Decreased risk of dementia in migraine patients with traditional Chinese medicine use: a population-based cohort study

Liu, Chun Ting; Wu, Bei; Hung, Yu Chiang; Wang, Lin Yi; Lee, Yan Yuh; Lin, Tay-Jyi; Lin, Pin‐Yao; Chen, Wu Fu; Chiang, Jen Huai; Hsu, Sheng Feng; Hu, Wen Long

doi:10.18632/oncotarget.19094

Cited by 18 publications

(14 citation statements)

References 45 publications

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“…[7] Notably, pretreatment with traditional Chinese medicine that exerts neuroprotective and antioxidant effects in patients with migraine significantly decreased the risk of dementia in patients aged 70 to 79 years, suggesting a causal relationship between migraine and dementia. [18]…”

Section: Discussionmentioning

confidence: 99%

Increased risk of neurodegenerative dementia in women with migraines

Lee

Lim

et al. 2019

Medicine

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Section: Discussionmentioning

confidence: 99%

Increased risk of neurodegenerative dementia in women with migraines

Lee

Lim

et al. 2019

Medicine

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“…Trikatu [ 51 ], a spice concoction made with black pepper, long pepper, and dried ginger has been advised to be of value against rheumatoid arthritis by Ayurveda, a classical traditional medicinal system from India. In Chinese traditional medicine, Xiaoyao-san , a combination of various spices, has been recommended for management of stress and depression-related disorders [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Data-driven analysis of biomedical literature suggests broad-spectrum benefits of culinary herbs and spices

et al. 2018

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Spices and herbs are key dietary ingredients used across cultures worldwide. Beyond their use as flavoring and coloring agents, the popularity of these aromatic plant products in culinary preparations has been attributed to their antimicrobial properties. Last few decades have witnessed an exponential growth of biomedical literature investigating the impact of spices and herbs on health, presenting an opportunity to mine for patterns from empirical evidence. Systematic investigation of empirical evidence to enumerate the health consequences of culinary herbs and spices can provide valuable insights into their therapeutic utility. We implemented a text mining protocol to assess the health impact of spices by assimilating, both, their positive and negative effects. We conclude that spices show broad-spectrum benevolence across a range of disease categories in contrast to negative effects that are comparatively narrow-spectrum. We also implement a strategy for disease-specific culinary recommendations of spices based on their therapeutic tradeoff against adverse effects. Further by integrating spice-phytochemical-disease associations, we identify bioactive spice phytochemicals potentially involved in their therapeutic effects. Our study provides a systems perspective on health effects of culinary spices and herbs with applications for dietary recommendations as well as identification of phytochemicals potentially involved in underlying molecular mechanisms.

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“…Strong REG signal for anti-migraine medicines was not accompanied by any tests for such in controlled trials. Instead in (Vuralli et al, 2018 in Table 2, [38], [39]), a mechanistic link between migraine and cognitive decline is discussed as under-appreciated. This leads to idea that anti-migraine medications may contribute to preventing gradual long-term cognitive decline as well, thus producing a validated database signal.…”

Section: Screening Of Individual Pharmacological Mechanisms For Corrementioning

confidence: 99%

“…On the other side, analgesics (0.45, 46 df), corticosteroids (0.34, 42 df), anti-acid (0.45, 16 df), anti-arrythmic (0.55, 13 df), antibiotics (0.5, 5 df), anti-cancer therapies (0.25, 29 df), statins (0.6, 13 df), antidepressants (0.45, 17 df), antifungals (0.4, 19 df), overall antihypertensives (0.9, 28 df), bronchodilators (0.6, 17 df) display the opposite trend of distributing in favour of the lower Z-score octiles. Thus, PDE5 inhibitors [42], antiplatelet [43,44], vasodilators [43,45], antimigraine [38,39], antivirals [46], probiotics [47], magnesium [48,49], transdermal oestrogen ( Table 2) and possibly metformin [40,41,50,51] are the agents of interest to perhaps combine with the multivitamin-multimineral formulas of Table 2. Conversely, the signals by corticosteroids [52,53], anti-cancer therapies [54,55], anti-acid drugs [56,57], infections underlying use of antibiotics and antifungals [58], the link between dementia and respiratory deficiency [59], between dementia and cardiac arrythmia [44] mostly align with outside evidence of involvement in neurodegeneration.…”

Section: Screening Of Individual Pharmacological Mechanisms For Corrementioning

confidence: 99%

Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy

Mayburd

Koivogui²,

Baranova

2019

PLoS ONE

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Preventive treatments for dementia are warranted. Here we show that utilization of certain combinations of prescription medications and supplements correlates with reduced rates of cognitive decline. More than 1,900 FDA-approved agents and supplements were collapsed into 53 mechanism-based groups and traced in electronic medical records (EMRs) for >50,000 patients. These mechanistic groups were aligned with the data presented in more than 300 clinical trials, then regression model was built to fit the signals from EMRs to clinical trial performance. While EMR signals of each single agents correlated with clinical performance relatively weakly, the signals produced by combinations of active compounds were highly correlated with the clinical trial performance (R = 0.93, p = 3.8 x10^-8). Higher ranking pharmacological modalities were traced in patient profiles as their combinations, producing protective complexity estimates reflecting degrees of exposure to beneficial polypharmacy. For each age strata, the higher was the protective complexity score, the lower was the prevalence of dementia, with maximized life-long effects for the highest regression score /diversity compositions. The connection was less strong in individuals already diagnosed with cognitive impairment. Confounder analysis confirmed an independent effect of protective complexity in multivariate context. A sub-cohort with lifelong odds of dementia decreased > 5-folds was identified; this sub-cohort should be studied in further details, including controlled clinical trials. In short, our study systematically explored combinatorial preventive treatment regimens for age-associated multi-morbidity, with an emphasis on neurodegeneration, and provided extensive evidence for their feasibility.Funding: AM is the Founder of Neurocombinatorix LLC, and MK is affiliated with the organization. Neurocombinatorix LLC does not conduct commercial activity and did not provide any funds for research. The authors volunteered to the effort without any salaries, no other parties have a role in the study design, data collection and analysis, Recent decreases in the rate of dementia and a shift to later ages of onset are encouraging [4]. However, in a first quartile of life expectancy, dementia still accounts for 1 in every 6 deaths, and is a major source of disability [1]. While multiple clinical trials for single dementia combating agents are ongoing [5], earlier stages of neurodegeneration process largely remain unexplored in humans.On the other hand, recent studies in model animals are encouraging. Particular successful efforts in visible rejuvenation of already differentiated tissues are reviewed in [6]). NAD+ supplementation has been associated with an extension of murine lifespan by 10-15% [7,8] through the mechanism likely related to overall brain function. The maintenance of microvasculature [9,10], the clearance of misfolded proteins [11], the neuroprotection [12,13], and the regulation of cholinesterase [13] were shown to be comparably important for the prevention...

show abstract

Decreased risk of dementia in migraine patients with traditional Chinese medicine use: a population-based cohort study

Cited by 18 publications

References 45 publications

Increased risk of neurodegenerative dementia in women with migraines

Increased risk of neurodegenerative dementia in women with migraines

Data-driven analysis of biomedical literature suggests broad-spectrum benefits of culinary herbs and spices

Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy

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