2003
DOI: 10.1097/00003086-200303000-00043
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Decreased Platelet Derived Growth Factor Expression During Fracture Healing in Diabetic Animals

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Cited by 78 publications
(64 citation statements)
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“…Evidence exists that some of the influences of diabetes on fracture repair are related to the inhibition of growth factors, although the underlying mechanism is largely unknown. It has been postulated that in diabetes there is reduced cell proliferation in the early phase of fracture healing as a result of decreased expression of platelet-derived growth factor [46]. The levels of TGF-β1 and other growth factors (IGF-1, VEGF) have also been shown to be significantly reduced in diabetic animals [47].…”
Section: Discussionmentioning
confidence: 99%
“…Evidence exists that some of the influences of diabetes on fracture repair are related to the inhibition of growth factors, although the underlying mechanism is largely unknown. It has been postulated that in diabetes there is reduced cell proliferation in the early phase of fracture healing as a result of decreased expression of platelet-derived growth factor [46]. The levels of TGF-β1 and other growth factors (IGF-1, VEGF) have also been shown to be significantly reduced in diabetic animals [47].…”
Section: Discussionmentioning
confidence: 99%
“…8,31,32 PDGF and bFGF are potent mitogens and have been reported to enhance the release of additional signaling factors from mesenchymal cells that are involved in chondrogenesis and bone formation. 33 Other diabetic fracture healing studies have shown that reduced expression of critical transcription factors correlated with impaired bone healing.…”
Section: Fracture Healing In a Diabetic Rat Modelmentioning
confidence: 99%
“…Impairment of histomorphometric, cellular, and biochemical indicators of bone formation, like osteocalcin have been linked to diabetes mellitus [15,27,32]. One study suggests delayed fracture healing in an animal model of diabetes is attributable in part to reduced cellular proliferation associated with decreased levels of platelet-derived growth factor (PDGF) [31]. Thus, it is possible biologic interventions capable of stimulating cellular proliferation and osteogenesis may promote fracture healing in patients with diabetes.…”
Section: Introductionmentioning
confidence: 99%