Decreased prealbumin level is associated with increased risk for mortality in elderly hospitalized patients with COVID-19

Zuo, Peiyuan; Song, Tie; Yan, Qi; Cheng, Ling Jie; Li, Yuanyuan; Song, Kaixin; Chen, Yuting; Dai, Yue; Gao, Hongyu; Zhang, Cuntai

doi:10.1016/j.nut.2020.110930

Cited by 26 publications

(28 citation statements)

References 19 publications

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“…The range of the sample sizes of the selected studies was 17 to 446. Five studies were conducted in Europe (C. Annweiler et al, 2020 ; G. Annweiler et al, 2020 ; Bedock et al, 2020 ; Moghaddam et al, 2020 ; Recinella et al, 2020 ), and three in Asia ( Rehman et al, 2020 ; Tan et al, 2020 ; Zuo et al, 2020 ). The diagnosis of older people for COVID-19 was done using two techniques: real-time PCR test (C. Annweiler et al, 2020 ; G. Annweiler et al, 2020 ; Bedock et al, 2020 ; Moghaddam et al, 2020 ; Recinella et al, 2020 ; Rehman et al, 2020 ; Tan et al, 2020 ; Zuo et al, 2020 ) and chest CT scans (C. Annweiler et al, 2020 ; Bedock et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…Studies with various study designs were included in this review and assessed accordingly with the quality assessment tools of the National Heart, Lung, and Blood Institute of the National Institutes of Health ( Table 2 ). The majority of the studies (C. Annweiler et al, 2020 ; G. Annweiler et al, 2020 ; Bedock et al, 2020 ; Li et al, 2020 ; Moghaddam et al, 2020 ; Tan et al, 2020 ; Zuo et al, 2020 ) were rated ‘fair’. Only two studies ( Recinella et al, 2020 ) rated ‘good’ in the quality assessment.…”

Section: Resultsmentioning

confidence: 99%

“…Various different COVID-19 related outcomes were identified in the selected studies. Transfer to intensive care unit (ICU) or death ( Bedock et al, 2020 ), malnutrition itself ( Rehman et al, 2020 ), hospital deaths, PaO2/FiO2 ratio (ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen)( Recinella et al, 2020 ), oxygen therapy and/or intensive care support ( Tan et al, 2020 ), ICU admission and mechanical ventilation ( Zuo et al, 2020 ), time to discharge or death ( Moghaddam et al, 2020 ), COVID-19 mortality and Ordinal Scale for Clinical Improvement (OSCI) score in acute phase (C. Annweiler et al, 2020 ), and 14-day mortality and highest (worst) score OSCI measured during COVID-19 acute phase (G. Annweiler et al, 2020 ). The details of these outcomes are presented in Tables 3 and 4 .…”

Section: Resultsmentioning

confidence: 99%

“…Three studies provided data on nutritional status and COVID-19 outcomes ( Tan et al (2020) , Zuo et al (2020) , Moghaddam et al (2020) . Among the three studies that considered nutritional status, Recinella et al (2020) assessed nutritional status by GNRI.…”

Section: Resultsmentioning

confidence: 99%

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Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: A systematic review

Damayanthi

Prabani

2021

Archives of Gerontology and Geriatrics

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: A systematic review

Damayanthi

Prabani

2021

Archives of Gerontology and Geriatrics

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“…Several studies have focused on biomedical analysis of COVID-19 for older patients in order to investigate clinical characteristics of those with COVID-19 (e.g. Liu et al 2020a, b;Wang et al 2020a, b;Zuo et al 2020;Niu et al 2020;Guo et al 2020). Studies have also explored the potential consequences of social distancing on elder well-being, emphasizing the indirect detrimental impacts of COVID-19 and the need to address them (e.g.…”

Section: Introductionmentioning

confidence: 99%

A preliminary exploration of attitudes about COVID-19 among a group of older people in Iwate Prefecture, Japan

Traphagan

2021

J Cross Cult Gerontol

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In this article, our goal is to provide researchers with a non-western perspective concerning the COVID-19 pandemic through a qualitative study of older adults living in Iwate, a prefecture in Japan that has only recently (27 July 2020) reported its first confirmed COVID-19 cases and which has experienced comparatively few cases since. Because they live in an environment with few COVID-19 cases, the individuals in this study provide an interesting perspective of the pandemic as it is unfolding in rural Japan and our focus here is on documenting the circumstances and ideas of elder residents of Iwate Prefecture to understand individual experiences of this population. Our intention here is to provide data and tentative analysis that may be useful in developing more complex cross-cultural studies related to the lived experience of COVID-19 among older people.

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The accelerated organ senescence and proteotoxicity in thyrotoxicosis mice

Feng,

Xia,

Feng

et al. 2023

Journal Cellular Physiology

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The mechanism of aging has always been the focus of research, because aging is related to disease susceptibility and seriously affects people's quality of life. The diseases also accelerate the aging process, especially the pathological changes of substantive organs, such as cardiac hypertrophy, severely shortened lifespan. So, lesions in organs are both a consequence and a cause of aging. However, the disease in a given organ is not in isolation but is a systemic problem. Our previous study found that thyrotoxicosis mice model has aging characteristics including immunosenescence, lipotoxicity, malnutrition. But all these characteristics will lead to organ senescence, therefore, this study continued to study the aging changes of important organs such as heart, liver, and kidney in thyrotoxicosis mice using tandem mass tags (TMT) proteomics method. The results showed that the excess thyroxine led to cardiac hypertrophy. In the liver, the ability to synthesize functional proteins, detoxify, and metabolism were declined. The effect on the kidney was the decreased ability of detoxify and metabolism. The main finding of the present study was that the acceleration of organ senescence by excess thyroxine was due to proteotoxicity. The shared cause of proteotoxicity in the three organs included the intensify of oxidative phosphorylation, the redundancy production of ribosomes, and the lack of splicing and ubiquitin proteasome system function. Totally, proteotoxicity was another parallel between thyrotoxicosis and aging in addition to lipotoxicity. Our research provided a convenient and appropriate animal model for exploring aging mechanism and antiaging drugs.

show abstract

Decreased prealbumin level is associated with increased risk for mortality in elderly hospitalized patients with COVID-19

Cited by 26 publications

References 19 publications

Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: A systematic review

Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: A systematic review

A preliminary exploration of attitudes about COVID-19 among a group of older people in Iwate Prefecture, Japan

The accelerated organ senescence and proteotoxicity in thyrotoxicosis mice

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