Decreased production of inflammatory cytokines by circulating monocytes and dendritic cells in type 2 diabetic men with atherosclerotic complications

Persistence of androgenic effects on the production of proinflammatory cytokines by circulating antigen-presenting cells after withdrawal of testosterone treatment in aging type 2 diabetic men with partial androgen deficiency

“…In this regard, in a previous work from our group including 55 type 2 diabetic men (most without androgen deficiency), we could not detect significant differences between both groups of individuals with respect to various numeric and functional features of PB DC (46).…”

Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation

“…However, Van Brussel et al (2011) showed that pDCs derived from CAD patients expressed lower levels of CD83 and TLR7 and as a consequence produced less IFN-α. Similarly, decreased expression of proinflammatory cytokines (IL-1β and IL-6) was observed in type 2 diabetic patients with atherosclerotic complications (Corrales et al, 2007). This may suggest for impaired function of atherosclerotic pDCs that become more resistant to multiple proinflammatory stimuli present in the plaque.…”

Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial

“…Both TNF-a and IL-6, the Pro-inflammatory cytokines, increase in diabetic condition and have important role in development of diabetes and cardiovascular complications (Herder et al, 2011). Studies have indicated a therapeutic approach for decrease of these cytokine levels may attenuate the progression of diabetes complications (Corrales et al, 2007). So even, effects of BSP on minor reduction of TNF-a and IL-6 levels may be useful in prevention of consequent cardiovascular events.…”