Decreased resistance to intravenous tumour-cell challenge during reticuloendothelial depression following surgery1

Saba, Thomas M.; Antikatzides, T G

doi:10.1038/bjc.1976.181

Cited by 51 publications

(25 citation statements)

References 17 publications

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“…Lymphoid cells obtained from rats subjected to bums or surgical injury are unable to manifest graft-vs.-host reactions in recipient rats differing at a minor histocompatibility locus (22). The incidence of tumor take (23,24) and spontaneous metastases (25) is increased when tumorinjected animals are subjected to surgical operations. The number of T lymphocytes is significantly decreased after burns as measured by rosette formation with sheep erythrocytes (26).…”

Section: Resultsmentioning

confidence: 99%

Generation of suppressor cells in mice after surgical trauma.

Wang¹,

Heacock²,

Wu³

et al. 1980

J. Clin. Invest.

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A B S T R A C T Immunoincompetency is often seen in patients after various types of trauma and is associated with increased morbidity and mortality from infectious complications. To understand better the immunologic impairment associated with trauma, we have studied this phenomenon in an animal model. Splenocytes from mice traumatized by amputation of their right hind limbs were consistently shown to have a diminished capacity to proliferate in response to alloantigens and to form alloreactive cytolytic cells in mixed lymphocyte cultures. Anesthesia itself had no effect in this system. The immunoincompetency was detected from 2 h to 6 d after surgical trauma and was completely reversed by removing adherent and phagocytic cells from the splenocytes. Furthermore, addition of splenocytes from traumatized mice to mixed lymphocyte cuiltures from normal mice prevented normal lymphocytes from responding to alloantigens, suggesting the existence of suppressor cells. The suppressor cells were found to adhere to glass and to nylon wool columns, and were contained within an esterase-positive cell population. They were insensitive to treatment with anti-Thy 1.2 and anti-Ig sera in the presence of complement. Therefore, the present results suggest that a Thy 1.2-negative, Ig-negative, esterase-positive cell population capable of adhering to glass and nylon wool, presumably macrophages, was responsible for the inhibition of the responsiveness of lymphocytes to alloantigens in traumatized animals.

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Section: Resultsmentioning

confidence: 99%

Generation of suppressor cells in mice after surgical trauma.

Wang¹,

Heacock²,

Wu³

et al. 1980

J. Clin. Invest.

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“…It has been shown that after an operation there is a reduction of T-cell function as measured by leucocyte migration (Cochran et al, 1972), leucocyte cytotoxicity (Vose and Moudgil, 1975) and phytohaemagglutinin-induced lymphocyte transformation (Riddle, 1967). Operative stress is also associated with impairment of B-cell function, as measured by pokeweed mitogen and streptolysin stimulation (Jubert et al, 1973) and macrophage inhibition, measured as the reduced uptake of 131I-labelled lipid emulsion and 51Cr-labelled Walker 256 tumour cells by hepatic Kupifer cells (Saba and Antikatzides, 1976). The depression of macrophages may be due to the consumption of a glycoprotein, at the site of trauma, which is opsonic for Kupffer-cell phagocytic activity (Saba and Scovill, 1975).…”

Section: Discussionmentioning

confidence: 99%

“…TUMOUR growth is enhanced by operation (Buinauskas et al, 1965) possibly due in part to depression of both the macrophage system (Saba and Antikatzides, 1976) and T-lymphocyte function (Cochran et al, 1972;Vose and Moudgil, 1975).…”

mentioning

confidence: 99%

Effects of amputation and Corynebacterium parvum on tumour metastases in mice

Mosley¹,

Sadler²,

Castro³

1978

Br J Cancer

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Summary. The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated.Anaesthesia alone or with amputation did not affect primary tumour growth. C. parvum depressed this growth.Anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. C. parvum inhibited metastases and completely counteracted the effects of operation on them. Large doses of cortisone acetate significantly increased metastases but small doses had no effect. Experiments with adrenalectomized mice suggested the effects of operation were due to non-specific stress.

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“…Non-specific stimulation of the reticuloendothelial system (RES) enhances host resistance to tumour growth and tumourcell dissemination (Stern, 1960;Old et al, 1961;Hanna, Zbar and Rapp, 1972) while macrophage dysfunction has been correlated with impaired anti-tumour immunity (Kampschmidt and Clabaugh, 1964;Saba and Antikatzides, 1976). The neoplastic process itself has a deleterious effect on RES function (Franchi et al, 1972;Di Luzio, 1975;Saba and Antikatzides, 1975) clearly indicating that the suppression of the macrophage, or inability of the macrophage to become activated, may be a critical event in the dissemination and proliferation of neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

“…For example, pulmonary metastatic tumour growth from i.v. injected tumour cells can be enhanced by local X-irradiation of the lung (van den Brenk et al, 1973; surgically induced hepatic RE depression (Saba and Antikatzides, 1976;van den Brenk et al, 1976) pharmacologically induced pulmonary inflammatory reactions or i.v. injection of potent cytostatic agents such as cyclophosphamide (van Putten et al, 1975;Carmel and Brown, 1977).…”

Section: Discussionmentioning

confidence: 99%