Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation

Abstract

Cognitive abilities are impaired by sleep deprivation and can be recovered when sufficient sleep is obtained. Changes in alpha-band oscillations are considered to be closely related to sleep deprivation. In this study, power spectrum, source localization and functional connectivity analyses were used to investigate the changes in resting-state alpha-band activity after normal sleep, sleep deprivation and recovery sleep. The results showed that the global alpha power spectrum decreased and source activation was notably reduced in the precuneus, posterior cingulate cortex, cingulate gyrus, and paracentral lobule after sleep deprivation. Functional connectivity analysis after sleep deprivation showed a weakened functional connectivity pattern in a widespread network with the precuneus and posterior cingulate cortex as the key nodes. Furthermore, the changes caused by sleep deprivation were reversed to a certain extent but not significantly after one night of sleep recovery, which may be due to inadequate time for recovery sleep. In conclusion, large-scale resting-state alpha-band activation and functional connectivity were weakened after sleep deprivation, and the inhibition of default mode network function with the precuneus and posterior cingulate cortex as the pivotal nodes may be an important cause of cognitive impairment. These findings provide new insight into the physiological response to sleep deprivation and determine how sleep deprivation disrupts brain alpha-band oscillations.

Resting-state functional connectivity of the sensory/somatomotor network associated with sleep quality: evidence from 202 young male samples

“…Results found that the left putamen had decreased FC in the bilateral PreCG and bilateral PoCG compared to individuals after sleep deprivation in the normal wakefulness state. At the same time, Wu et al ( 2021 ) analyzed resting state alpha-band EEG and found that male sleep deprivation significantly reduced the alpha lagged linear connectivity in most cortical areas, especially in PCUN and PCL. The PCUN and PCL belonged to the parietal lobe, which was involved in a variety of complex functions and was critical for somato-motor processing (Zhang et al, 2020a , b ).…”

Sleep deprivation results in diverse patterns of synaptic scaling across the Drosophila mushroom bodies

“…These findings parallel those from humans and rodents, suggesting that some measures of cognition and neurophysiology recover rapidly after acute sleep loss while others last much longer, even for several days in some cases. [92][93][94][95][96] The tractability of Drosophila may provide opportunities for future studies to investigate the processes that mediate recovery from sleep loss and to test whether similar trends in plasticity occur in other neuropil regions across the brain. Interestingly, sleep deprivation does not seem to increase other active zone components; Rim and Syt1 only show localized changes in some MB lobes, and the primarily post-synaptic marker Dlg shows no significant changes across the MB after sleep loss.…”

Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study

“…Before the experiment, all participants practiced the two types of WMU tasks until they reached an accuracy of 90%. The following day, the participants completed two WMU tasks with simultaneous EEG recordings (baseline) from 7:30 to 8:30 a.m. ( Wu et al, 2021 ). After 36 h of TSD, from 7:30 to 8:30 p.m. the next day ( Wu et al, 2021 ), they completed similar WMU tasks with the second simultaneous EEG recording (TSD).…”

“…The following day, the participants completed two WMU tasks with simultaneous EEG recordings (baseline) from 7:30 to 8:30 a.m. ( Wu et al, 2021 ). After 36 h of TSD, from 7:30 to 8:30 p.m. the next day ( Wu et al, 2021 ), they completed similar WMU tasks with the second simultaneous EEG recording (TSD). The participants were instructed to stay awake throughout the TSD period, and were prohibited from taking concentrated inhibitory or irritating drugs during the entire experiment.…”