Decreased Resting-State Functional Connectivity of Periaqueductal Gray in Temporal Lobe Epilepsy Comorbid With Migraine

Wang, Long; Cai, Xinting; Zu, Meidan; Zhang, Juan; Deng, Zi‐Ru; Wang, Yu

doi:10.3389/fneur.2021.636202

Cited by 4 publications

(4 citation statements)

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“… 48 , 49 Past studies noted that impaired DPMS and treatment modulation, using vlPAG as the seed for rs‐FC, in patients having chronic pain disorders. 40 , 50 , 51 , 52 , 53 , 54 , 55 , 56 These results indicated that it is possible to evaluate the DPMS and the modulation effects of treatment in KOA knee pain individuals by utilizing vlPAG rs‐FC in a non‐invasive manner.…”

Section: Introductionmentioning

confidence: 84%

“…Furthermore, prior research demonstrated that central sensitization and increased vlPAG activity in osteoarthritis patients are associated with skin irritation in pain areas 48,49 . Past studies noted that impaired DPMS and treatment modulation, using vlPAG as the seed for rs‐FC, in patients having chronic pain disorders 40,50–56 . These results indicated that it is possible to evaluate the DPMS and the modulation effects of treatment in KOA knee pain individuals by utilizing vlPAG rs‐FC in a non‐invasive manner.…”

Section: Introductionmentioning

confidence: 96%

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Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients

et al. 2023

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Background The analgesic effect of acupuncture is widely recognized, but the mechanical characteristics of acupuncture for pain relief, compared to non‐steroidal anti‐inflammatory (NSAIDs) and placebo medication, remain unknown. Aims To compare the modulation effects of acupuncture treatment with NSAIDs and placebo medication on descending pain modulation system (DPMS) in knee osteoarthritis (KOA) patients. Methods This study recruited 180 KOA patients with knee pain and 41 healthy controls (HCs). Individuals with KOA knee pain were divided randomly into groups of verum acupuncture (VA), sham acupuncture (SA), celecoxib (SC), placebo (PB), and waiting list (WT), with 36 patients in each group. VA and SA groups included ten sessions of puncturing acupoints or puncturing non‐acupoints acupuncture treatment for two successive weeks. Celecoxib capsules were continuously given orally to patients in the SC group at a dosage of 200 mg daily for 2 weeks. In the PB group, patients received a placebo capsule once a day for 2 weeks at the same dosage as celecoxib capsules. In the WL group, patients did not receive any treatment. Patients underwent a resting‐state BOLD‐fMRI scan pre‐ and post‐receiving the therapy, whereas HCs only underwent a baseline scan. Seed (ventrolateral periaqueductal gray, vlPAG, a key node in DPMS) based resting‐state functional connectivity (rs‐FC) was applied in the data analysis. Results All groups demonstrated improved knee pain scores relative to the initial state. There was no statistical difference between the VA and SA groups in all clinical outcomes, and vlPAG rs‐FC alterations. KOA knee pain individuals reported higher vlPAG rs‐FC in the bilateral thalamus than HCs. KOA knee pain patients in the acupuncture group (verum + sham, AG) exhibited increased vlPAG rs‐FC with the right dorsolateral prefrontal cortex (DLPFC) and the right angular, which is associated with knee pain improvement. In contrast with the SC and PB group, the AG exhibited significantly increased vlPAG rs‐FC with the right DLPFC and angular. Contrary to the WT group, the AG showed greater vlPAG rs‐FC with the right DLPFC and precuneus. Conclusions Acupuncture treatment, celecoxib, and placebo medication have different modulation effects on vlPAG DPMS in KOA knee pain patients. Acupuncture could modulate vlPAG rs‐FC with brain regions associated with cognitive control, attention, and reappraisal for knee pain relief in KOA patients, compared with celecoxib and placebo medication.

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Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 96%

Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients

et al. 2023

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“…However, few imaging studies have examined epilepsy with comorbid migraine. Wang et al [18] reported decreased functional connectivity between the periaqueductal gray (PAG) and pontine nucleus in temporal lobe epilepsy patients with comorbid migraine. Accordingly, which may be the potential imaging basis for the occurrence of temporal lobe epilepsy with comorbid migraine.…”

Section: Introductionmentioning

confidence: 99%

Structural brain characteristics of epilepsy patients with comorbid migraine without aura

Zhang,

Liu,

et al. 2023

Preprint

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Background Migraine is a common bi-directional comorbidity of epilepsy and there is possible potential complex interaction between the two diseases. Until now there is no study of brain morphology analysis of them. The use of VBM, SBM and SCN are helpful to improve the accuracy of detection of morphological changes. Methods Thirty patients of epilepsy with comorbid migraine without aura (EM) were included in our study, simultaneously, 20 healthy controls (HC), 30 epilepsy controls (EC) without migraine were recruited as control. We used voxel-based morphometry (VBM), surface-based morphometry (SBM), and structural covariance network (SCN) analysis to compare differences in gray matter volume, cortical thickness, and global level and local level graph theory indexes between the EM, EC, and HC groups to investigate structural brain changes in EM patients. Results VBM analysis showed that the EM group had gray matter atrophy in the right temporal pole compared with the HC group (p < 0.001, false discover rate correction). Furthermore, the headache duration in the EM group was negatively correlated with the gray matter volume of the right temporal pole (p < 0.05). SBM analysis showed cortical atrophy in the left insula, left posterior cingulate gyrus, left postcentral gyrus, left middle temporal gyrus, and left fusiform gyrus in EM compared with the HC group (p < 0.001, family wise error correction). We found a positive correlation between headache frequency and the cortical thickness of the left middle temporal gyrus (p < 0.05). SCN analysis revealed that no differences in global parameters between the three groups. The AUC of nodal betweenness centrality in the right postcentral gyrus was decreased in the EM group compared with the HC group (p < 0.001, FDR correction), and the AUC of the nodal degree in the right fusiform gyrus was decreased in the EM group compared with the EC group (p < 0.001, FDR correction). Conclusion We found clear structural brain changes in EM patients compared to HC. Migraine attacks may have potential effects on brain structure in epilepsy patients. Meanwhile, brain structural changes may be an important factor for the development of epilepsy with comorbid migraine. Further studies are needed to investigate the structural changes of epilepsy with comorbid migraine without aura.

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“…Resting-state functional MRI has detected reduced connectivity between PAG and the pedunculopontine nucleus in temporal lobe epilepsy comorbided with migraine. 77 And patients with occipitotemporal lobe epilepsy combined migraine with aura showed monogenic gene defect on chromosome 9q. 75 …”

Section: Introductionmentioning

confidence: 99%

Cortical mechanisms in migraine

et al. 2021

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Migraine is the second most prevalent disorder in the world; yet, its underlying mechanisms are still poorly understood. Cumulative studies have revealed pivotal roles of cerebral cortex in the initiation, propagation, and termination of migraine attacks as well as the interictal phase. Investigation of basic mechanisms of the cortex in migraine not only brings insight into the underlying pathophysiology but also provides the basis for designing novel treatments. We aim to summarize the current research literatures and give a brief overview of the cortex and its role in migraine, including the basic structure and function; structural, functional, and biochemical neuroimaging; migraine-related genes; and theories related to cortex in migraine pathophysiology. We propose that long-term plasticity of synaptic transmission in the cortex encodes migraine.

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Decreased Resting-State Functional Connectivity of Periaqueductal Gray in Temporal Lobe Epilepsy Comorbid With Migraine

Cited by 4 publications

References 80 publications

Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients

Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients

Structural brain characteristics of epilepsy patients with comorbid migraine without aura

Cortical mechanisms in migraine

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