Decreased plasma concentrations of adiponectin in patients with slow coronary flow

Abstract

Adiponectin has multiple protective effects on vascular endothelium through anti-inflammatory and anti-atherogenic properties. Recent data suggested that endothelial activation and inflammation may contribute to the pathogenesis of slow coronary flow (SCF). Therefore, we investigated whether adiponectin plasma concentrations were decreased in patients with SCF compared to subjects with normal coronary flow. The study population consisted of 35 patients with angiographically documented SCF in all three coronary arteries and 35 sex- and age-matched cases with normal coronary flow. Coronary flow rates of all participants were determined by Thrombolysis in Myocardial Infarction (TIMI) frame count. Plasma adiponectin concentrations were measured by an enzyme-linked immunosorbent assay method using commercially available adiponectin kits. There were no statistically significant differences between the patients with SCF and the subjects with normal coronary flow in terms of demographic characteristics and cardiovascular risk factors (P>0.05). Plasma adiponectin concentrations of patients with SCF were found to be significantly lower than those with normal coronary flow (4.77+/-3.86 mg/ml vs 10.8+/-6.60 mg/ml, P=0.001, respectively). Plasma adiponectin levels were correlated significantly and inversely with mean TIMI frame count in patients with SCF (r= -0.441, P=0.008). Furthermore, the Receiver Operator Characteristics curve of adiponectin concentrations showed that an adiponectin <4.6 mg/ml is associated with SCF with a sensitivity of 68.6%, specificity of 82.9%, positive predictive value of 80.0%, and negative predictive value of 72.5%. Our findings suggest that endothelial inflammation may play a role in the pathogenesis of SCF phenomenon.

Documentation of Impaired Coronary Blood Flow in Chronic Obstructive Pulmonary Disease Patients

“…26,33,34 In COPD presence of endothelial dysfunction was also demonstrated. 35 Therefore, endothelial dysfunction might represent another link between COPD and SCF, whether it was initiated by smoking, inflammation or COPD itself.…”

Association of sleep apnea with coronary slow-flow phenomenon

“…[23][24][25][26][27][28][29][30][31][32][33][34][35] In addition to these similarities, obesity with or without insulin resistance and lower concentrations of adiponectin and leptin, a hormone involved in the control of body weight and sympathetic nerve activity, have also been found more frequently in both CSFP and OSA. 36 Relationship between the severity of apnea-hypopnea index (AHI) and mean TIMI frame count (TFC).…”

Decreased risk of ventricular arrhythmias with treatment of nebivolol in patients with coronary slow flow

“…Different theories have been postulated about the cause of small vessel dysfunction based on observations including microvascular tone dysfunction, endothelial thickening in small vessels [8], patchy fibrosis in the biopsy specimen taken from the right ventricle [9], impaired endothelial release of nitric oxide [10], and endothelial inflammation [11].…”