma induces immediate burning upon sun-exposure followed by well-limited painful edema and erythema that persist for a few days occurs in 22-66% of patients 8,36 , but this reaction is less frequent when vemurafenib is associated with a MEK inhibitor 37 . A similar pattern has also been described with other BRAF inhibitors and other targeted therapies for cancer, namely the anaplastic lymphoma kinase (ALK) inhibitor brigatinib (Fig.…”

Section: Clinical Presentations Of Drug Photosensitivitymentioning

confidence: 99%

Drug-induced photosensitivity

Gouveia

Gameiro

Coutinho

et al. 2023

PJDV

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Drug photosensitivity is a relatively frequent adverse event, although not always recognized due to its clinical polymorphism and difficulties in performing tests to prove drug causality.The aim of this report is to review the mechanisms of photosensitivity related with topical and systemic drugs (phototoxicity, photoallergy, autoimmunity, and enhanced photocarcinogenesis), the main acute and delayed clinical manifestations (acute sunburn or eczema, pseudoporphyria, photo-onycholysis, dyschromia, telangiectasia, subacute lupus erythematosus, pre-cancerous lesions, and cutaneous neoplasia), the main culprits [non-steroidal anti-inflammatory drugs (NSAIDs), antimicrobials, like fluoroquinolones and tetracyclines, psychotropic, anticancer, and cardiovascular drugs] and the most adequate diagnostic procedures (photopatch and drug photoprovocation tests).

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Section: Clinical Presentations Of Drug Photosensitivitymentioning

confidence: 99%