Decreased regional gray matter volume in suicide attempters compared to suicide non-attempters with major depressive disorders

Lee, Yu Jin; Kim, Soohyun; Gwak, Ah Reum; Kim, Seog Ju; Kang, Seung-Gul; Lee, Jin-Seong; Son, Young-Don; Park, Juhyun

doi:10.1016/j.comppsych.2016.02.013

Cited by 72 publications

(39 citation statements)

References 40 publications

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“…In addition, the hippocampus and the angular gyrus are the biological markers for MDD, but little is known about the relationship between the volume of these regions and suicide attempters. An interesting finding reported that suicide attempters have reduced gray matter volume in the hippocampus and in the left angular gyrus, especially in cases of acute suicide. It was also found that the total volume of the hippocampal threshold of 5 cm 3 had a negative predictive value of 98.2% for acute suicide attempts .…”

Section: Impaired Circuits In Mddmentioning

confidence: 99%

“…Abnormalities in the fiber connections passing through the left anterior limb of the internal capsule that projects to the left middle frontal cortex and the OFC and finally posteriorly to the left thalamus in MDD patients who committed suicide were found to be more severe than those who did not commit suicide and controls. The middle frontal cortex and the OFC are related to decision making and problem solving and can affect modulation, and the thalamus is involved in the mood‐related neural network . These three regions are considered hub nodes of brain connections .…”

Section: Impaired Circuits In Mddmentioning

confidence: 99%

“…It was also found that the total volume of the hippocampal threshold of 5 cm 3 had a negative predictive value of 98.2% for acute suicide attempts . The angular gyrus is known to be part of the default‐mode network, and impairments in this region in patients are associated with negative thoughts about the future or themselves . Disruptions in the angular gyrus may lead to suicidal behaviors or may increase the risk of suicide.…”

Section: Impaired Circuits In Mddmentioning

confidence: 99%

“…tempters. An interesting finding reported that suicide attempters have reduced gray matter volume in the hippocampus 104 and in the left angular gyrus, 98 especially in cases of acute suicide. It was also found that the total volume of the hippocampal threshold of 5 cm 3 had a negative predictive value of 98.2% for acute suicide attempts.…”

Section: Frontothalamic Circuitmentioning

confidence: 99%

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Brain structure alterations in depression: Psychoradiological evidence

et al. 2018

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Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made based on clinical manifestations, with little objective evidence. Magnetic resonance imaging (MRI) has been used to investigate the pathological changes in brain anatomy associated with this disorder. MRI can identify structural alterations in depressive patients in vivo, which could make considerable contributions to clinical diagnosis and treatment. Numerous studies that focused on gray and white matter have found significant brain region alterations in major depressive disorder patients, such as in the frontal lobe, hippocampus, temporal lobe, thalamus, striatum, and amygdala. The results are inconsistent and controversial because of the different demographic and clinical characteristics. However, some regions overlapped; thus, we think that there may be a "hub" in MDD and that an impairment in these regions contributes to disease severity. Brain connections contain both structural connections and functional connections, which reflect disease from a different view and support that MDD may be caused by the interaction of multiple brain regions. According to previous reports, significant circuits include the frontal-subcortical circuit, the suicide circuit, and the reward circuit. As has been recognized, the pathophysiology of major depressive disorder is complex and changeable. The current review focuses on the significant alterations in the gray and white matter of patients with the depressive disorder to generate a better understanding of the circuits. Moreover, identifying the nuances of depressive disorder and finding a biomarker will make a significant contribution to the guidance of clinical diagnosis and treatment.

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Section: Impaired Circuits In Mddmentioning

confidence: 99%

Section: Impaired Circuits In Mddmentioning

confidence: 99%

Section: Impaired Circuits In Mddmentioning

confidence: 99%

Section: Frontothalamic Circuitmentioning

confidence: 99%

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Brain structure alterations in depression: Psychoradiological evidence

et al. 2018

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“…The cerebellum is increasingly recognized for its involvement in emotional processes [147,148]. Lower volumes of the cerebellum were reported in adult and adolescent SAs with MDD or BD [35,69,145,149]. Functionally, while adult SAs with MDD showed increased cerebellum activation during recall and reimagination of their own suicidal episode [71] and while viewing angry faces, they showed decreased activation while viewing happy faces [47].…”

Section: Posterior Structuresmentioning

confidence: 99%

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide.

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Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder

Overs

Roberts

Ridgway

et al. 2021

American J of Med Genetics Pt B

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Bipolar disorder (BD) is associated with a 20-30-fold increased suicide risk compared to the general population. First-degree relatives of BD patients show inflated rates of psychopathology including suicidal behaviors. As reliable biomarkers of suicide attempts (SA) are lacking, we examined associations between suicide-related polygenic risk scores (PRSs)-a quantitative index of genomic risk-and variability in brain structures implicated in SA. Participants (n = 206; aged 12-30 years) were unrelated individuals of European ancestry and comprised three groups: 41 BD cases, 96 BD relatives ("high risk"), and 69 controls. Genotyping employed PsychArray, followed by imputation. Three PRSs were computed using genome-wide association data for SA in BD (SA-in-BD), SA in major depressive disorder (SA-in-MDD) (Mullins et al.,

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Decreased regional gray matter volume in suicide attempters compared to suicide non-attempters with major depressive disorders

Cited by 72 publications

References 40 publications

Brain structure alterations in depression: Psychoradiological evidence

Brain structure alterations in depression: Psychoradiological evidence

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder

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