Decreased secretion of GLP-1 and GLP-2 after oral glucose in obese versus lean healthy human subjects

Dietary impact on fasting and stimulated GLP-1 secretion in different metabolic conditions – a narrative review

“…Basal- and food-dependent GLP-1 secretion has been hypothesized to differ between healthy adults and adults with IGT or T2DM; however, the results are conflicting. Some studies have shown reduced basal or postprandial GLP-1 concentrations in patients with obesity or T2DM [ [35] , [36] , [37] , [38] ]. Simon et al.…”

“…Simon et al. [ 37 ] found that the glucose-stimulated secretion of GLP-1 was lower in individuals with obesity than in their age- and sex-matched lean controls. Similar findings were reported in a large study involving 1400 individuals [ 39 ].…”