Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Witt, Suzanne T.; Lovejoy, David W.; Pearlson, Godfrey D.; Stevens, Michael C.

doi:10.1007/s11682-010-9102-3

Cited by 79 publications

(81 citation statements)

References 106 publications

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“…The network of temporoparietal, temporal, cerebellar, thalamic and frontal regions shown to be associated with task performance is consistent with similar oddball-type selective attention tasks studied previously (Kiehl and Liddle, 2001; Kiehl et al, 2005; Linden et al, 1999; Witt et al, 2010; Wolf et al, 2008). Also consistent with previous studies of oddball tasks, the temporoparietal junction showed the strongest response during the task in silence in healthy subjects.…”

Section: Discussionsupporting

confidence: 87%

The effect of distracting noise on the neuronal mechanisms of attention in schizophrenia

Tregellas

Smucny

Eichman

et al. 2012

Schizophrenia Research

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Objective-The inability to ignore irrelevant environmental noise is a common problem for people with schizophrenia. The purpose of this study was to determine if the neuronal response to distracting noise is related to mechanisms of altered attention observed in the illness.Method-Twenty-two outpatients with schizophrenia and seventeen healthy comparison subjects performed a selective attention task in the presence or absence of distracting environmental noise while undergoing functional magnetic resonance imaging at 3T. A separate condition examining passive response to the distracting noise also was included.Results-Group differences in neuronal response during the attention task were magnified by distracting noise, with the greatest difference being less response by patients, relative to comparison subjects, in the temporoparietal junction. Separate passive listening to distracting noise resulted in greater hippocampal response in patients, relative to comparison subjects. Across all subjects, hippocampal response to noise was inversely related to the degree to which the attention-task-related network was up-regulated to perform the task during distracting noise.Conclusions-Given the observed hippocampal hyperactivity in response to environmental noise in patients and the inverse relationship between hippocampal response to noise and the effects of noise on the task-related network, hippocampal hyperactivity may contribute to impaired recruitment of attention networks in schizophrenia.

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Section: Discussionsupporting

confidence: 87%

The effect of distracting noise on the neuronal mechanisms of attention in schizophrenia

Tregellas

Smucny

Eichman

et al. 2012

Schizophrenia Research

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“…55,57,58 Further, reduced functional connectivity in concussed persons has been observed during attention and working memory paradigms. 80,81 In addition, recent functional magnetic resonance imaging 82 demonstrated activation deficits during performance of an oddball task in the dorsolateral prefrontal cortex and superior parietal lobe in formerly concussed persons. Hence, concussive injuries may disrupt the structural or functional integrity of areas responsible for P3 generation.…”

Section: Discussionmentioning

confidence: 99%

The Persistent Influence of Concussive Injuries on Cognitive Control and Neuroelectric Function

Moore

Hillman

Broglio

2014

Journal of Athletic Training

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Context: Increasing attention is being paid to the deleterious effects of sport-related concussion on cognitive and brain health.Objective: To evaluate the influence of concussion incurred during early life on the cognitive control and neuroelectric function of young adults.Design: Cross-sectional study. Setting: Research laboratory.Patients or Other Participants: Forty young adults were separated into groups according to concussive history (0 or 1þ). Participants incurred all injuries during sport and recreation before the age of 18 years and were an average of 7.1 6 4.0 years from injury at the time of the study.Intervention(s): All participants completed a 3-stimulus oddball task, a numeric switch task, and a modified flanker task during which event-related potentials and behavioral measures were collected.Main Outcome Measure(s): Reaction time, response accuracy, and electroencephalographic activity.Results: Compared with control participants, the concussion group exhibited decreased P3 amplitude during target detection within the oddball task and during the heterogeneous condition of the switch task. The concussion group also displayed increased N2 amplitude during the heterogeneous version of the switch task. Concussion history was associated with response accuracy during the flanker task.Conclusions: People with a history of concussion may demonstrate persistent decrements in neurocognitive function, as evidenced by decreased response accuracy, deficits in the allocation of attentional resources, and increased stimulusresponse conflict during tasks requiring variable amounts of cognitive control. Neuroelectric measures of cognitive control may be uniquely sensitive to the persistent and selective decrements of concussion.Key Words: concussions, inhibition, mental flexibility, attention, P3, N2 Key PointsSeven years after concussion, participants displayed disrupted higher-order neurocognition in the form of chronically impaired attention, working memory, inhibition, and interference control. The observed deficits in attention and conflict monitoring were only evident when cognitive demands were increased. Subtle deficits may remain unrecognized with other types of testing.

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“…In contrast, Talavage and colleagues (2010) reported hypoactivation in concussed adolescent football players within the left middle and superior temporal gyri, left middle occipital gyrus, and bilateral cerebellum, during an N-back working memory task. Similarly, adult fMRI studies of semi-acute mTBI have also reported a mixture of both hypoactivation (Mayer et al, 2009;McAllister et al, 1999McAllister et al, ,2001Witt et al, 2010), and hyperactivation (McAllister et al, 1999(McAllister et al, ,2001Slobounov et al, 2010;Smits et al, 2009), during a variety of different cognitive challenges.…”

Section: Introductionmentioning

confidence: 93%

An fMRI Study of Auditory Orienting and Inhibition of Return in Pediatric Mild Traumatic Brain Injury

Yang

Yeo

Peña

et al. 2012

Journal of Neurotrauma

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Studies in adult mild traumatic brain injury (mTBI) have shown that two key measures of attention, spatial reorienting and inhibition of return (IOR), are impaired during the first few weeks of injury. However, it is currently unknown whether similar deficits exist following pediatric mTBI. The current study used functional magnetic resonance imaging (fMRI) to investigate the effects of semi-acute mTBI ( < 3 weeks post-injury) on auditory orienting in 14 pediatric mTBI patients (age 13.50 -1.83 years; education: 6.86 -1.88 years), and 14 healthy controls (age 13.29 -2.09 years; education: 7.21 -2.08 years), matched for age and years of education. The results indicated that patients with mTBI showed subtle (i.e., moderate effect sizes) but non-significant deficits on formal neuropsychological testing and during IOR. In contrast, functional imaging results indicated that patients with mTBI demonstrated significantly decreased activation within the bilateral posterior cingulate gyrus, thalamus, basal ganglia, midbrain nuclei, and cerebellum. The spatial topography of hypoactivation was very similar to our previous study in adults, suggesting that subcortical structures may be particularly affected by the initial biomechanical forces in mTBI. Current results also suggest that fMRI may be a more sensitive tool for identifying semi-acute effects of mTBI than the procedures currently used in clinical practice, such as neuropsychological testing and structural scans. fMRI findings could potentially serve as a biomarker for measuring the subtle injury caused by mTBI, and documenting the course of recovery.

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Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Cited by 79 publications

References 106 publications

The effect of distracting noise on the neuronal mechanisms of attention in schizophrenia

The effect of distracting noise on the neuronal mechanisms of attention in schizophrenia

The Persistent Influence of Concussive Injuries on Cognitive Control and Neuroelectric Function

An fMRI Study of Auditory Orienting and Inhibition of Return in Pediatric Mild Traumatic Brain Injury

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